Prospective study of falls and risk factors for falls in adults with advanced cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10147/248580
Title:
Prospective study of falls and risk factors for falls in adults with advanced cancer.
Authors:
Stone, Carol A; Lawlor, Peter G; Savva, George M; Bennett, Kathleen; Kenny, Rose Anne
Affiliation:
Our Lady's Hospice and Care Services, Harold's Cross, Ireland. carolstone130@yahoo.co.uk
Citation:
Prospective study of falls and risk factors for falls in adults with advanced cancer. 2012, 30 (17):2128-33 J. Clin. Oncol.
Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Issue Date:
10-Jun-2012
URI:
http://hdl.handle.net/10147/248580
DOI:
10.1200/JCO.2011.40.7791
PubMed ID:
22585687
Abstract:
Retrospective studies of inpatients with cancer suggest that a cancer diagnosis confers a high risk of falls. In adults with advanced cancer, we aimed to prospectively document the incidence of falls, identify the risk factors, and determine if falls in this population occur predominantly in older patients.; Patients admitted consecutively to community and inpatient palliative care services with metastatic or locoregionally advanced cancer who were mobile without assistance were recruited. Risk-factor assessment was conducted on initial encounter. Patients underwent follow-up via weekly telephone contact for 6 months or until time of fall or death. Relationship between covariates and time to fall was examined using hazard ratios (HRs) derived from univariate and multivariate Cox proportional hazards models.; Of 185 participants (52.4% men; mean age 68 ± standard deviation of 12.6 years), 50.3% fell; 35 (53%) of 66 participants age < 65 years and 58 (48.7%) of 119 age ≥ 65 years fell; 61.3% of falls occurred in the community; 42% resulted in injury. Median time to fall was 96 days (95% CI, 64.66 to 127.34). Primary brain tumor or brain metastasis (HR 2.5; P = .002), number of falls in the preceding 3 months (HR, 1.27; P = .005), severity of depression (HR, 1.12; P = .012), benzodiazepine dose (HR, 1.05; P = .004), and cancer-related pain (HR, 1.96; P = .024) were independently associated with time to fall in multivariate analysis.; Fifty percent of adults with advanced cancer, regardless of age, will experience a fall associated with high risk of physical injury. There is a compelling need to assess the efficacy of assessment and management of modifiable fall risk factors in patients with advanced cancer.
Item Type:
Article
Language:
en
Description:
PURPOSE: Retrospective studies of inpatients with cancer suggest that a cancer diagnosis confers a high risk of falls. In adults with advanced cancer, we aimed to prospectively document the incidence of falls, identify the risk factors, and determine if falls in this population occur predominantly in older patients. PATIENTS AND METHODS: Patients admitted consecutively to community and inpatient palliative care services with metastatic or locoregionally advanced cancer who were mobile without assistance were recruited. Risk-factor assessment was conducted on initial encounter. Patients underwent follow-up via weekly telephone contact for 6 months or until time of fall or death. Relationship between covariates and time to fall was examined using hazard ratios (HRs) derived from univariate and multivariate Cox proportional hazards models. RESULTS: Of 185 participants (52.4% men; mean age 68 ± standard deviation of 12.6 years), 50.3% fell; 35 (53%) of 66 participants age < 65 years and 58 (48.7%) of 119 age ≥ 65 years fell; 61.3% of falls occurred in the community; 42% resulted in injury. Median time to fall was 96 days (95% CI, 64.66 to 127.34). Primary brain tumor or brain metastasis (HR 2.5; P = .002), number of falls in the preceding 3 months (HR, 1.27; P = .005), severity of depression (HR, 1.12; P = .012), benzodiazepine dose (HR, 1.05; P = .004), and cancer-related pain (HR, 1.96; P = .024) were independently associated with time to fall in multivariate analysis. CONCLUSION: Fifty percent of adults with advanced cancer, regardless of age, will experience a fall associated with high risk of physical injury. There is a compelling need to assess the efficacy of assessment and management of modifiable fall risk factors in patients with advanced cancer.
MeSH:
Accidental Falls; Aged; Aging; Female; Humans; Incidence; Male; Middle Aged; Neoplasms; Palliative Care; Proportional Hazards Models; Prospective Studies; Regression Analysis; Risk; Risk Factors; Time Factors
ISSN:
1527-7755

