Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011).

Hdl Handle:
http://hdl.handle.net/10147/241761
Title:
Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011).
Authors:
Bisceglia, Michele; Galliani, Carlos; Giannatempo, Giuseppe; Lauriola, Walter; Bianco, Mario; D'angelo, Vincenzo; Pizzolitto, Stefano; Vita, Giulia; Pasquinelli, Gianandrea; Magro, Gaetano; Dor, David Ben
Affiliation:
Departments of Pathology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo (FG), Italy. bismi@libero.it
Citation:
Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011). 2011, 18 (5):356-92 Adv Anat Pathol
Journal:
Advances in anatomic pathology
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10147/241761
DOI:
10.1097/PAP.0b013e318229c004
PubMed ID:
21841406
Abstract:
We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.
Item Type:
Article In Press
Language:
en
MeSH:
Brain Neoplasms; Cell Proliferation; Female; Humans; Male; Neoplasm Recurrence, Local; Radiotherapy, Adjuvant; Solitary Fibrous Tumors; Spinal Cord Neoplasms; Tumor Markers, Biological
ISSN:
1533-4031

Full metadata record

DC FieldValue Language
dc.contributor.authorBisceglia, Micheleen_GB
dc.contributor.authorGalliani, Carlosen_GB
dc.contributor.authorGiannatempo, Giuseppeen_GB
dc.contributor.authorLauriola, Walteren_GB
dc.contributor.authorBianco, Marioen_GB
dc.contributor.authorD'angelo, Vincenzoen_GB
dc.contributor.authorPizzolitto, Stefanoen_GB
dc.contributor.authorVita, Giuliaen_GB
dc.contributor.authorPasquinelli, Gianandreaen_GB
dc.contributor.authorMagro, Gaetanoen_GB
dc.contributor.authorDor, David Benen_GB
dc.date.accessioned2012-09-07T10:19:12Z-
dc.date.available2012-09-07T10:19:12Z-
dc.date.issued2011-09-
dc.identifier.citationSolitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011). 2011, 18 (5):356-92 Adv Anat Patholen_GB
dc.identifier.issn1533-4031-
dc.identifier.pmid21841406-
dc.identifier.doi10.1097/PAP.0b013e318229c004-
dc.identifier.urihttp://hdl.handle.net/10147/241761-
dc.description.abstractWe reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Advances in anatomic pathologyen_GB
dc.subject.meshBrain Neoplasms-
dc.subject.meshCell Proliferation-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshSolitary Fibrous Tumors-
dc.subject.meshSpinal Cord Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titleSolitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011).en_GB
dc.typeArticle In Pressen
dc.contributor.departmentDepartments of Pathology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo (FG), Italy. bismi@libero.iten_GB
dc.identifier.journalAdvances in anatomic pathologyen_GB
dc.description.provinceLeinsteren

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