Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.

Hdl Handle:
http://hdl.handle.net/10147/231513
Title:
Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.
Authors:
Hassan, Tidi; McKiernan, Paul J; McElvaney, Noel G; Cryan, Sally Ann; Greene, Catherine M
Affiliation:
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Citation:
Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. 2012, 10 (3):359-68 Expert Rev Anti Infect Ther
Journal:
Expert review of anti-infective therapy
Issue Date:
Mar-2012
URI:
http://hdl.handle.net/10147/231513
DOI:
10.1586/eri.11.175
PubMed ID:
22397568
Abstract:
miRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.
Item Type:
Article
Language:
en
MeSH:
Gene Expression Regulation; Gene Targeting; Humans; Immunity, Innate; Inflammation; Lung Diseases; MicroRNAs
ISSN:
1744-8336

Full metadata record

DC FieldValue Language
dc.contributor.authorHassan, Tidien_GB
dc.contributor.authorMcKiernan, Paul Jen_GB
dc.contributor.authorMcElvaney, Noel Gen_GB
dc.contributor.authorCryan, Sally Annen_GB
dc.contributor.authorGreene, Catherine Men_GB
dc.date.accessioned2012-06-29T14:11:20Z-
dc.date.available2012-06-29T14:11:20Z-
dc.date.issued2012-03-
dc.identifier.citationTherapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. 2012, 10 (3):359-68 Expert Rev Anti Infect Theren_GB
dc.identifier.issn1744-8336-
dc.identifier.pmid22397568-
dc.identifier.doi10.1586/eri.11.175-
dc.identifier.urihttp://hdl.handle.net/10147/231513-
dc.description.abstractmiRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Expert review of anti-infective therapyen_GB
dc.subject.meshGene Expression Regulation-
dc.subject.meshGene Targeting-
dc.subject.meshHumans-
dc.subject.meshImmunity, Innate-
dc.subject.meshInflammation-
dc.subject.meshLung Diseases-
dc.subject.meshMicroRNAs-
dc.titleTherapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.en_GB
dc.typeArticleen
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.en_GB
dc.identifier.journalExpert review of anti-infective therapyen_GB
dc.description.provinceLeinsteren

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