Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects.

Hdl Handle:
http://hdl.handle.net/10147/231051
Title:
Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects.
Authors:
Ashley, David T; O'Sullivan, Eoin P; Davenport, Colin; Devlin, Niamh; Crowley, Rachel K; McCaffrey, Noel; Moyna, Niall M; Smith, Diarmuid; O'Gorman, Donal J
Affiliation:
Centre for Preventive Medicine, Dublin City University, Dublin 9, Ireland.
Citation:
Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects. 2011, 60 (7):994-1000 Metab. Clin. Exp.
Journal:
Metabolism: clinical and experimental
Issue Date:
Jul-2011
URI:
http://hdl.handle.net/10147/231051
DOI:
10.1016/j.metabol.2010.10.001
PubMed ID:
21087777
Abstract:
An increase in serum osteoprotegerin (OPG) is associated with type 2 diabetes mellitus, the severity of vascular calcification, and coronary artery disease. Obesity is a risk factor for diabetes and cardiovascular disease, but little is known about the relationship between OPG and obesity. The purpose of this study was to determine if changes in body mass index (BMI) and insulin sensitivity influence circulating OPG in healthy subjects. A total of 100 subjects (36 lean, 41 overweight, and 23 obese) with normal glucose tolerance, blood pressure, and electrocardiogram stress test result volunteered for this study. Insulin sensitivity was estimated using a 2-hour oral glucose tolerance test with oral glucose insulin sensitivity analysis. Osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),soluble receptor activator of nuclear factor-κβ ligand (sRANKL), and adiponectin were analyzed using commercially available enzyme-linked immunosorbent assays. Osteoprotegerin (P < .01) and adiponectin (P < .001) were significantly decreased in the obese compared with lean subjects. There was no significant difference between BMI categories for TRAIL or sRANKL. Controlling for age and sex, there was a significant correlation between OPG and adiponectin (r = 0.391, P < .001), BMI (r = -0.331, P < .001), waist circumference (r = -0.268, P < .01), homeostasis model assessment of insulin resistance (r = -0.222, P < .05), and oral glucose insulin sensitivity (r = 0.221, P < .05). Both OPG and adiponectin were negatively correlated with body weight, BMI, waist circumference, and fasting plasma insulin while being positively correlated with insulin sensitivity (P < .05). Controlling for age, sex, and BMI, TRAIL was positively related to fat mass (r = 0.373, P < .001) and waist circumference (r = 0.257, P < .05). In contrast to patients with type 2 diabetes mellitus, circulating OPG is lower in obese, but otherwise healthy subjects and is positively correlated with indices of insulin sensitivity.
Item Type:
Article
Language:
en
MeSH:
Adiponectin; Adult; Blood Pressure; Body Mass Index; Cohort Studies; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Middle Aged; Obesity; Osteoprotegerin; RANK Ligand; TNF-Related Apoptosis-Inducing Ligand; Waist Circumference
ISSN:
1532-8600

Full metadata record

DC FieldValue Language
dc.contributor.authorAshley, David Ten_GB
dc.contributor.authorO'Sullivan, Eoin Pen_GB
dc.contributor.authorDavenport, Colinen_GB
dc.contributor.authorDevlin, Niamhen_GB
dc.contributor.authorCrowley, Rachel Ken_GB
dc.contributor.authorMcCaffrey, Noelen_GB
dc.contributor.authorMoyna, Niall Men_GB
dc.contributor.authorSmith, Diarmuiden_GB
dc.contributor.authorO'Gorman, Donal Jen_GB
dc.date.accessioned2012-06-27T14:34:46Z-
dc.date.available2012-06-27T14:34:46Z-
dc.date.issued2011-07-
dc.identifier.citationSimilar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects. 2011, 60 (7):994-1000 Metab. Clin. Exp.en_GB
dc.identifier.issn1532-8600-
dc.identifier.pmid21087777-
dc.identifier.doi10.1016/j.metabol.2010.10.001-
dc.identifier.urihttp://hdl.handle.net/10147/231051-
dc.description.abstractAn increase in serum osteoprotegerin (OPG) is associated with type 2 diabetes mellitus, the severity of vascular calcification, and coronary artery disease. Obesity is a risk factor for diabetes and cardiovascular disease, but little is known about the relationship between OPG and obesity. The purpose of this study was to determine if changes in body mass index (BMI) and insulin sensitivity influence circulating OPG in healthy subjects. A total of 100 subjects (36 lean, 41 overweight, and 23 obese) with normal glucose tolerance, blood pressure, and electrocardiogram stress test result volunteered for this study. Insulin sensitivity was estimated using a 2-hour oral glucose tolerance test with oral glucose insulin sensitivity analysis. Osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),soluble receptor activator of nuclear factor-κβ ligand (sRANKL), and adiponectin were analyzed using commercially available enzyme-linked immunosorbent assays. Osteoprotegerin (P < .01) and adiponectin (P < .001) were significantly decreased in the obese compared with lean subjects. There was no significant difference between BMI categories for TRAIL or sRANKL. Controlling for age and sex, there was a significant correlation between OPG and adiponectin (r = 0.391, P < .001), BMI (r = -0.331, P < .001), waist circumference (r = -0.268, P < .01), homeostasis model assessment of insulin resistance (r = -0.222, P < .05), and oral glucose insulin sensitivity (r = 0.221, P < .05). Both OPG and adiponectin were negatively correlated with body weight, BMI, waist circumference, and fasting plasma insulin while being positively correlated with insulin sensitivity (P < .05). Controlling for age, sex, and BMI, TRAIL was positively related to fat mass (r = 0.373, P < .001) and waist circumference (r = 0.257, P < .05). In contrast to patients with type 2 diabetes mellitus, circulating OPG is lower in obese, but otherwise healthy subjects and is positively correlated with indices of insulin sensitivity.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Metabolism: clinical and experimentalen_GB
dc.subject.meshAdiponectin-
dc.subject.meshAdult-
dc.subject.meshBlood Pressure-
dc.subject.meshBody Mass Index-
dc.subject.meshCohort Studies-
dc.subject.meshDiabetes Mellitus, Type 2-
dc.subject.meshFemale-
dc.subject.meshGlucose Tolerance Test-
dc.subject.meshHumans-
dc.subject.meshInsulin Resistance-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshObesity-
dc.subject.meshOsteoprotegerin-
dc.subject.meshRANK Ligand-
dc.subject.meshTNF-Related Apoptosis-Inducing Ligand-
dc.subject.meshWaist Circumference-
dc.titleSimilar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects.en_GB
dc.typeArticleen
dc.contributor.departmentCentre for Preventive Medicine, Dublin City University, Dublin 9, Ireland.en_GB
dc.identifier.journalMetabolism: clinical and experimentalen_GB
dc.description.provinceLeinsteren

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