Psychotic-like experiences in the general population: characterizing a high-risk group for psychosis.

Hdl Handle:
http://hdl.handle.net/10147/231057
Title:
Psychotic-like experiences in the general population: characterizing a high-risk group for psychosis.
Authors:
Kelleher, I; Cannon, M
Citation:
Psychotic-like experiences in the general population: characterizing a high-risk group for psychosis. 2011, 41 (1):1-6 Psychol Med
Journal:
Psychological medicine
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/231057
DOI:
10.1017/S0033291710001005
PubMed ID:
20624328
Additional Links:
http://epubs.rcsi.ie/cgi/viewcontent.cgi?article=1001&context=psychart&sei-redir=1&referer=http%3A%2F%2Fwww.google.ie%2Furl%3Fsa%3Dt%26rct%3Dj%26q%3Dpsychotic-like%2520experiences%2520in%2520the%2520general%2520population%253A%2520characterizing%2520a%2520high-risk%2520group%2520for%2520psychosis%26source%3Dweb%26cd%3D3%26ved%3D0CFYQFjAC%26url%3Dhttp%253A%252F%252Fepubs.rcsi.ie%252Fcgi%252Fviewcontent.cgi%253Farticle%253D1001%2526context%253Dpsychart%26ei%3DDBDrT7CNAcS3hQe796TSBQ%26usg%3DAFQjCNH0o0npdFDdE-zfi3zNOMtw-VAIxg#search=%22psychotic-like%20experiences%20general%20population%3A%20characterizing%20high-risk%20group%20psychosis%22
Abstract:
Recent research shows that psychotic symptoms, or psychotic-like experiences (PLEs), are reported not only by psychosis patients but also by healthy members of the general population. Healthy individuals who report these symptoms are considered to represent a non-clinical psychosis phenotype, and have been demonstrated to be at increased risk of schizophrenia-spectrum disorder. Converging research now shows that this non-clinical psychosis phenotype is familial, heritable and covaries with familial schizophrenia-spectrum disorder. A review of the research also shows that the non-clinical phenotype is associated extensively with schizophrenia-related risk factors, including social, environmental, substance use, obstetric, developmental, anatomical, motor, cognitive, linguistic, intellectual and psychopathological risk factors. The criterion and construct validity of the non-clinical psychosis phenotype with schizophrenia demonstrates that it is a valid population in which to study the aetiology of psychosis. Furthermore, it suggests shared genetic variation between the clinical and non-clinical phenotypes. Much remains to be learned about psychosis by broadening the scope of research to include the non-clinical psychosis phenotype.
Item Type:
Article
Language:
en
MeSH:
Humans; Phenotype; Psychotic Disorders; Risk Factors; Schizophrenia
ISSN:
1469-8978

Full metadata record

DC FieldValue Language
dc.contributor.authorKelleher, Ien_GB
dc.contributor.authorCannon, Men_GB
dc.date.accessioned2012-06-27T15:26:10Z-
dc.date.available2012-06-27T15:26:10Z-
dc.date.issued2011-01-
dc.identifier.citationPsychotic-like experiences in the general population: characterizing a high-risk group for psychosis. 2011, 41 (1):1-6 Psychol Meden_GB
dc.identifier.issn1469-8978-
dc.identifier.pmid20624328-
dc.identifier.doi10.1017/S0033291710001005-
dc.identifier.urihttp://hdl.handle.net/10147/231057-
dc.description.abstractRecent research shows that psychotic symptoms, or psychotic-like experiences (PLEs), are reported not only by psychosis patients but also by healthy members of the general population. Healthy individuals who report these symptoms are considered to represent a non-clinical psychosis phenotype, and have been demonstrated to be at increased risk of schizophrenia-spectrum disorder. Converging research now shows that this non-clinical psychosis phenotype is familial, heritable and covaries with familial schizophrenia-spectrum disorder. A review of the research also shows that the non-clinical phenotype is associated extensively with schizophrenia-related risk factors, including social, environmental, substance use, obstetric, developmental, anatomical, motor, cognitive, linguistic, intellectual and psychopathological risk factors. The criterion and construct validity of the non-clinical psychosis phenotype with schizophrenia demonstrates that it is a valid population in which to study the aetiology of psychosis. Furthermore, it suggests shared genetic variation between the clinical and non-clinical phenotypes. Much remains to be learned about psychosis by broadening the scope of research to include the non-clinical psychosis phenotype.en_GB
dc.language.isoenen
dc.relation.urlhttp://epubs.rcsi.ie/cgi/viewcontent.cgi?article=1001&context=psychart&sei-redir=1&referer=http%3A%2F%2Fwww.google.ie%2Furl%3Fsa%3Dt%26rct%3Dj%26q%3Dpsychotic-like%2520experiences%2520in%2520the%2520general%2520population%253A%2520characterizing%2520a%2520high-risk%2520group%2520for%2520psychosis%26source%3Dweb%26cd%3D3%26ved%3D0CFYQFjAC%26url%3Dhttp%253A%252F%252Fepubs.rcsi.ie%252Fcgi%252Fviewcontent.cgi%253Farticle%253D1001%2526context%253Dpsychart%26ei%3DDBDrT7CNAcS3hQe796TSBQ%26usg%3DAFQjCNH0o0npdFDdE-zfi3zNOMtw-VAIxg#search=%22psychotic-like%20experiences%20general%20population%3A%20characterizing%20high-risk%20group%20psychosis%22en_GB
dc.rightsArchived with thanks to Psychological medicineen_GB
dc.subject.meshHumans-
dc.subject.meshPhenotype-
dc.subject.meshPsychotic Disorders-
dc.subject.meshRisk Factors-
dc.subject.meshSchizophrenia-
dc.titlePsychotic-like experiences in the general population: characterizing a high-risk group for psychosis.en_GB
dc.typeArticleen
dc.identifier.journalPsychological medicineen_GB
dc.description.provinceLeinsteren

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