The emerging role of microRNA in regulation of endotoxin tolerance.

Hdl Handle:
http://hdl.handle.net/10147/233672
Title:
The emerging role of microRNA in regulation of endotoxin tolerance.
Authors:
Quinn, Edel M; Wang, JiangHuai; Redmond, Henry P
Affiliation:
Cork University Hospital/University College Cork, Wilton, Cork, Ireland. edelquinn@rcsi.ie
Citation:
The emerging role of microRNA in regulation of endotoxin tolerance. 2012, 91 (5):721-7 J. Leukoc. Biol.
Journal:
Journal of leukocyte biology
Issue Date:
May-2012
URI:
http://hdl.handle.net/10147/233672
DOI:
10.1189/jlb.1111571
PubMed ID:
22389313
Abstract:
Endotoxin tolerance is a phenomenon where cells show reduced responsiveness toward repeated endotoxin stimulation. Regulation of tolerance occurs at multiple levels of the cell signaling cascade, and many of these levels are potentially regulated by miRNA, which are a class of small RNA that bind to mRNA to down-regulate gene expression at the post-transcriptional level. Roles have been identified for miR-146a, miR-221, miR-579, miR-125b, miR-155, let-7e, and miR-98 in regulating the TLR4 signaling pathway during the development of endotoxin tolerance at receptor, signaling pathway, and gene transcription and translational levels. miRNA represent exciting, new potential targets in attempts to exogenously modulate development of endotoxin tolerance.
Item Type:
Article
Language:
en
MeSH:
Animals; Drug Tolerance; Endotoxins; Humans; MicroRNAs; Signal Transduction; Transcription, Genetic
ISSN:
1938-3673

Full metadata record

DC FieldValue Language
dc.contributor.authorQuinn, Edel Men_GB
dc.contributor.authorWang, JiangHuaien_GB
dc.contributor.authorRedmond, Henry Pen_GB
dc.date.accessioned2012-07-13T12:56:16Z-
dc.date.available2012-07-13T12:56:16Z-
dc.date.issued2012-05-
dc.identifier.citationThe emerging role of microRNA in regulation of endotoxin tolerance. 2012, 91 (5):721-7 J. Leukoc. Biol.en_GB
dc.identifier.issn1938-3673-
dc.identifier.pmid22389313-
dc.identifier.doi10.1189/jlb.1111571-
dc.identifier.urihttp://hdl.handle.net/10147/233672-
dc.description.abstractEndotoxin tolerance is a phenomenon where cells show reduced responsiveness toward repeated endotoxin stimulation. Regulation of tolerance occurs at multiple levels of the cell signaling cascade, and many of these levels are potentially regulated by miRNA, which are a class of small RNA that bind to mRNA to down-regulate gene expression at the post-transcriptional level. Roles have been identified for miR-146a, miR-221, miR-579, miR-125b, miR-155, let-7e, and miR-98 in regulating the TLR4 signaling pathway during the development of endotoxin tolerance at receptor, signaling pathway, and gene transcription and translational levels. miRNA represent exciting, new potential targets in attempts to exogenously modulate development of endotoxin tolerance.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Journal of leukocyte biologyen_GB
dc.subject.meshAnimals-
dc.subject.meshDrug Tolerance-
dc.subject.meshEndotoxins-
dc.subject.meshHumans-
dc.subject.meshMicroRNAs-
dc.subject.meshSignal Transduction-
dc.subject.meshTranscription, Genetic-
dc.titleThe emerging role of microRNA in regulation of endotoxin tolerance.en_GB
dc.typeArticleen
dc.contributor.departmentCork University Hospital/University College Cork, Wilton, Cork, Ireland. edelquinn@rcsi.ieen_GB
dc.identifier.journalJournal of leukocyte biologyen_GB
dc.description.provinceMunsteren

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.