Should children with inherited metabolic disorders receive varicella vaccination?

2.50
Hdl Handle:
http://hdl.handle.net/10147/240056
Title:
Should children with inherited metabolic disorders receive varicella vaccination?
Authors:
Varghese, M; Cafferkey, M; O'Regan, M; Monavari, A A; Treacy, E P
Affiliation:
National Centre for Inherited Metabolic Disorders, Children's University Hospital, Dublin, Ireland.
Citation:
Should children with inherited metabolic disorders receive varicella vaccination? 2011, 96 (1):99-100 Arch. Dis. Child.
Journal:
Archives of Disease in Childhood
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/240056
DOI:
10.1136/adc.2008.147934
PubMed ID:
19846994
Abstract:
The aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.
Language:
en
Keywords:
Varicella Virus; Metabolic Disorders
MeSH:
Adolescent; Chickenpox; Chickenpox Vaccine; Child; Child, Preschool; Hospitalization; Humans; Infant; Ireland; Metabolism, Inborn Errors; Vaccination
ISSN:
1468-2044

Full metadata record

DC FieldValue Language
dc.contributor.authorVarghese, Men_GB
dc.contributor.authorCafferkey, Men_GB
dc.contributor.authorO'Regan, Men_GB
dc.contributor.authorMonavari, A Aen_GB
dc.contributor.authorTreacy, E Pen_GB
dc.date.accessioned2012-08-27T13:55:54Z-
dc.date.available2012-08-27T13:55:54Z-
dc.date.issued2011-01-
dc.identifier.citationShould children with inherited metabolic disorders receive varicella vaccination? 2011, 96 (1):99-100 Arch. Dis. Child.en_GB
dc.identifier.issn1468-2044-
dc.identifier.pmid19846994-
dc.identifier.doi10.1136/adc.2008.147934-
dc.identifier.urihttp://hdl.handle.net/10147/240056-
dc.description.abstractThe aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.en_GB
dc.language.isoenen
dc.subjectVaricella Virusen_GB
dc.subjectMetabolic Disordersen_GB
dc.subject.meshAdolescent-
dc.subject.meshChickenpox-
dc.subject.meshChickenpox Vaccine-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshHospitalization-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshIreland-
dc.subject.meshMetabolism, Inborn Errors-
dc.subject.meshVaccination-
dc.titleShould children with inherited metabolic disorders receive varicella vaccination?en_GB
dc.contributor.departmentNational Centre for Inherited Metabolic Disorders, Children's University Hospital, Dublin, Ireland.en_GB
dc.identifier.journalArchives of Disease in Childhooden_GB
dc.description.provinceLeinsteren

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