Factors that affect mass transport from drug eluting stents into the artery wall

Hdl Handle:
http://hdl.handle.net/10147/239177
Title:
Factors that affect mass transport from drug eluting stents into the artery wall
Authors:
O'Connell, Barry M; McGloughlin, Tim M; Walsh, Michael T
Citation:
BioMedical Engineering OnLine. 2010 Mar 09;9(1):15
Issue Date:
9-Mar-2010
URI:
http://dx.doi.org/10.1186/1475-925X-9-15; http://hdl.handle.net/10147/239177
Abstract:
Abstract Coronary artery disease can be treated by implanting a stent into the blocked region of an artery, thus enabling blood perfusion to distal vessels. Minimally invasive procedures of this nature often result in damage to the arterial tissue culminating in the re-blocking of the vessel. In an effort to alleviate this phenomenon, known as restenosis, drug eluting stents were developed. They are similar in composition to a bare metal stent but encompass a coating with therapeutic agents designed to reduce the overly aggressive healing response that contributes to restenosis. There are many variables that can influence the effectiveness of these therapeutic drugs being transported from the stent coating to and within the artery wall, many of which have been analysed and documented by researchers. However, the physical deformation of the artery substructure due to stent expansion, and its influence on a drugs ability to diffuse evenly within the artery wall have been lacking in published work to date. The paper highlights previous approaches adopted by researchers and proposes the addition of porous artery wall deformation to increase model accuracy.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connell, Barry M-
dc.contributor.authorMcGloughlin, Tim M-
dc.contributor.authorWalsh, Michael T-
dc.date.accessioned2012-08-20T11:58:12Z-
dc.date.available2012-08-20T11:58:12Z-
dc.date.issued2010-03-09-
dc.identifier.citationBioMedical Engineering OnLine. 2010 Mar 09;9(1):15-
dc.identifier.urihttp://dx.doi.org/10.1186/1475-925X-9-15-
dc.identifier.urihttp://hdl.handle.net/10147/239177-
dc.description.abstractAbstract Coronary artery disease can be treated by implanting a stent into the blocked region of an artery, thus enabling blood perfusion to distal vessels. Minimally invasive procedures of this nature often result in damage to the arterial tissue culminating in the re-blocking of the vessel. In an effort to alleviate this phenomenon, known as restenosis, drug eluting stents were developed. They are similar in composition to a bare metal stent but encompass a coating with therapeutic agents designed to reduce the overly aggressive healing response that contributes to restenosis. There are many variables that can influence the effectiveness of these therapeutic drugs being transported from the stent coating to and within the artery wall, many of which have been analysed and documented by researchers. However, the physical deformation of the artery substructure due to stent expansion, and its influence on a drugs ability to diffuse evenly within the artery wall have been lacking in published work to date. The paper highlights previous approaches adopted by researchers and proposes the addition of porous artery wall deformation to increase model accuracy.-
dc.titleFactors that affect mass transport from drug eluting stents into the artery wall-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderBarry M O'Connell et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2012-08-20T11:08:33Z-
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