Hdl Handle:
http://hdl.handle.net/10147/244214
Title:
Reports of side effects associated with the use of drugs 1977
Authors:
National Drugs Advisory Board (NDAB)
Publisher:
National Drugs Advisory Board (NDAB)
Issue Date:
1977
URI:
http://hdl.handle.net/10147/244214
Item Type:
Report
Language:
en
Description:
The National Drugs Advisory Board received 525 Reports in all during 1977. From these 879 Side-Effects were recorded with the use of drugs during the year. There were 18 cases of Drug Interactions- these are listed separately. Four of these were Interactions of Alcohol with other central nervous system depressants. One Interaction of Alcohol with Propranolol produced hypoglycaemia . In view of the capacity of Propranolol to mask symptoms of hypoglycaemia it is particularly important in patients on Propranolol to beware of the use of Alcohol which may induce hypoglycaemia. Another Interaction of Propranolol with Methyldopa produced circulatory collapse in a patient. In one patient an Interaction of Pentobarbitone with Ethinyloestradiol and Norgestre1 resulted in withdrawal bleeding and subsequent pregnancy, possibly by the capacity of barbiturate to increase the rate of metabolism of the hormones, hence reducing their activity. Hysteria was induced by the use of Diazepam with Amitriptyline and acute delirium occurred when Disulfiram was used with Metoprolol. Both Perphenazine and Metoclopramide singly have a potential for inducing dystonic reactions and the combination gave an additive interaction.
Keywords:
MEDICINES; ADVERSE EVENTS

Full metadata record

DC FieldValue Language
dc.contributor.authorNational Drugs Advisory Board (NDAB)en_GB
dc.date.accessioned2012-09-17T08:40:30Z-
dc.date.available2012-09-17T08:40:30Z-
dc.date.issued1977-
dc.identifier.urihttp://hdl.handle.net/10147/244214-
dc.descriptionThe National Drugs Advisory Board received 525 Reports in all during 1977. From these 879 Side-Effects were recorded with the use of drugs during the year. There were 18 cases of Drug Interactions- these are listed separately. Four of these were Interactions of Alcohol with other central nervous system depressants. One Interaction of Alcohol with Propranolol produced hypoglycaemia . In view of the capacity of Propranolol to mask symptoms of hypoglycaemia it is particularly important in patients on Propranolol to beware of the use of Alcohol which may induce hypoglycaemia. Another Interaction of Propranolol with Methyldopa produced circulatory collapse in a patient. In one patient an Interaction of Pentobarbitone with Ethinyloestradiol and Norgestre1 resulted in withdrawal bleeding and subsequent pregnancy, possibly by the capacity of barbiturate to increase the rate of metabolism of the hormones, hence reducing their activity. Hysteria was induced by the use of Diazepam with Amitriptyline and acute delirium occurred when Disulfiram was used with Metoprolol. Both Perphenazine and Metoclopramide singly have a potential for inducing dystonic reactions and the combination gave an additive interaction.en_GB
dc.language.isoenen
dc.publisherNational Drugs Advisory Board (NDAB)en_GB
dc.subjectMEDICINESen_GB
dc.subjectADVERSE EVENTSen_GB
dc.titleReports of side effects associated with the use of drugs 1977en_GB
dc.typeReporten
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