An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management.

Hdl Handle:
http://hdl.handle.net/10147/243773
Title:
An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management.
Authors:
Rock, Kathy; Rangaswamy, Guhan; O'Sullivan, Siobhra; Coffey, Jerome
Affiliation:
Department of Radiation Oncology, St. Luke's Hospital, Rathgar, Dublin 6, Ireland.
Citation:
An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management. 2011, 6 (5):391-393notBreast Care (Basel)
Publisher:
Karger
Journal:
Breast care (Basel, Switzerland)
Issue Date:
Oct-2011
URI:
http://hdl.handle.net/10147/243773
DOI:
10.1159/000333128
PubMed ID:
22619650
Abstract:
BACKGROUND: Primary lymphoma of the breast accounts for 0.04-0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%. CASE REPORT: We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin's lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no 'B' symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy. CONCLUSION: Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.
ISSN:
1661-3805

Full metadata record

DC FieldValue Language
dc.contributor.authorRock, Kathyen_GB
dc.contributor.authorRangaswamy, Guhanen_GB
dc.contributor.authorO'Sullivan, Siobhraen_GB
dc.contributor.authorCoffey, Jeromeen_GB
dc.date.accessioned2012-09-13T08:34:17Z-
dc.date.available2012-09-13T08:34:17Z-
dc.date.issued2011-10-
dc.identifier.citationAn Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management. 2011, 6 (5):391-393notBreast Care (Basel)en_GB
dc.identifier.issn1661-3805-
dc.identifier.pmid22619650-
dc.identifier.doi10.1159/000333128-
dc.identifier.urihttp://hdl.handle.net/10147/243773-
dc.description.abstractBACKGROUND: Primary lymphoma of the breast accounts for 0.04-0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%. CASE REPORT: We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin's lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no 'B' symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy. CONCLUSION: Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.en_GB
dc.languageENG-
dc.publisherKargeren_GB
dc.rightsArchived with thanks to Breast care (Basel, Switzerland)en_GB
dc.titleAn Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management.en_GB
dc.contributor.departmentDepartment of Radiation Oncology, St. Luke's Hospital, Rathgar, Dublin 6, Ireland.en_GB
dc.identifier.journalBreast care (Basel, Switzerland)en_GB
dc.description.provinceLeinsteren

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