Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain

Hdl Handle:
http://hdl.handle.net/10147/237571
Title:
Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain
Authors:
Roche, Richard AP; Mullally, Sinéad L; McNulty, Jonathan P; Hayden, Judy; Brennan, Paul; Doherty, Colin P; Fitzsimons, Mary; McMackin, Deirdre; Prendergast, Julie; Sukumaran, Sunita; Mangaoang, Maeve A; Robertson, Ian H; O'Mara, Shane M
Citation:
BMC Neuroscience. 2009 Nov 20;10(1):136
Issue Date:
20-Nov-2009
URI:
http://dx.doi.org/10.1186/1471-2202-10-136; http://hdl.handle.net/10147/237571
Abstract:
Abstract Background Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory. We hypothesised that extended engagement of memory structures through prolonged rehearsal would result in enhanced efficacy of recall and also of brain structures implicated in new learning. Twenty-four normal participants aged 55-70 (mean = 60.1) engaged in six weeks of rote learning, during which they learned 500 words per week every week (prose, poetry etc.). An extensive battery of memory tests was administered on three occasions, each six weeks apart. In addition, proton magnetic resonance spectroscopy (1H-MRS) was used to measure metabolite levels in seven voxels of interest (VOIs) (including hippocampus) before and after learning. Results Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased. This facilitation occurred for verbal/episodic material only, and was mirrored by a metabolic change in left posterior hippocampus, specifically an increase in NAA/(Cr+Cho) ratio. Conclusion Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorRoche, Richard AP-
dc.contributor.authorMullally, Sinéad L-
dc.contributor.authorMcNulty, Jonathan P-
dc.contributor.authorHayden, Judy-
dc.contributor.authorBrennan, Paul-
dc.contributor.authorDoherty, Colin P-
dc.contributor.authorFitzsimons, Mary-
dc.contributor.authorMcMackin, Deirdre-
dc.contributor.authorPrendergast, Julie-
dc.contributor.authorSukumaran, Sunita-
dc.contributor.authorMangaoang, Maeve A-
dc.contributor.authorRobertson, Ian H-
dc.contributor.authorO'Mara, Shane M-
dc.date.accessioned2012-08-07T12:58:51Z-
dc.date.available2012-08-07T12:58:51Z-
dc.date.issued2009-11-20-
dc.identifier.citationBMC Neuroscience. 2009 Nov 20;10(1):136-
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2202-10-136-
dc.identifier.urihttp://hdl.handle.net/10147/237571-
dc.description.abstractAbstract Background Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory. We hypothesised that extended engagement of memory structures through prolonged rehearsal would result in enhanced efficacy of recall and also of brain structures implicated in new learning. Twenty-four normal participants aged 55-70 (mean = 60.1) engaged in six weeks of rote learning, during which they learned 500 words per week every week (prose, poetry etc.). An extensive battery of memory tests was administered on three occasions, each six weeks apart. In addition, proton magnetic resonance spectroscopy (1H-MRS) was used to measure metabolite levels in seven voxels of interest (VOIs) (including hippocampus) before and after learning. Results Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased. This facilitation occurred for verbal/episodic material only, and was mirrored by a metabolic change in left posterior hippocampus, specifically an increase in NAA/(Cr+Cho) ratio. Conclusion Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training.-
dc.titleProlonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderRichard AP Roche et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2012-07-25T19:07:57Z-
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