2.50
Hdl Handle:
http://hdl.handle.net/10147/244242
Title:
Report of side effects associated with the use of drugs 1981
Authors:
National Drugs Advisory Board (NDAB)
Publisher:
National Drugs Advisory Board (NDAB)
Issue Date:
1981
URI:
http://hdl.handle.net/10147/244242
Item Type:
Report
Language:
en
Description:
The National Drugs Advisory Board received 662 reports during 1981 from which 1264 side-effects were recorded. Of these 33.3% concerned drugs affecting the central nervous system and 27% involved anti-infective drugs. Of the drugs affecting the central nervous system, over half belonged to t he peripherally acting analgesics. There were 11 reports of interactions between drugs. Two reports involved aminophylline, one resulting in death; this probably reflects the increasing use of the xanthines. There were 4 instances in which Cimetidine used prophylactically during renal transplant procedures was associated with rejection. It is possible that the Cimetidine reduced the activity of hepatic microsomal enzymes thus interfering with the metabolism of concurrently administered Prednisone. Particular attention should be drawn to the respiratory depression reported following the concurrent use of diazepam with buprenorphine. There were 10 deaths recorded in association with the use of these drugs. In at least 2 cases relative over dosage was probably responsible for the deaths. One death is reported as occurring in a baby whose mother was receiving an anti-nauseant during pregnancy. In view of the absence of an appropriate time relationship the drug is not regarded as a likely causative agent. Another death was reported in association with the use of an intravenous x-ray contrast medium. This underlines the need for such investigations to be conducted only where appropriate resuscitation facilities are immediately available. Particular attention should be drawn to some of the reports :- Following the use of atropine eyedrops sufficient absorption occurred to produce evidence of atropine poisoning. Use of timolol eyedrops were shown to result in sufficient absorption to aggravate symptoms of myasthenia. Most of the beta-blockers have now been associated with reports of eye effects including dryness, blepharitis and soreness. It would still appear wise to consider discontinuing the beta-b!ocker if such features develop in the patient. Although 19 side-effects are reported with Mexiletine, these occurred in only 4 patients of 3000 patients treated. The 20 side-effects reported with Nifedipine occurred in 13 patients of approximately 1700 patients who received the drug. There were 34 side-effects reported as occurring in 21 patients who were given Metoclopramide. Most of these were extrapyramidal effects. The side-effects reported with Trimethoprim totalled 26 occurring in 12 patients. They were similar in type to those already reported with Trimethoprim with Sulpharnethoxazole.
Keywords:
MEDICINES; ADVERSE EVENTS

Full metadata record

DC FieldValue Language
dc.contributor.authorNational Drugs Advisory Board (NDAB)en_GB
dc.date.accessioned2012-09-17T09:47:34Z-
dc.date.available2012-09-17T09:47:34Z-
dc.date.issued1981-
dc.identifier.urihttp://hdl.handle.net/10147/244242-
dc.descriptionThe National Drugs Advisory Board received 662 reports during 1981 from which 1264 side-effects were recorded. Of these 33.3% concerned drugs affecting the central nervous system and 27% involved anti-infective drugs. Of the drugs affecting the central nervous system, over half belonged to t he peripherally acting analgesics. There were 11 reports of interactions between drugs. Two reports involved aminophylline, one resulting in death; this probably reflects the increasing use of the xanthines. There were 4 instances in which Cimetidine used prophylactically during renal transplant procedures was associated with rejection. It is possible that the Cimetidine reduced the activity of hepatic microsomal enzymes thus interfering with the metabolism of concurrently administered Prednisone. Particular attention should be drawn to the respiratory depression reported following the concurrent use of diazepam with buprenorphine. There were 10 deaths recorded in association with the use of these drugs. In at least 2 cases relative over dosage was probably responsible for the deaths. One death is reported as occurring in a baby whose mother was receiving an anti-nauseant during pregnancy. In view of the absence of an appropriate time relationship the drug is not regarded as a likely causative agent. Another death was reported in association with the use of an intravenous x-ray contrast medium. This underlines the need for such investigations to be conducted only where appropriate resuscitation facilities are immediately available. Particular attention should be drawn to some of the reports :- Following the use of atropine eyedrops sufficient absorption occurred to produce evidence of atropine poisoning. Use of timolol eyedrops were shown to result in sufficient absorption to aggravate symptoms of myasthenia. Most of the beta-blockers have now been associated with reports of eye effects including dryness, blepharitis and soreness. It would still appear wise to consider discontinuing the beta-b!ocker if such features develop in the patient. Although 19 side-effects are reported with Mexiletine, these occurred in only 4 patients of 3000 patients treated. The 20 side-effects reported with Nifedipine occurred in 13 patients of approximately 1700 patients who received the drug. There were 34 side-effects reported as occurring in 21 patients who were given Metoclopramide. Most of these were extrapyramidal effects. The side-effects reported with Trimethoprim totalled 26 occurring in 12 patients. They were similar in type to those already reported with Trimethoprim with Sulpharnethoxazole.en_GB
dc.language.isoenen
dc.publisherNational Drugs Advisory Board (NDAB)en_GB
dc.subjectMEDICINESen_GB
dc.subjectADVERSE EVENTSen_GB
dc.titleReport of side effects associated with the use of drugs 1981en_GB
dc.typeReporten
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