Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.
Affiliation
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.Issue Date
2012-03MeSH
Gene Expression RegulationGene Targeting
Humans
Immunity, Innate
Inflammation
Lung Diseases
MicroRNAs
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Show full item recordCitation
Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. 2012, 10 (3):359-68 Expert Rev Anti Infect TherJournal
Expert review of anti-infective therapyDOI
10.1586/eri.11.175PubMed ID
22397568Abstract
miRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.Item Type
ArticleLanguage
enISSN
1744-8336ae974a485f413a2113503eed53cd6c53
10.1586/eri.11.175
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