MicroRNAs as putative mediators of treatment response in prostate cancer.

Hdl Handle:
http://hdl.handle.net/10147/235093
Title:
MicroRNAs as putative mediators of treatment response in prostate cancer.
Authors:
O'Kelly, Fardod; Marignol, Laure; Meunier, Armelle; Lynch, Thomas H; Perry, Antoinette S; Hollywood, Donal
Affiliation:
Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, St James' Hospital & Trinity College, University of Dublin, James's Street, Dublin 8, Ireland.
Citation:
MicroRNAs as putative mediators of treatment response in prostate cancer. 2012, 9 (7):397-407 Nat Rev Urol
Journal:
Nature reviews. Urology
Issue Date:
22-May-2012
URI:
http://hdl.handle.net/10147/235093
DOI:
10.1038/nrurol.2012.104
PubMed ID:
22613932
Abstract:
MicroRNAs (miRNAs) are an abundant class of noncoding RNAs that function to regulate post-transcriptional gene expression, predominantly by translational repression. In addition to their role in prostate cancer initiation and progression, recent evidence suggests that miRNAs might also participate in treatment response across a range of therapies including radiation treatment, chemotherapy and androgen suppression. The mechanism of this regulation is thought to be multifactorial and is currently poorly understood. To date, only a small number of studies have examined the functional role of miRNAs in response to prostate cancer treatment. Elucidating the role of miRNAs in treatment response following radiotherapy, chemotherapy and androgen suppression will provide new avenues of investigation for the development of novel therapies for the treatment of prostate cancer.
Item Type:
Article
Language:
en
ISSN:
1759-4820

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Kelly, Fardoden_GB
dc.contributor.authorMarignol, Laureen_GB
dc.contributor.authorMeunier, Armelleen_GB
dc.contributor.authorLynch, Thomas Hen_GB
dc.contributor.authorPerry, Antoinette Sen_GB
dc.contributor.authorHollywood, Donalen_GB
dc.date.accessioned2012-07-23T09:22:16Z-
dc.date.available2012-07-23T09:22:16Z-
dc.date.issued2012-05-22-
dc.identifier.citationMicroRNAs as putative mediators of treatment response in prostate cancer. 2012, 9 (7):397-407 Nat Rev Urolen_GB
dc.identifier.issn1759-4820-
dc.identifier.pmid22613932-
dc.identifier.doi10.1038/nrurol.2012.104-
dc.identifier.urihttp://hdl.handle.net/10147/235093-
dc.description.abstractMicroRNAs (miRNAs) are an abundant class of noncoding RNAs that function to regulate post-transcriptional gene expression, predominantly by translational repression. In addition to their role in prostate cancer initiation and progression, recent evidence suggests that miRNAs might also participate in treatment response across a range of therapies including radiation treatment, chemotherapy and androgen suppression. The mechanism of this regulation is thought to be multifactorial and is currently poorly understood. To date, only a small number of studies have examined the functional role of miRNAs in response to prostate cancer treatment. Elucidating the role of miRNAs in treatment response following radiotherapy, chemotherapy and androgen suppression will provide new avenues of investigation for the development of novel therapies for the treatment of prostate cancer.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Nature reviews. Urologyen_GB
dc.titleMicroRNAs as putative mediators of treatment response in prostate cancer.en_GB
dc.typeArticleen
dc.contributor.departmentProstate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, St James' Hospital & Trinity College, University of Dublin, James's Street, Dublin 8, Ireland.en_GB
dc.identifier.journalNature reviews. Urologyen_GB
dc.description.provinceLeinsteren

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