Fetal growth disorders in twin gestations.

2.50
Hdl Handle:
http://hdl.handle.net/10147/250595
Title:
Fetal growth disorders in twin gestations.
Authors:
Breathnach, Fionnuala M; Malone, Fergal D
Affiliation:
Department of Obstetrics and Gynecology, Royal College of Surgeons in Ireland, Rotunda Hospital, Dublin, Ireland. fbreathnach@rcsi.ie
Citation:
Fetal growth disorders in twin gestations. 2012, 36 (3):175-81 Semin. Perinatol.
Journal:
Seminars in perinatology
Issue Date:
Jun-2012
URI:
http://hdl.handle.net/10147/250595
DOI:
10.1053/j.semperi.2012.02.002
PubMed ID:
22713498
Abstract:
Twin growth is frequently mismatched. This review serves to explore the pathophysiologic mechanisms that underlie growth aberrations in twin gestations, the prenatal recognition of abnormal twin growth, and the critical importance of stratifying management of abnormal twin growth by chorionicity. Although poor in utero growth of both twins may reflect maternal factors resulting in global uteroplacental dysfunction, discordant twin growth may be attributed to differences in genetic potential between co-twins, placental dysfunction confined to one placenta only, or one placental territory within a shared placenta. In addition, twin-twin transfusion syndrome represents a distinct entity of which discordant growth is a common feature. Discordant growth is recognized as an independent risk factor for adverse perinatal outcome. Intertwin birth weight disparity of 18% or more should be considered to represent a discordance threshold, which serves as an independent risk factor for adverse perinatal outcome. At this cutoff, perinatal morbidity is found to increase both for the larger and the smaller twin within a discordant pair. There remains uncertainty surrounding the sonographic parameters that are most predictive of discordance. Although heightening of fetal surveillance in the face of discordant twin growth follows the principles applied to singleton gestations complicated by fetal growth restriction, the timing of intervention is largely influenced by chorionicity.
Item Type:
Article
Language:
en
MeSH:
Birth Weight; Female; Fetal Development; Fetal Diseases; Fetal Growth Retardation; Fetofetal Transfusion; Growth Disorders; Humans; Placental Insufficiency; Pregnancy; Pregnancy, Twin; Ultrasonography, Prenatal
ISSN:
1558-075X

Full metadata record

DC FieldValue Language
dc.contributor.authorBreathnach, Fionnuala Men_GB
dc.contributor.authorMalone, Fergal Den_GB
dc.date.accessioned2012-10-30T14:53:44Z-
dc.date.available2012-10-30T14:53:44Z-
dc.date.issued2012-06-
dc.identifier.citationFetal growth disorders in twin gestations. 2012, 36 (3):175-81 Semin. Perinatol.en_GB
dc.identifier.issn1558-075X-
dc.identifier.pmid22713498-
dc.identifier.doi10.1053/j.semperi.2012.02.002-
dc.identifier.urihttp://hdl.handle.net/10147/250595-
dc.description.abstractTwin growth is frequently mismatched. This review serves to explore the pathophysiologic mechanisms that underlie growth aberrations in twin gestations, the prenatal recognition of abnormal twin growth, and the critical importance of stratifying management of abnormal twin growth by chorionicity. Although poor in utero growth of both twins may reflect maternal factors resulting in global uteroplacental dysfunction, discordant twin growth may be attributed to differences in genetic potential between co-twins, placental dysfunction confined to one placenta only, or one placental territory within a shared placenta. In addition, twin-twin transfusion syndrome represents a distinct entity of which discordant growth is a common feature. Discordant growth is recognized as an independent risk factor for adverse perinatal outcome. Intertwin birth weight disparity of 18% or more should be considered to represent a discordance threshold, which serves as an independent risk factor for adverse perinatal outcome. At this cutoff, perinatal morbidity is found to increase both for the larger and the smaller twin within a discordant pair. There remains uncertainty surrounding the sonographic parameters that are most predictive of discordance. Although heightening of fetal surveillance in the face of discordant twin growth follows the principles applied to singleton gestations complicated by fetal growth restriction, the timing of intervention is largely influenced by chorionicity.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Seminars in perinatologyen_GB
dc.subject.meshBirth Weight-
dc.subject.meshFemale-
dc.subject.meshFetal Development-
dc.subject.meshFetal Diseases-
dc.subject.meshFetal Growth Retardation-
dc.subject.meshFetofetal Transfusion-
dc.subject.meshGrowth Disorders-
dc.subject.meshHumans-
dc.subject.meshPlacental Insufficiency-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy, Twin-
dc.subject.meshUltrasonography, Prenatal-
dc.titleFetal growth disorders in twin gestations.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Obstetrics and Gynecology, Royal College of Surgeons in Ireland, Rotunda Hospital, Dublin, Ireland. fbreathnach@rcsi.ieen_GB
dc.identifier.journalSeminars in perinatologyen_GB
dc.description.provinceLeinsteren
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