Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10147/244020
Title:
Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.
Authors:
Kevans, David; Gorman, Sheeona; Tosetto, Miriam; Sheahan, Kieran; O'Donoghue, Diarmuid; Mulcahy, Hugh; O'Sullivan, Jacintha
Affiliation:
Centre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Citation:
Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer. 2012, 43 (2):305-13 J Gastrointest Cancer
Journal:
Journal of gastrointestinal cancer
Issue Date:
Jun-2012
URI:
http://hdl.handle.net/10147/244020
DOI:
10.1007/s12029-011-9277-x
PubMed ID:
21487682
Abstract:
In vitro studies have shown that clusterin modulates treatment sensitivity in a number of human cancers; however, the interaction between clusterin expression and hypoxia in controlling treatment response in CRC has not previously been examined. The aim of this study was to assess the effect of clusterin overexpression in CRC cells on sensitivity to 5-fluorouracil (5-FU), oxaliplatin and FOLFOX treatment under normoxic and graded hypoxic conditions.
Item Type:
Article
Language:
en
MeSH:
Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Clusterin; Colorectal Neoplasms; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Transfection
ISSN:
1941-6636

Full metadata record

DC FieldValue Language
dc.contributor.authorKevans, Daviden_GB
dc.contributor.authorGorman, Sheeonaen_GB
dc.contributor.authorTosetto, Miriamen_GB
dc.contributor.authorSheahan, Kieranen_GB
dc.contributor.authorO'Donoghue, Diarmuiden_GB
dc.contributor.authorMulcahy, Hughen_GB
dc.contributor.authorO'Sullivan, Jacinthaen_GB
dc.date.accessioned2012-09-14T15:48:52Z-
dc.date.available2012-09-14T15:48:52Z-
dc.date.issued2012-06-
dc.identifier.citationClusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer. 2012, 43 (2):305-13 J Gastrointest Canceren_GB
dc.identifier.issn1941-6636-
dc.identifier.pmid21487682-
dc.identifier.doi10.1007/s12029-011-9277-x-
dc.identifier.urihttp://hdl.handle.net/10147/244020-
dc.description.abstractIn vitro studies have shown that clusterin modulates treatment sensitivity in a number of human cancers; however, the interaction between clusterin expression and hypoxia in controlling treatment response in CRC has not previously been examined. The aim of this study was to assess the effect of clusterin overexpression in CRC cells on sensitivity to 5-fluorouracil (5-FU), oxaliplatin and FOLFOX treatment under normoxic and graded hypoxic conditions.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Journal of gastrointestinal canceren_GB
dc.subject.meshAntineoplastic Agents-
dc.subject.meshApoptosis-
dc.subject.meshBlotting, Western-
dc.subject.meshCell Hypoxia-
dc.subject.meshCell Line, Tumor-
dc.subject.meshCell Proliferation-
dc.subject.meshClusterin-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshDrug Resistance, Neoplasm-
dc.subject.meshEnzyme-Linked Immunosorbent Assay-
dc.subject.meshFlow Cytometry-
dc.subject.meshHumans-
dc.subject.meshTransfection-
dc.titleClusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.en_GB
dc.typeArticleen
dc.contributor.departmentCentre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.en_GB
dc.identifier.journalJournal of gastrointestinal canceren_GB
dc.description.provinceLeinsteren

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