Developing core outcome sets for clinical trials: issues to consider

Hdl Handle:
http://hdl.handle.net/10147/248971
Title:
Developing core outcome sets for clinical trials: issues to consider
Authors:
Williamson, Paula R; Altman, Douglas G; Blazeby, Jane M; Clarke, Mike; Devane, Declan; Gargon, Elizabeth; Tugwell, Peter
Citation:
Trials. 2012 Aug 06;13(1):132
Issue Date:
6-Aug-2012
URI:
http://dx.doi.org/10.1186/1745-6215-13-132; http://hdl.handle.net/10147/248971
Abstract:
Abstract The selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to influence policy and practice then the chosen outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. There is a growing recognition that insufficient attention has been paid to the outcomes measured in clinical trials. These issues could be addressed through the development and use of an agreed standardized collection of outcomes, known as a core outcome set, which should be measured and reported, as a minimum, in all trials for a specific clinical area. Accumulating work in this area has identified the need for general guidance on the development of core outcome sets. Key issues to consider in the development of a core outcome set include its scope, the stakeholder groups to involve, choice of consensus method and the achievement of a consensus.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorWilliamson, Paula R-
dc.contributor.authorAltman, Douglas G-
dc.contributor.authorBlazeby, Jane M-
dc.contributor.authorClarke, Mike-
dc.contributor.authorDevane, Declan-
dc.contributor.authorGargon, Elizabeth-
dc.contributor.authorTugwell, Peter-
dc.date.accessioned2012-10-16T08:53:11Z-
dc.date.available2012-10-16T08:53:11Z-
dc.date.issued2012-08-06-
dc.identifier.citationTrials. 2012 Aug 06;13(1):132-
dc.identifier.urihttp://dx.doi.org/10.1186/1745-6215-13-132-
dc.identifier.urihttp://hdl.handle.net/10147/248971-
dc.description.abstractAbstract The selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to influence policy and practice then the chosen outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. There is a growing recognition that insufficient attention has been paid to the outcomes measured in clinical trials. These issues could be addressed through the development and use of an agreed standardized collection of outcomes, known as a core outcome set, which should be measured and reported, as a minimum, in all trials for a specific clinical area. Accumulating work in this area has identified the need for general guidance on the development of core outcome sets. Key issues to consider in the development of a core outcome set include its scope, the stakeholder groups to involve, choice of consensus method and the achievement of a consensus.-
dc.titleDeveloping core outcome sets for clinical trials: issues to consider-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderPaula R Williamson et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2012-10-15T15:07:52Z-
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