The effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model.

Hdl Handle:
http://hdl.handle.net/10147/231535
Title:
The effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model.
Authors:
Gibbons, Aileen; Padilla-Carlin, Danielle; Kelly, Ciara; Hickey, Anthony J; Taggart, Clifford; McElvaney, Noel G; Cryan, Sally-Ann
Affiliation:
School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland.
Citation:
The effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model. 2011, 28 (9):2233-45 Pharm. Res.
Journal:
Pharmaceutical research
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10147/231535
DOI:
10.1007/s11095-011-0454-1
PubMed ID:
21647791
Additional Links:
http://epubs.rcsi.ie/cgi/viewcontent.cgi?article=1002&context=spharmart&sei-redir=1&referer=http%3A%2F%2Fwww.google.ie%2Furl%3Fsa%3Dt%26rct%3Dj%26q%3Dthe%2520effect%2520of%2520liposome%2520encapsulation%2520on%2520the%2520pharmacokinetics%2520of%2520recombinant%2520secretory%2520leukocyte%2520protease%2520inhibitor%2520%28rslpi%29%2520therapy%2520after%2520local%2520delivery%2520to%2520a%2520guinea%2520pig%2520asthma%2520model%26source%3Dweb%26cd%3D2%26ved%3D0CFAQFjAB%26url%3Dhttp%253A%252F%252Fepubs.rcsi.ie%252Fcgi%252Fviewcontent.cgi%253Farticle%253D1002%2526context%253Dspharmart%26ei%3D0WjtT6mhAdSJhQeEs738DA%26usg%3DAFQjCNHW_MJL9zjdx8NHGIhykaqTjGqIIQ#search=%22effect%20liposome%20encapsulation%20pharmacokinetics%20recombinant%20secretory%20leukocyte%20protease%20inhibitor%20%28rslpi%29%20therapy%20after%20local%20delivery%20guinea%20pig%20asthma%20model%22
Abstract:
Inhaled recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) has shown potential for treatment of inflammatory lung conditions. Rapid inactivation of rSLPI by cathepsin L (Cat L) and rapid clearance from the lungs have limited clinical efficacy. Encapsulation of rSLPI within 1,2-Dioleoyl-sn-Glycero-3-[Phospho-L-Serine]:Cholesterol liposomes (DOPS-rSLPI) protects rSLPI against Cat L inactivation in vitro. We aimed to determine the effect of liposomes on rSLPI pharmacokinetics and activity in vitro and after local delivery to the airways in vivo.
Item Type:
Article
Language:
en
MeSH:
Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Biological Transport; Cell Line; Cell Membrane Permeability; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Drug Stability; Electric Impedance; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Humans; Liposomes; Male; Respiratory Mucosa; Secretory Leukocyte Peptidase Inhibitor
ISSN:
1573-904X

Full metadata record

DC FieldValue Language
dc.contributor.authorGibbons, Aileenen_GB
dc.contributor.authorPadilla-Carlin, Danielleen_GB
dc.contributor.authorKelly, Ciaraen_GB
dc.contributor.authorHickey, Anthony Jen_GB
dc.contributor.authorTaggart, Clifforden_GB
dc.contributor.authorMcElvaney, Noel Gen_GB
dc.contributor.authorCryan, Sally-Annen_GB
dc.date.accessioned2012-06-29T14:09:54Z-
dc.date.available2012-06-29T14:09:54Z-
dc.date.issued2011-09-
dc.identifier.citationThe effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model. 2011, 28 (9):2233-45 Pharm. Res.en_GB
dc.identifier.issn1573-904X-
dc.identifier.pmid21647791-
dc.identifier.doi10.1007/s11095-011-0454-1-
dc.identifier.urihttp://hdl.handle.net/10147/231535-
dc.description.abstractInhaled recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) has shown potential for treatment of inflammatory lung conditions. Rapid inactivation of rSLPI by cathepsin L (Cat L) and rapid clearance from the lungs have limited clinical efficacy. Encapsulation of rSLPI within 1,2-Dioleoyl-sn-Glycero-3-[Phospho-L-Serine]:Cholesterol liposomes (DOPS-rSLPI) protects rSLPI against Cat L inactivation in vitro. We aimed to determine the effect of liposomes on rSLPI pharmacokinetics and activity in vitro and after local delivery to the airways in vivo.en_GB
dc.language.isoenen
dc.relation.urlhttp://epubs.rcsi.ie/cgi/viewcontent.cgi?article=1002&context=spharmart&sei-redir=1&referer=http%3A%2F%2Fwww.google.ie%2Furl%3Fsa%3Dt%26rct%3Dj%26q%3Dthe%2520effect%2520of%2520liposome%2520encapsulation%2520on%2520the%2520pharmacokinetics%2520of%2520recombinant%2520secretory%2520leukocyte%2520protease%2520inhibitor%2520%28rslpi%29%2520therapy%2520after%2520local%2520delivery%2520to%2520a%2520guinea%2520pig%2520asthma%2520model%26source%3Dweb%26cd%3D2%26ved%3D0CFAQFjAB%26url%3Dhttp%253A%252F%252Fepubs.rcsi.ie%252Fcgi%252Fviewcontent.cgi%253Farticle%253D1002%2526context%253Dspharmart%26ei%3D0WjtT6mhAdSJhQeEs738DA%26usg%3DAFQjCNHW_MJL9zjdx8NHGIhykaqTjGqIIQ#search=%22effect%20liposome%20encapsulation%20pharmacokinetics%20recombinant%20secretory%20leukocyte%20protease%20inhibitor%20%28rslpi%29%20therapy%20after%20local%20delivery%20guinea%20pig%20asthma%20model%22en_GB
dc.rightsArchived with thanks to Pharmaceutical researchen_GB
dc.subject.meshAdministration, Inhalation-
dc.subject.meshAnimals-
dc.subject.meshAnti-Asthmatic Agents-
dc.subject.meshAsthma-
dc.subject.meshBiological Transport-
dc.subject.meshCell Line-
dc.subject.meshCell Membrane Permeability-
dc.subject.meshDisease Models, Animal-
dc.subject.meshDrug Compounding-
dc.subject.meshDrug Delivery Systems-
dc.subject.meshDrug Stability-
dc.subject.meshElectric Impedance-
dc.subject.meshEnzyme-Linked Immunosorbent Assay-
dc.subject.meshGuinea Pigs-
dc.subject.meshHumans-
dc.subject.meshLiposomes-
dc.subject.meshMale-
dc.subject.meshRespiratory Mucosa-
dc.subject.meshSecretory Leukocyte Peptidase Inhibitor-
dc.titleThe effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model.en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland.en_GB
dc.identifier.journalPharmaceutical researchen_GB
dc.description.provinceLeinsteren

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