Full metadata record

DC FieldValue Language
dc.contributor.authorStone, Carol Aen_GB
dc.contributor.authorLawlor, Peter Gen_GB
dc.contributor.authorSavva, George Men_GB
dc.contributor.authorBennett, Kathleenen_GB
dc.contributor.authorKenny, Rose Anneen_GB
dc.date.accessioned2012-10-12T14:47:57Z-
dc.date.available2012-10-12T14:47:57Z-
dc.date.issued2012-06-10-
dc.identifier.citationProspective study of falls and risk factors for falls in adults with advanced cancer. 2012, 30 (17):2128-33 J. Clin. Oncol.en_GB
dc.identifier.issn1527-7755-
dc.identifier.pmid22585687-
dc.identifier.doi10.1200/JCO.2011.40.7791-
dc.identifier.urihttp://hdl.handle.net/10147/248580-
dc.descriptionPURPOSE: Retrospective studies of inpatients with cancer suggest that a cancer diagnosis confers a high risk of falls. In adults with advanced cancer, we aimed to prospectively document the incidence of falls, identify the risk factors, and determine if falls in this population occur predominantly in older patients. PATIENTS AND METHODS: Patients admitted consecutively to community and inpatient palliative care services with metastatic or locoregionally advanced cancer who were mobile without assistance were recruited. Risk-factor assessment was conducted on initial encounter. Patients underwent follow-up via weekly telephone contact for 6 months or until time of fall or death. Relationship between covariates and time to fall was examined using hazard ratios (HRs) derived from univariate and multivariate Cox proportional hazards models. RESULTS: Of 185 participants (52.4% men; mean age 68 ± standard deviation of 12.6 years), 50.3% fell; 35 (53%) of 66 participants age < 65 years and 58 (48.7%) of 119 age ≥ 65 years fell; 61.3% of falls occurred in the community; 42% resulted in injury. Median time to fall was 96 days (95% CI, 64.66 to 127.34). Primary brain tumor or brain metastasis (HR 2.5; P = .002), number of falls in the preceding 3 months (HR, 1.27; P = .005), severity of depression (HR, 1.12; P = .012), benzodiazepine dose (HR, 1.05; P = .004), and cancer-related pain (HR, 1.96; P = .024) were independently associated with time to fall in multivariate analysis. CONCLUSION: Fifty percent of adults with advanced cancer, regardless of age, will experience a fall associated with high risk of physical injury. There is a compelling need to assess the efficacy of assessment and management of modifiable fall risk factors in patients with advanced cancer.en_GB
dc.description.abstractRetrospective studies of inpatients with cancer suggest that a cancer diagnosis confers a high risk of falls. In adults with advanced cancer, we aimed to prospectively document the incidence of falls, identify the risk factors, and determine if falls in this population occur predominantly in older patients.-
dc.description.abstractPatients admitted consecutively to community and inpatient palliative care services with metastatic or locoregionally advanced cancer who were mobile without assistance were recruited. Risk-factor assessment was conducted on initial encounter. Patients underwent follow-up via weekly telephone contact for 6 months or until time of fall or death. Relationship between covariates and time to fall was examined using hazard ratios (HRs) derived from univariate and multivariate Cox proportional hazards models.-
dc.description.abstractOf 185 participants (52.4% men; mean age 68 ± standard deviation of 12.6 years), 50.3% fell; 35 (53%) of 66 participants age < 65 years and 58 (48.7%) of 119 age ≥ 65 years fell; 61.3% of falls occurred in the community; 42% resulted in injury. Median time to fall was 96 days (95% CI, 64.66 to 127.34). Primary brain tumor or brain metastasis (HR 2.5; P = .002), number of falls in the preceding 3 months (HR, 1.27; P = .005), severity of depression (HR, 1.12; P = .012), benzodiazepine dose (HR, 1.05; P = .004), and cancer-related pain (HR, 1.96; P = .024) were independently associated with time to fall in multivariate analysis.-
dc.description.abstractFifty percent of adults with advanced cancer, regardless of age, will experience a fall associated with high risk of physical injury. There is a compelling need to assess the efficacy of assessment and management of modifiable fall risk factors in patients with advanced cancer.-
dc.language.isoenen
dc.rightsArchived with thanks to Journal of clinical oncology : official journal of the American Society of Clinical Oncologyen_GB
dc.subject.meshAccidental Falls-
dc.subject.meshAged-
dc.subject.meshAging-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms-
dc.subject.meshPalliative Care-
dc.subject.meshProportional Hazards Models-
dc.subject.meshProspective Studies-
dc.subject.meshRegression Analysis-
dc.subject.meshRisk-
dc.subject.meshRisk Factors-
dc.subject.meshTime Factors-
dc.titleProspective study of falls and risk factors for falls in adults with advanced cancer.en_GB
dc.typeArticleen
dc.contributor.departmentOur Lady's Hospice and Care Services, Harold's Cross, Ireland. carolstone130@yahoo.co.uken_GB
dc.identifier.journalJournal of clinical oncology : official journal of the American Society of Clinical Oncologyen_GB

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