Low-dose hydrocortisone (HC) replacement therapy is associated with improved bone remodeling balance in hypopituitary subjects

Hdl Handle:
http://hdl.handle.net/10147/240292
Title:
Low-dose hydrocortisone (HC) replacement therapy is associated with improved bone remodeling balance in hypopituitary subjects
Authors:
Behan, L A; Kelleher, G; Hannon, M J; Brady, J J; Rogers, B; Tormey, W; Smith, D; Thompson, C J; McKenna, M J; Agha, A
Citation:
Endocrine Reviews (2011) 32:3 Meeting Abstracts. : June 2011
Journal:
Endocrine Reviews
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10147/240292
Additional Links:
http://edrv.endojournals.org/cgi/content/meeting_abstract/32/03_MeetingAbstracts/P2-411?sid=37055afe-3553-4704-b98c-a11f11a2777b
Abstract:
The effect of commonly used glucocorticoid replacement regimens on bone health in hypopituitary subjects is not well known. We aimed to assess the effect of 3 hydrocortisone (HC) replacement dose regimens on bone turnover in this group.10 hypopituitary men with severe ACTH deficiency were randomised in a crossover design to 3 HC dose regimens, Dose A (20mg mane, 10mg tarde), Dose B (10mg twice daily) and Dose C (10mg mane, 5mg tarde). Following 6 weeks of each regimen participants underwent fasting sampling of bone turnover markers.Data from matched controls were used to produce a Z score for subject bone formation and resorption markers and to calculate the bone remodeling balance (formation Z score-resorption Z score) and turnover index ((formation Z + resorption Z)/2). A positive bone remodeling balance with increased turnover is consistent with a favourable bone cycle. Data are expressed as median (range).The Pro Collagen Type 1 Peptide (PINP) bone formation Z-score was significantly increased in Dose C, (1.805 (-0.6-10.24)) compared to Dose A (0.035 (-1.0-8.1)) p<0.05 while there was no difference in the C-terminal crosslinking telopeptide (CTx) resorption Z score. The bone remodeling balance was significantly lower for dose A -0.02 (-1.05-4.12) compared to dose C 1.13 (0.13-6.4) (p<0.05). Although there was a trend to an increased bone turnover index with the lower dose regimen, this was not statistically significant.Low dose HC replacement (10mg mane/5 mg tarde) was associated with increased bone formation and improved bone remodeling balance which is associated with a more favourable bone cycle. This may have a long term beneficial effect on bone health.
Item Type:
Conference Presentation
Language:
en

Full metadata record

DC FieldValue Language
dc.contributor.authorBehan, L Aen_GB
dc.contributor.authorKelleher, Gen_GB
dc.contributor.authorHannon, M Jen_GB
dc.contributor.authorBrady, J Jen_GB
dc.contributor.authorRogers, Ben_GB
dc.contributor.authorTormey, Wen_GB
dc.contributor.authorSmith, Den_GB
dc.contributor.authorThompson, C Jen_GB
dc.contributor.authorMcKenna, M Jen_GB
dc.contributor.authorAgha, Aen_GB
dc.date.accessioned2012-08-28T15:06:05Z-
dc.date.available2012-08-28T15:06:05Z-
dc.date.issued2011-06-
dc.identifier.citationEndocrine Reviews (2011) 32:3 Meeting Abstracts. : June 2011en_GB
dc.identifier.urihttp://hdl.handle.net/10147/240292-
dc.description.abstractThe effect of commonly used glucocorticoid replacement regimens on bone health in hypopituitary subjects is not well known. We aimed to assess the effect of 3 hydrocortisone (HC) replacement dose regimens on bone turnover in this group.10 hypopituitary men with severe ACTH deficiency were randomised in a crossover design to 3 HC dose regimens, Dose A (20mg mane, 10mg tarde), Dose B (10mg twice daily) and Dose C (10mg mane, 5mg tarde). Following 6 weeks of each regimen participants underwent fasting sampling of bone turnover markers.Data from matched controls were used to produce a Z score for subject bone formation and resorption markers and to calculate the bone remodeling balance (formation Z score-resorption Z score) and turnover index ((formation Z + resorption Z)/2). A positive bone remodeling balance with increased turnover is consistent with a favourable bone cycle. Data are expressed as median (range).The Pro Collagen Type 1 Peptide (PINP) bone formation Z-score was significantly increased in Dose C, (1.805 (-0.6-10.24)) compared to Dose A (0.035 (-1.0-8.1)) p<0.05 while there was no difference in the C-terminal crosslinking telopeptide (CTx) resorption Z score. The bone remodeling balance was significantly lower for dose A -0.02 (-1.05-4.12) compared to dose C 1.13 (0.13-6.4) (p<0.05). Although there was a trend to an increased bone turnover index with the lower dose regimen, this was not statistically significant.Low dose HC replacement (10mg mane/5 mg tarde) was associated with increased bone formation and improved bone remodeling balance which is associated with a more favourable bone cycle. This may have a long term beneficial effect on bone health.en_GB
dc.language.isoenen
dc.relation.urlhttp://edrv.endojournals.org/cgi/content/meeting_abstract/32/03_MeetingAbstracts/P2-411?sid=37055afe-3553-4704-b98c-a11f11a2777ben_GB
dc.titleLow-dose hydrocortisone (HC) replacement therapy is associated with improved bone remodeling balance in hypopituitary subjectsen_GB
dc.typeConference Presentationen
dc.identifier.journalEndocrine Reviewsen_GB
dc.description.provinceLeinsteren
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