Developmental trajectories of fronto-executive functions in 22q11.2 deletion syndrome: A preliminary study

Hdl Handle:
http://hdl.handle.net/10147/239011
Title:
Developmental trajectories of fronto-executive functions in 22q11.2 deletion syndrome: A preliminary study
Authors:
Howley, S A; Prasad, S E; Pender, N P; Murphy, K C
Citation:
Molecular Syndromology (2011) 1:4 (206). : January 2011
Journal:
Molecular Syndromology
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/239011
Additional Links:
http://ukpmc.ac.uk/articles/PMC3042123/reload=0;jsessionid=grefmqvTmbO5DTxZl56Q.0
Abstract:
22qll.2 deletion syndrome (22qllDS) is associated with borderline-mild intellectual disability and specific neurocognitive deficits, particularly in prefrontally-mediated executive functions (EF). There is evidence for white matter abnormalities in frontal cortical regions in 22qllDS, however little is known about the development of EF across the age range. Forty-eight individuals with 22qllDS were divided into 3 age groups: Child (7 male; n = 16; 6–11 years; M (SD) age = 8.4 (1.7); mean FSIQ = 72.9); Adolescent (7 male; n = 15; 12–15 years; M (SD) age = 13.1 (0.8); mean FSIQ = 68.0) and Adult (7 male; n = 17; 16–45 years; M (SD) age = 28.8 (11.5); mean FSIQ = 69.6). Forty healthy controls were also recruited and divided into the same 3 age groups: Child (6 male; 6–11 years, n = 12; M (SD) age = 9.3 (1.7); mean FSIQ = 99.1); Adolescent (6 male; 12–15 years; n = 12; M (SD) age = 13.2 (1.1); mean FSIQ = 100.9) and Adult (6 male; 16–45 years; n = 16; M (SD) age = 28.8 (9.4); mean FSIQ = 109). All participants completed standardised tests of a range of executive functions, specifically working memory, planning, problem-solving, strategy formation, cognitive flexibility and inhibition, and cross-sectional developmental trajectories of each function were constructed. No age-mediated improvements on EF tasks were observed in the 22qllDS groups, with the exception of verbal working memory. The control group exhibited significant age-mediated improvements in working memory, strategy formation and planning efficiency. These findings support the hypothesis that 22qllDS individuals experience atypical development of neuroanatomical regions and networks associated with EF in typical individuals. Future longitudinal work is required to examine intra-individual development of executive and non-executive cognitive processes.
Item Type:
Conference Presentation
Language:
en
Keywords:
COGNITIVE FUNCTION; INTELLECTUAL DISABILITIES

Full metadata record

DC FieldValue Language
dc.contributor.authorHowley, S Aen_GB
dc.contributor.authorPrasad, S Een_GB
dc.contributor.authorPender, N Pen_GB
dc.contributor.authorMurphy, K Cen_GB
dc.date.accessioned2012-08-16T15:03:29Z-
dc.date.available2012-08-16T15:03:29Z-
dc.date.issued2011-01-
dc.identifier.citationMolecular Syndromology (2011) 1:4 (206). : January 2011en_GB
dc.identifier.urihttp://hdl.handle.net/10147/239011-
dc.description.abstract22qll.2 deletion syndrome (22qllDS) is associated with borderline-mild intellectual disability and specific neurocognitive deficits, particularly in prefrontally-mediated executive functions (EF). There is evidence for white matter abnormalities in frontal cortical regions in 22qllDS, however little is known about the development of EF across the age range. Forty-eight individuals with 22qllDS were divided into 3 age groups: Child (7 male; n = 16; 6–11 years; M (SD) age = 8.4 (1.7); mean FSIQ = 72.9); Adolescent (7 male; n = 15; 12–15 years; M (SD) age = 13.1 (0.8); mean FSIQ = 68.0) and Adult (7 male; n = 17; 16–45 years; M (SD) age = 28.8 (11.5); mean FSIQ = 69.6). Forty healthy controls were also recruited and divided into the same 3 age groups: Child (6 male; 6–11 years, n = 12; M (SD) age = 9.3 (1.7); mean FSIQ = 99.1); Adolescent (6 male; 12–15 years; n = 12; M (SD) age = 13.2 (1.1); mean FSIQ = 100.9) and Adult (6 male; 16–45 years; n = 16; M (SD) age = 28.8 (9.4); mean FSIQ = 109). All participants completed standardised tests of a range of executive functions, specifically working memory, planning, problem-solving, strategy formation, cognitive flexibility and inhibition, and cross-sectional developmental trajectories of each function were constructed. No age-mediated improvements on EF tasks were observed in the 22qllDS groups, with the exception of verbal working memory. The control group exhibited significant age-mediated improvements in working memory, strategy formation and planning efficiency. These findings support the hypothesis that 22qllDS individuals experience atypical development of neuroanatomical regions and networks associated with EF in typical individuals. Future longitudinal work is required to examine intra-individual development of executive and non-executive cognitive processes.en_GB
dc.language.isoenen
dc.relation.urlhttp://ukpmc.ac.uk/articles/PMC3042123/reload=0;jsessionid=grefmqvTmbO5DTxZl56Q.0en_GB
dc.subjectCOGNITIVE FUNCTIONen_GB
dc.subjectINTELLECTUAL DISABILITIESen_GB
dc.titleDevelopmental trajectories of fronto-executive functions in 22q11.2 deletion syndrome: A preliminary studyen_GB
dc.typeConference Presentationen
dc.identifier.journalMolecular Syndromologyen_GB
dc.description.provinceLeinsteren
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