In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer.

Hdl Handle:
http://hdl.handle.net/10147/243634
Title:
In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer.
Authors:
Murphy, Therese M; Sullivan, Linda; Lane, Caroline; O'Connor, Lisa; Barrett, Ciara; Hollywood, Donal; Lynch, Thomas; Lawler, Mark; Perry, Antoinette S
Affiliation:
Prostate Molecular Oncology, Institute of Molecular Medicine, Trinity College, Dublin, Ireland. murphyth@tcd.ie
Citation:
In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer. 2011, 71 (1):1-17 Prostate
Publisher:
Wiley
Journal:
The Prostate
Issue Date:
1-Jan-2011
URI:
http://hdl.handle.net/10147/243634
DOI:
10.1002/pros.21212
PubMed ID:
20564325
Abstract:
Aberrant DNA methylation has been implicated as a key survival mechanism in cancer, whereby promoter hypermethylation silences genes essential for many cellular processes including apoptosis. Limited data is available on the methylation profile of apoptotic genes in prostate cancer (CaP). The aim of this study was to profile methylation of apoptotic-related genes in CaP using denaturing high performance liquid chromatography (DHPLC).
Item Type:
Other
Language:
en
Keywords:
Apoptosis/genetics; DNA Methylation; Gene Targeting; Prostatic Neoplasms/genetics
MeSH:
Adenovirus Infections, Human; Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cohort Studies; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Targeting; Genetic Loci; Humans; Male; Middle Aged; Neoplasm Staging; Nucleic Acid Denaturation; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms
ISSN:
1097-0045

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, Therese Men_GB
dc.contributor.authorSullivan, Lindaen_GB
dc.contributor.authorLane, Carolineen_GB
dc.contributor.authorO'Connor, Lisaen_GB
dc.contributor.authorBarrett, Ciaraen_GB
dc.contributor.authorHollywood, Donalen_GB
dc.contributor.authorLynch, Thomasen_GB
dc.contributor.authorLawler, Marken_GB
dc.contributor.authorPerry, Antoinette Sen_GB
dc.date.accessioned2012-09-12T15:02:54Z-
dc.date.available2012-09-12T15:02:54Z-
dc.date.issued2011-01-01-
dc.identifier.citationIn silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer. 2011, 71 (1):1-17 Prostateen_GB
dc.identifier.issn1097-0045-
dc.identifier.pmid20564325-
dc.identifier.doi10.1002/pros.21212-
dc.identifier.urihttp://hdl.handle.net/10147/243634-
dc.description.abstractAberrant DNA methylation has been implicated as a key survival mechanism in cancer, whereby promoter hypermethylation silences genes essential for many cellular processes including apoptosis. Limited data is available on the methylation profile of apoptotic genes in prostate cancer (CaP). The aim of this study was to profile methylation of apoptotic-related genes in CaP using denaturing high performance liquid chromatography (DHPLC).en_GB
dc.language.isoenen
dc.publisherWileyen_GB
dc.rightsArchived with thanks to The Prostateen_GB
dc.subjectApoptosis/geneticsen_GB
dc.subjectDNA Methylationen_GB
dc.subjectGene Targetingen_GB
dc.subjectProstatic Neoplasms/geneticsen_GB
dc.subject.meshAdenovirus Infections, Human-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshApoptosis-
dc.subject.meshCell Line, Tumor-
dc.subject.meshChromatography, High Pressure Liquid-
dc.subject.meshCohort Studies-
dc.subject.meshDNA Methylation-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshGene Targeting-
dc.subject.meshGenetic Loci-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Staging-
dc.subject.meshNucleic Acid Denaturation-
dc.subject.meshPromoter Regions, Genetic-
dc.subject.meshProstatic Hyperplasia-
dc.subject.meshProstatic Intraepithelial Neoplasia-
dc.subject.meshProstatic Neoplasms-
dc.titleIn silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer.en_GB
dc.typeOtheren
dc.contributor.departmentProstate Molecular Oncology, Institute of Molecular Medicine, Trinity College, Dublin, Ireland. murphyth@tcd.ieen_GB
dc.identifier.journalThe Prostateen_GB
dc.description.provinceLeinsteren

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