Vascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment.

Hdl Handle:
http://hdl.handle.net/10147/251857
Title:
Vascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment.
Authors:
Toomey, Desmond P; Manahan, Ellen; McKeown, Ciara; Rogers, Annamarie; McMillan, Helen; Geary, Michael; Conlon, Kevin C; Murphy, Joseph F
Affiliation:
Professorial Surgical Unit, University of Dublin, Trinity College, Dublin, Ireland.
Citation:
Vascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment. 2010, 39 (5):595-603 Pancreas
Publisher:
Pancreas
Journal:
Pancreas
Issue Date:
Jul-2010
URI:
http://hdl.handle.net/10147/251857
DOI:
10.1097/MPA.0b013e3181c6575d
PubMed ID:
20118820
Abstract:
Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in angiogenesis and VEGF regulation.
Item Type:
Article
Language:
en
MeSH:
Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelium, Vascular; Humans; Neovascularization, Pathologic; Pancreatic Neoplasms; Pyrazoles; Sulfonamides; Tumor Cells, Cultured; Vascular Endothelial Growth Factors
ISSN:
1536-4828

Full metadata record

DC FieldValue Language
dc.contributor.authorToomey, Desmond Pen_GB
dc.contributor.authorManahan, Ellenen_GB
dc.contributor.authorMcKeown, Ciaraen_GB
dc.contributor.authorRogers, Annamarieen_GB
dc.contributor.authorMcMillan, Helenen_GB
dc.contributor.authorGeary, Michaelen_GB
dc.contributor.authorConlon, Kevin Cen_GB
dc.contributor.authorMurphy, Joseph Fen_GB
dc.date.accessioned2012-11-12T16:26:04Z-
dc.date.available2012-11-12T16:26:04Z-
dc.date.issued2010-07-
dc.identifier.citationVascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment. 2010, 39 (5):595-603 Pancreasen_GB
dc.identifier.issn1536-4828-
dc.identifier.pmid20118820-
dc.identifier.doi10.1097/MPA.0b013e3181c6575d-
dc.identifier.urihttp://hdl.handle.net/10147/251857-
dc.description.abstractCyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in angiogenesis and VEGF regulation.en_GB
dc.language.isoenen
dc.publisherPancreasen_GB
dc.rightsArchived with thanks to Pancreasen_GB
dc.subject.meshAngiogenesis Inhibitors-
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal-
dc.subject.meshCell Survival-
dc.subject.meshCyclooxygenase 2-
dc.subject.meshCyclooxygenase 2 Inhibitors-
dc.subject.meshDinoprostone-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshHumans-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshPancreatic Neoplasms-
dc.subject.meshPyrazoles-
dc.subject.meshSulfonamides-
dc.subject.meshTumor Cells, Cultured-
dc.subject.meshVascular Endothelial Growth Factors-
dc.titleVascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment.en_GB
dc.typeArticleen
dc.contributor.departmentProfessorial Surgical Unit, University of Dublin, Trinity College, Dublin, Ireland.en_GB
dc.identifier.journalPancreasen_GB
dc.description.provinceLeinsteren

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