Tinzaparin is safe and effective in the management of hemodialysis catheter thrombosis.

2.50
Hdl Handle:
http://hdl.handle.net/10147/239991
Title:
Tinzaparin is safe and effective in the management of hemodialysis catheter thrombosis.
Authors:
Quinlan, Catherine; Bates, Marie; Cotter, Melanie; Riordan, Michael; Waldron, Mary; Awan, Atif
Affiliation:
Department of Nephrology, The Children's University Hospital, Dublin, Ireland. CathyQuinlan@mac.com
Citation:
Tinzaparin is safe and effective in the management of hemodialysis catheter thrombosis., 58 (3):288-90 ASAIO J.
Journal:
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Issue Date:
27-Aug-2012
URI:
http://hdl.handle.net/10147/239991
DOI:
10.1097/MAT.0b013e31824c38c8
PubMed ID:
22456106
Abstract:
Children on hemodialysis are at increased risk of thrombosis, especially when dialyzed via a central venous catheter (CVC); there are limited published data regarding the safety and efficacy of tinzaparin in this group. We conducted a retrospective chart review of all children in the National Pediatric Hemodialysis Centre for Ireland diagnosed with a CVC thrombus and treated with subcutaneous tinzaparin over a 10 year period. Seven children were treated with subcutaneous tinzaparin for 10 CVC thrombi. Tinzaparin was commenced at 175 IU/kg/day and the dose was titrated by measuring anti-factor Xa levels, aiming for levels of 0.3-1.0 IU/ml. Treatment was continued until resolution of the CVC thrombus. Restoration of normal flows during dialysis occurred within 3 days in all patients. There were no episodes of bleeding and all children tolerated the treatment well.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Catheterization, Central Venous; Child; Child, Preschool; Drug Monitoring; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Infant; Renal Dialysis; Thrombosis
ISSN:
1538-943X

Full metadata record

DC FieldValue Language
dc.contributor.authorQuinlan, Catherineen_GB
dc.contributor.authorBates, Marieen_GB
dc.contributor.authorCotter, Melanieen_GB
dc.contributor.authorRiordan, Michaelen_GB
dc.contributor.authorWaldron, Maryen_GB
dc.contributor.authorAwan, Atifen_GB
dc.date.accessioned2012-08-27T07:58:38Z-
dc.date.available2012-08-27T07:58:38Z-
dc.date.issued2012-08-27-
dc.identifier.citationTinzaparin is safe and effective in the management of hemodialysis catheter thrombosis., 58 (3):288-90 ASAIO J.en_GB
dc.identifier.issn1538-943X-
dc.identifier.pmid22456106-
dc.identifier.doi10.1097/MAT.0b013e31824c38c8-
dc.identifier.urihttp://hdl.handle.net/10147/239991-
dc.description.abstractChildren on hemodialysis are at increased risk of thrombosis, especially when dialyzed via a central venous catheter (CVC); there are limited published data regarding the safety and efficacy of tinzaparin in this group. We conducted a retrospective chart review of all children in the National Pediatric Hemodialysis Centre for Ireland diagnosed with a CVC thrombus and treated with subcutaneous tinzaparin over a 10 year period. Seven children were treated with subcutaneous tinzaparin for 10 CVC thrombi. Tinzaparin was commenced at 175 IU/kg/day and the dose was titrated by measuring anti-factor Xa levels, aiming for levels of 0.3-1.0 IU/ml. Treatment was continued until resolution of the CVC thrombus. Restoration of normal flows during dialysis occurred within 3 days in all patients. There were no episodes of bleeding and all children tolerated the treatment well.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to ASAIO journal (American Society for Artificial Internal Organs : 1992)en_GB
dc.subject.meshAdolescent-
dc.subject.meshCatheterization, Central Venous-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDrug Monitoring-
dc.subject.meshFibrinolytic Agents-
dc.subject.meshHeparin, Low-Molecular-Weight-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshRenal Dialysis-
dc.subject.meshThrombosis-
dc.titleTinzaparin is safe and effective in the management of hemodialysis catheter thrombosis.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology, The Children's University Hospital, Dublin, Ireland. CathyQuinlan@mac.comen_GB
dc.identifier.journalASAIO journal (American Society for Artificial Internal Organs : 1992)en_GB
dc.description.provinceLeinsteren

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