Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.

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Irish Health Repository > Hospital Research > Leinster > St. Vincent's University Hospital > Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.

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Title:	Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.
Authors:	Kevans, David Gorman, Sheeona Tosetto, Miriam Sheahan, Kieran O'Donoghue, Diarmuid Mulcahy, Hugh O'Sullivan, Jacintha
Affiliation:	Centre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Citation:	Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer. 2012, 43 (2):305-13 J Gastrointest Cancer
Journal:	Journal of gastrointestinal cancer
Issue Date:	Jun-2012
URI:	http://hdl.handle.net/10147/244020
DOI:	10.1007/s12029-011-9277-x
PubMed ID:	21487682
Abstract:	In vitro studies have shown that clusterin modulates treatment sensitivity in a number of human cancers; however, the interaction between clusterin expression and hypoxia in controlling treatment response in CRC has not previously been examined. The aim of this study was to assess the effect of clusterin overexpression in CRC cells on sensitivity to 5-fluorouracil (5-FU), oxaliplatin and FOLFOX treatment under normoxic and graded hypoxic conditions.
Type:	Article
Language:	en
MeSH:	Antineoplastic Agents Apoptosis Blotting, Western Cell Hypoxia Cell Line, Tumor Cell Proliferation Clusterin Colorectal Neoplasms Drug Resistance, Neoplasm Enzyme-Linked Immunosorbent Assay Flow Cytometry Humans Transfection
ISSN:	1941-6636
Appears in Collections:	St. Vincent's University Hospital

Please use this identifier to cite or link to this item: http://hdl.handle.net/10147/244020
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