Lipoprotein particle distribution and skeletal muscle lipoprotein lipase activity after acute exercise

Hdl Handle:
http://hdl.handle.net/10147/232976
Title:
Lipoprotein particle distribution and skeletal muscle lipoprotein lipase activity after acute exercise
Authors:
Harrison, Michael; Moyna, Niall M; Zderic, Theodore W; O’Gorman, Donal J; McCaffrey, Noel; Carson, Brian P; Hamilton, Marc T
Citation:
Lipids in Health and Disease. 2012 Jun 06;11(1):64
Issue Date:
6-Jun-2012
URI:
http://dx.doi.org/10.1186/1476-511X-11-64; http://hdl.handle.net/10147/232976
Abstract:
AbstractBackgroundMany of the metabolic effects of exercise are due to the most recent exercise session. With recent advances in nuclear magnetic resonance spectroscopy (NMRS), it is possible to gain insight about which lipoprotein particles are responsible for mediating exercise effects.MethodsUsing a randomized cross-over design, very low density lipoprotein (VLDL) responses were evaluated in eight men on the morning after i) an inactive control trial (CON), ii) exercising vigorously on the prior evening for 100 min followed by fasting overnight to maintain an energy and carbohydrate deficit (EX-DEF), and iii) after the same exercise session followed by carbohydrate intake to restore muscle glycogen and carbohydrate balance (EX-BAL).ResultsThe intermediate, low and high density lipoprotein particle concentrations did not differ between trials. Fasting triglyceride (TG) determined biochemically, and mean VLDL size were lower in EX-DEF but not in EX-BAL compared to CON, primarily due to a reduction in VLDL-TG in the 70–120 nm (large) particle range. In contrast, VLDL-TG was lower in both EX-DEF and EX-BAL compared to CON in the 43–55 nm (medium) particle range. VLDL-TG in smaller particles (29–43 nm) was unaffected by exercise. Because the majority of VLDL particles were in this smallest size range and resistant to change, total VLDL particle concentration was not different between any of these conditions. Skeletal muscle lipoprotein lipase (LPL) activity was also not different across these 3 trials. However, in CON only, the inter-individual differences in LPL activity were inversely correlated with fasting TG, VLDL-TG, total, large and small VLDL particle concentration and VLDL size, indicating a regulatory role for LPL in the non-exercised state.ConclusionsThese findings reveal a high level of differential regulation between different sized triglyceride-rich lipoproteins following exercise and feeding, in the absence of changes in LPL activity.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorHarrison, Michael-
dc.contributor.authorMoyna, Niall M-
dc.contributor.authorZderic, Theodore W-
dc.contributor.authorO’Gorman, Donal J-
dc.contributor.authorMcCaffrey, Noel-
dc.contributor.authorCarson, Brian P-
dc.contributor.authorHamilton, Marc T-
dc.date.accessioned2012-07-10T14:20:25Z-
dc.date.available2012-07-10T14:20:25Z-
dc.date.issued2012-06-06-
dc.identifier.citationLipids in Health and Disease. 2012 Jun 06;11(1):64-
dc.identifier.urihttp://dx.doi.org/10.1186/1476-511X-11-64-
dc.identifier.urihttp://hdl.handle.net/10147/232976-
dc.description.abstractAbstractBackgroundMany of the metabolic effects of exercise are due to the most recent exercise session. With recent advances in nuclear magnetic resonance spectroscopy (NMRS), it is possible to gain insight about which lipoprotein particles are responsible for mediating exercise effects.MethodsUsing a randomized cross-over design, very low density lipoprotein (VLDL) responses were evaluated in eight men on the morning after i) an inactive control trial (CON), ii) exercising vigorously on the prior evening for 100 min followed by fasting overnight to maintain an energy and carbohydrate deficit (EX-DEF), and iii) after the same exercise session followed by carbohydrate intake to restore muscle glycogen and carbohydrate balance (EX-BAL).ResultsThe intermediate, low and high density lipoprotein particle concentrations did not differ between trials. Fasting triglyceride (TG) determined biochemically, and mean VLDL size were lower in EX-DEF but not in EX-BAL compared to CON, primarily due to a reduction in VLDL-TG in the 70–120 nm (large) particle range. In contrast, VLDL-TG was lower in both EX-DEF and EX-BAL compared to CON in the 43–55 nm (medium) particle range. VLDL-TG in smaller particles (29–43 nm) was unaffected by exercise. Because the majority of VLDL particles were in this smallest size range and resistant to change, total VLDL particle concentration was not different between any of these conditions. Skeletal muscle lipoprotein lipase (LPL) activity was also not different across these 3 trials. However, in CON only, the inter-individual differences in LPL activity were inversely correlated with fasting TG, VLDL-TG, total, large and small VLDL particle concentration and VLDL size, indicating a regulatory role for LPL in the non-exercised state.ConclusionsThese findings reveal a high level of differential regulation between different sized triglyceride-rich lipoproteins following exercise and feeding, in the absence of changes in LPL activity.-
dc.titleLipoprotein particle distribution and skeletal muscle lipoprotein lipase activity after acute exercise-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderMichael Harrison et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2012-07-10T11:14:37Z-
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