ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.

Hdl Handle:
http://hdl.handle.net/10147/238819
Title:
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.
Authors:
Donohoe, Gary; Rose, Emma; Frodl, Thomas; Morris, Derek; Spoletini, Ilaria; Adriano, Fulvia; Bernardini, Sergio; Caltagirone, Carlo; Bossù, Paola; Gill, Michael; Corvin, Aiden P; Spalletta, Gianfranco
Affiliation:
Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland. donoghug@tcd.ie
Citation:
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia. 2011, 54 (3):2132-7 Neuroimage
Journal:
NeuroImage
Issue Date:
1-Feb-2011
URI:
http://hdl.handle.net/10147/238819
DOI:
10.1016/j.neuroimage.2010.09.089
PubMed ID:
20934520
Abstract:
ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared to patient non-carriers, we investigated whether ZNF804A was also associated with variation in brain volume. In a sample of 70 patients and 38 healthy participants we used voxel based morphometry to compare homozygous (AA) carriers of the ZNF804A risk allele to heterozygous and homozygous (AC/CC) non-carriers for both whole brain volume and specific regions implicated in earlier ZNF804A studies-the dorsolateral pre-frontal cortex, the hippocampus, and the amygdala. For patients, but not for controls, we found that homozygous 'AA' risk carriers had relatively larger gray matter volumes than heterozygous/homozygous non-carriers (AC/CC), particularly for hippocampal volumes. These data are consistent with our earlier behavioral data and suggest that ZNF804A is delineating a schizophrenia subtype characterized by relatively intact brain volume. Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk.
Item Type:
Article
Language:
en
MeSH:
Adult; Alleles; Amygdala; Brain; Cognition; Data Interpretation, Statistical; Demography; Female; Genotype; Heterozygote; Hippocampus; Humans; Image Processing, Computer-Assisted; Kruppel-Like Transcription Factors; Magnetic Resonance Imaging; Male; Memory; Polymorphism, Single Nucleotide; Prefrontal Cortex; Risk Assessment; Schizophrenia; Schizophrenic Psychology
ISSN:
1095-9572

Full metadata record

DC FieldValue Language
dc.contributor.authorDonohoe, Garyen_GB
dc.contributor.authorRose, Emmaen_GB
dc.contributor.authorFrodl, Thomasen_GB
dc.contributor.authorMorris, Dereken_GB
dc.contributor.authorSpoletini, Ilariaen_GB
dc.contributor.authorAdriano, Fulviaen_GB
dc.contributor.authorBernardini, Sergioen_GB
dc.contributor.authorCaltagirone, Carloen_GB
dc.contributor.authorBossù, Paolaen_GB
dc.contributor.authorGill, Michaelen_GB
dc.contributor.authorCorvin, Aiden Pen_GB
dc.contributor.authorSpalletta, Gianfrancoen_GB
dc.date.accessioned2012-08-15T14:21:56Z-
dc.date.available2012-08-15T14:21:56Z-
dc.date.issued2011-02-01-
dc.identifier.citationZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia. 2011, 54 (3):2132-7 Neuroimageen_GB
dc.identifier.issn1095-9572-
dc.identifier.pmid20934520-
dc.identifier.doi10.1016/j.neuroimage.2010.09.089-
dc.identifier.urihttp://hdl.handle.net/10147/238819-
dc.description.abstractZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared to patient non-carriers, we investigated whether ZNF804A was also associated with variation in brain volume. In a sample of 70 patients and 38 healthy participants we used voxel based morphometry to compare homozygous (AA) carriers of the ZNF804A risk allele to heterozygous and homozygous (AC/CC) non-carriers for both whole brain volume and specific regions implicated in earlier ZNF804A studies-the dorsolateral pre-frontal cortex, the hippocampus, and the amygdala. For patients, but not for controls, we found that homozygous 'AA' risk carriers had relatively larger gray matter volumes than heterozygous/homozygous non-carriers (AC/CC), particularly for hippocampal volumes. These data are consistent with our earlier behavioral data and suggest that ZNF804A is delineating a schizophrenia subtype characterized by relatively intact brain volume. Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to NeuroImageen_GB
dc.subject.meshAdult-
dc.subject.meshAlleles-
dc.subject.meshAmygdala-
dc.subject.meshBrain-
dc.subject.meshCognition-
dc.subject.meshData Interpretation, Statistical-
dc.subject.meshDemography-
dc.subject.meshFemale-
dc.subject.meshGenotype-
dc.subject.meshHeterozygote-
dc.subject.meshHippocampus-
dc.subject.meshHumans-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshKruppel-Like Transcription Factors-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMemory-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshPrefrontal Cortex-
dc.subject.meshRisk Assessment-
dc.subject.meshSchizophrenia-
dc.subject.meshSchizophrenic Psychology-
dc.titleZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.en_GB
dc.typeArticleen
dc.contributor.departmentNeuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland. donoghug@tcd.ieen_GB
dc.identifier.journalNeuroImageen_GB
dc.description.provinceLeinsteren

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