Modern oncologic and operative outcomes for oesophageal cancer treated with curative intent.

Hdl Handle:
http://hdl.handle.net/10147/232932
Title:
Modern oncologic and operative outcomes for oesophageal cancer treated with curative intent.
Authors:
Reynolds, J V; McGillycuddy, E; Ravi, N; Donohoe, C; O'Toole, D; O'Byrne, K; Hollywood, D
Affiliation:
Department of Surgery, St James's Hospital, James's St, Dublin 8. reynoljv@tcd.ie
Citation:
Modern oncologic and operative outcomes for oesophageal cancer treated with curative intent. 2011, 104 (8):235-8 Ir Med J
Publisher:
Irish Medical Journal (IMJ)
Journal:
Irish medical journal
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10147/232932
PubMed ID:
22125876
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/22125876
Abstract:
The curative approach to oesophageal cancer carries significant risks and a cure is achieved in approximately 20 per cent. There has been a recent trend internationally to observe improved operative and oncological outcomes. This report audits modern outcomes from a high volume centre with a prospective database for the period 2004-08. 603 patients were referred and 310 (52%) were treated with curative intent. Adenocarcinoma represented 68% of the cohort, squamous cell cancer 30%. Of the 310 cases, 227 (73%) underwent surgery, 105 (46%) underwent surgery alone, and 122 (54%) had chemotherapy or combination chemotherapy and radiation therapy. The postoperative mortality rate was 1.7%. The median and 5-year survival of the 310 patients based on intention to treat was 36 months and 36%, respectively, and of the 181 patients undergoing R0 resection, 52 months and 42%, respectively. An in-hospital postoperative mortality rate of less than 2 per cent, and 5-year survival of between 35 and 42% is consistent with benchmarks from international series.
Item Type:
Article
Language:
en
MeSH:
Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chi-Square Distribution; Combined Modality Therapy; Esophageal Neoplasms; Female; Hospital Mortality; Humans; Ireland; Male; Middle Aged; Prospective Studies; Statistics, Nonparametric; Survival Rate
ISSN:
0332-3102

Full metadata record

DC FieldValue Language
dc.contributor.authorReynolds, J Ven_GB
dc.contributor.authorMcGillycuddy, Een_GB
dc.contributor.authorRavi, Nen_GB
dc.contributor.authorDonohoe, Cen_GB
dc.contributor.authorO'Toole, Den_GB
dc.contributor.authorO'Byrne, Ken_GB
dc.contributor.authorHollywood, Den_GB
dc.date.accessioned2012-07-10T13:49:17Z-
dc.date.available2012-07-10T13:49:17Z-
dc.date.issued2011-09-
dc.identifier.citationModern oncologic and operative outcomes for oesophageal cancer treated with curative intent. 2011, 104 (8):235-8 Ir Med Jen_GB
dc.identifier.issn0332-3102-
dc.identifier.pmid22125876-
dc.identifier.urihttp://hdl.handle.net/10147/232932-
dc.description.abstractThe curative approach to oesophageal cancer carries significant risks and a cure is achieved in approximately 20 per cent. There has been a recent trend internationally to observe improved operative and oncological outcomes. This report audits modern outcomes from a high volume centre with a prospective database for the period 2004-08. 603 patients were referred and 310 (52%) were treated with curative intent. Adenocarcinoma represented 68% of the cohort, squamous cell cancer 30%. Of the 310 cases, 227 (73%) underwent surgery, 105 (46%) underwent surgery alone, and 122 (54%) had chemotherapy or combination chemotherapy and radiation therapy. The postoperative mortality rate was 1.7%. The median and 5-year survival of the 310 patients based on intention to treat was 36 months and 36%, respectively, and of the 181 patients undergoing R0 resection, 52 months and 42%, respectively. An in-hospital postoperative mortality rate of less than 2 per cent, and 5-year survival of between 35 and 42% is consistent with benchmarks from international series.-
dc.language.isoenen
dc.publisherIrish Medical Journal (IMJ)en_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22125876en_GB
dc.rightsArchived with thanks to Irish medical journalen_GB
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshChi-Square Distribution-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHospital Mortality-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshProspective Studies-
dc.subject.meshStatistics, Nonparametric-
dc.subject.meshSurvival Rate-
dc.titleModern oncologic and operative outcomes for oesophageal cancer treated with curative intent.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, St James's Hospital, James's St, Dublin 8. reynoljv@tcd.ieen_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinster-

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