Reports of side effects associated with the use of drugs 1984

Hdl Handle:
http://hdl.handle.net/10147/244333
Title:
Reports of side effects associated with the use of drugs 1984
Authors:
National Drugs Advisory Board (NDAB)
Publisher:
National Drugs Advisory Board (NDAB)
Issue Date:
1984
URI:
http://hdl.handle.net/10147/244333
Item Type:
Report
Language:
en
Description:
During 1984 the National Drugs Advisory Board received 803 reports, from which 1668 side-effects were recorded. Of these, the largest percentages were as follows: Drugs Affecting the Central Nervous System 50% (including Non-Steroidal Anti-lnfammatory Drugs 17% Anti-Histamines 50% Anti-Infective Drugs 17% Cardiovascular Drugs 17% 1. Benzodiazepines were associated with reports of behavioural disorders and cerebral irritability, including hallucinations and aggression. Dependence and withdrawal syndromes occurred in a few cases. These side-effects occurred in young adults as well as in the elderly patients. This underlines the importance of introducing benzodiazepine treatment cautiously and limiting its duration to short term courses. 2. A report was received of ventricular fibrillation following use of a depot preparation of fluphenazine. In view of the widespread use of the major tranquillisers in this form it is Important to be aware of the possibility of cardiac involvement particularly if cardiovascular treatment is being given as well. 3. An unusual reaction was associated with nomifensine; namely, acute tubular necrosis and haemolytic anaemia. The patient recovered. · 4. A report of hypomania associated with the use of phentermine is a further reminder of the need for care in selecting patients for whom treatment with anorectics is appropriate. 5. A number of reports of intestinal mucosal damage and colitis were reported with non-steroidal anti-inflammatory agents. These emphasise the need wherever possible to avoid the use of these drugs not only in patients with peptic ulcer disease but in those with intestinal disorders. 6. Bizarre behaviour and respiratory depression have occurred in a number of young children receiving antihistamines and sympathomimetics as treatment for the symptoms of coughs and head colds. These agents should be avoided in children under 2 years of age and used sparingly in older children. 7. Five cases of hepatitis occurred after long term methyldopa treatment and in addition there were three cases of abnormal liver function which appeared within the first few months of treatment. The latter three cases recovered after discontinuing treatment with methyldopa. Regular monitoring of liver function is essential in patients who are receiving long term treatment with methyldpoa, to ensure early detection of liver function disorder before it is irreversible. 8. Co-trimoxazole was associated with 63 side-effects, including two cases of renal dysfunction and two cases of Stevens Johnson Syndrome. The use of Co-trimoxazole is widespread in all age groups and recovery from side effects is usually rapid after treatment is stopped. However, effects on the kidney and bone marrow may be very severe and recovery slow and incomplete.
Keywords:
MEDICINES; CAUSES OF HARM
Local subject classification:
ADVERSE EVENTS

Full metadata record

DC FieldValue Language
dc.contributor.authorNational Drugs Advisory Board (NDAB)en_GB
dc.date.accessioned2012-09-17T14:40:27Z-
dc.date.available2012-09-17T14:40:27Z-
dc.date.issued1984-
dc.identifier.urihttp://hdl.handle.net/10147/244333-
dc.descriptionDuring 1984 the National Drugs Advisory Board received 803 reports, from which 1668 side-effects were recorded. Of these, the largest percentages were as follows: Drugs Affecting the Central Nervous System 50% (including Non-Steroidal Anti-lnfammatory Drugs 17% Anti-Histamines 50% Anti-Infective Drugs 17% Cardiovascular Drugs 17% 1. Benzodiazepines were associated with reports of behavioural disorders and cerebral irritability, including hallucinations and aggression. Dependence and withdrawal syndromes occurred in a few cases. These side-effects occurred in young adults as well as in the elderly patients. This underlines the importance of introducing benzodiazepine treatment cautiously and limiting its duration to short term courses. 2. A report was received of ventricular fibrillation following use of a depot preparation of fluphenazine. In view of the widespread use of the major tranquillisers in this form it is Important to be aware of the possibility of cardiac involvement particularly if cardiovascular treatment is being given as well. 3. An unusual reaction was associated with nomifensine; namely, acute tubular necrosis and haemolytic anaemia. The patient recovered. · 4. A report of hypomania associated with the use of phentermine is a further reminder of the need for care in selecting patients for whom treatment with anorectics is appropriate. 5. A number of reports of intestinal mucosal damage and colitis were reported with non-steroidal anti-inflammatory agents. These emphasise the need wherever possible to avoid the use of these drugs not only in patients with peptic ulcer disease but in those with intestinal disorders. 6. Bizarre behaviour and respiratory depression have occurred in a number of young children receiving antihistamines and sympathomimetics as treatment for the symptoms of coughs and head colds. These agents should be avoided in children under 2 years of age and used sparingly in older children. 7. Five cases of hepatitis occurred after long term methyldopa treatment and in addition there were three cases of abnormal liver function which appeared within the first few months of treatment. The latter three cases recovered after discontinuing treatment with methyldopa. Regular monitoring of liver function is essential in patients who are receiving long term treatment with methyldpoa, to ensure early detection of liver function disorder before it is irreversible. 8. Co-trimoxazole was associated with 63 side-effects, including two cases of renal dysfunction and two cases of Stevens Johnson Syndrome. The use of Co-trimoxazole is widespread in all age groups and recovery from side effects is usually rapid after treatment is stopped. However, effects on the kidney and bone marrow may be very severe and recovery slow and incomplete.en_GB
dc.language.isoenen
dc.publisherNational Drugs Advisory Board (NDAB)en_GB
dc.subjectMEDICINESen_GB
dc.subjectCAUSES OF HARMen_GB
dc.subject.otherADVERSE EVENTSen_GB
dc.titleReports of side effects associated with the use of drugs 1984en_GB
dc.typeReporten
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