DFPE, PARTIALLY FLUORINATED ETHER: A Novel Approach for Experimental Intravitreal Tamponade.

2.50
Hdl Handle:
http://hdl.handle.net/10147/237554
Title:
DFPE, PARTIALLY FLUORINATED ETHER: A Novel Approach for Experimental Intravitreal Tamponade.
Authors:
Santos, Rodrigo A V; Keegan, David J; Fuchs, Brian S; Song, Brian J; Avila, Marcos P; Simpson, Nigel; Sparrow, Janet R; Chang, Stanley
Affiliation:
*Department of Ophthalmology, Columbia University/Harkness Eye Institute, New York, New York †Department of Ophthalmology, University of Brasília, Brasília, Brazil ‡Department of Ophthalmology, Mater Hospital, Dublin, Ireland §Department of Ophthalmology, University of Goiás, UFG, Goiânia, Brazil ¶Department of Chemistry, University of Bristol, Bristol, United Kingdom.
Citation:
DFPE, PARTIALLY FLUORINATED ETHER: A Novel Approach for Experimental Intravitreal Tamponade. 2012:notRetina
Journal:
Retina (Philadelphia, Pa.)
Issue Date:
16-Jul-2012
URI:
http://hdl.handle.net/10147/237554
DOI:
10.1097/IAE.0b013e31825db6cf
PubMed ID:
22810148
Abstract:
PURPOSE:: To evaluate decafluoro-di-n-pentyl ether (DFPE) as a vitreous tamponade by examining ocular tolerance in rabbits' eyes. METHODS:: Thirteen rabbits were divided into 4 groups after mechanical vitrectomy and were followed up to 12 months. The tamponade remained in the eye for 6 months in Group 1 (DFPE) and Group 3 (DFPE and silicone oil) and for 12 months in Group 2 (DFPE). Group 4 served as control. RESULTS:: In Groups 1, 2, and 3, dispersion of the fluid appeared 2 weeks postoperatively. Posterior subcapsular cataracts appeared in rabbits' eyes with large fills of DFPE (>50%). Histologic findings in Groups 1 and 2 showed no detectable change in outer nuclear layer thickness. Except for some vacuolations, the inner retina was well preserved in all injected rabbits' eyes. On the electroretinography of injected rabbits' eyes, there was no effect on the a wave amplitude and b wave implicit time, but the b wave amplitude was elevated with statistical significance (P < 0.001) at 1, 3, and 6 months postoperatively but with no statistical significance (P > 0.05) after that period when compared with Group 4 and unoperated fellow rabbits' eyes of each group. CONCLUSION:: Decafluoro-di-n-pentyl ether demonstrated minimum adverse effects in retinal rabbits; further studies are needed before clinical use as short-term tamponade.
Item Type:
Article
Language:
en
ISSN:
1539-2864

Full metadata record

DC FieldValue Language
dc.contributor.authorSantos, Rodrigo A Ven_GB
dc.contributor.authorKeegan, David Jen_GB
dc.contributor.authorFuchs, Brian Sen_GB
dc.contributor.authorSong, Brian Jen_GB
dc.contributor.authorAvila, Marcos Pen_GB
dc.contributor.authorSimpson, Nigelen_GB
dc.contributor.authorSparrow, Janet Ren_GB
dc.contributor.authorChang, Stanleyen_GB
dc.date.accessioned2012-08-07T12:59:53Z-
dc.date.available2012-08-07T12:59:53Z-
dc.date.issued2012-07-16-
dc.identifier.citationDFPE, PARTIALLY FLUORINATED ETHER: A Novel Approach for Experimental Intravitreal Tamponade. 2012:notRetinaen_GB
dc.identifier.issn1539-2864-
dc.identifier.pmid22810148-
dc.identifier.doi10.1097/IAE.0b013e31825db6cf-
dc.identifier.urihttp://hdl.handle.net/10147/237554-
dc.description.abstractPURPOSE:: To evaluate decafluoro-di-n-pentyl ether (DFPE) as a vitreous tamponade by examining ocular tolerance in rabbits' eyes. METHODS:: Thirteen rabbits were divided into 4 groups after mechanical vitrectomy and were followed up to 12 months. The tamponade remained in the eye for 6 months in Group 1 (DFPE) and Group 3 (DFPE and silicone oil) and for 12 months in Group 2 (DFPE). Group 4 served as control. RESULTS:: In Groups 1, 2, and 3, dispersion of the fluid appeared 2 weeks postoperatively. Posterior subcapsular cataracts appeared in rabbits' eyes with large fills of DFPE (>50%). Histologic findings in Groups 1 and 2 showed no detectable change in outer nuclear layer thickness. Except for some vacuolations, the inner retina was well preserved in all injected rabbits' eyes. On the electroretinography of injected rabbits' eyes, there was no effect on the a wave amplitude and b wave implicit time, but the b wave amplitude was elevated with statistical significance (P < 0.001) at 1, 3, and 6 months postoperatively but with no statistical significance (P > 0.05) after that period when compared with Group 4 and unoperated fellow rabbits' eyes of each group. CONCLUSION:: Decafluoro-di-n-pentyl ether demonstrated minimum adverse effects in retinal rabbits; further studies are needed before clinical use as short-term tamponade.en_GB
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to Retina (Philadelphia, Pa.)en_GB
dc.titleDFPE, PARTIALLY FLUORINATED ETHER: A Novel Approach for Experimental Intravitreal Tamponade.en_GB
dc.typeArticleen
dc.contributor.department*Department of Ophthalmology, Columbia University/Harkness Eye Institute, New York, New York †Department of Ophthalmology, University of Brasília, Brasília, Brazil ‡Department of Ophthalmology, Mater Hospital, Dublin, Ireland §Department of Ophthalmology, University of Goiás, UFG, Goiânia, Brazil ¶Department of Chemistry, University of Bristol, Bristol, United Kingdom.en_GB
dc.identifier.journalRetina (Philadelphia, Pa.)en_GB
dc.description.provinceLeinsteren

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