Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801.

Hdl Handle:
http://hdl.handle.net/10147/230659
Title:
Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801.
Authors:
Robinson, G B
Affiliation:
Department of Psychology, University of New Brunswick, Fredericton, Canada.
Citation:
Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801. 1991, 562 (1):26-33 Brain Res.
Journal:
Brain research
Issue Date:
18-Oct-1991
URI:
http://hdl.handle.net/10147/230659
PubMed ID:
1799870
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142158/pdf/pone.0022489.pdf; http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022489
Abstract:
The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment continued for the first 10 days of kindling. MK-801 depressed the growth of the afterdischarge duration and suppressed development of behavioral seizures. MK-801 did not block kindling-induced potentiation of either the perforant path-dentate granule cell population spike or excitatory postsynaptic potential. Random impulse train stimulation and non-linear systems analytic techniques were used to examine kindling-induced potentiation of presumed GABAergic recurrent inhibitory circuits. Both the magnitude and duration of kindling-induced response inhibition, to the second of each pair of impulses within the train, were reduced in rabbits pretreated with MK-801. These results suggest that MK-801 differentially affects kindling-induced potentiation of excitatory and inhibitory circuits within the rabbit hippocampal dentate gyrus.
Item Type:
Article
Language:
en
MeSH:
Analysis of Variance; Animals; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Rabbits; Seizures
ISSN:
0006-8993

Full metadata record

DC FieldValue Language
dc.contributor.authorRobinson, G Ben_GB
dc.date.accessioned2012-06-25T16:26:11Z-
dc.date.available2012-06-25T16:26:11Z-
dc.date.issued1991-10-18-
dc.identifier.citationKindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801. 1991, 562 (1):26-33 Brain Res.en_GB
dc.identifier.issn0006-8993-
dc.identifier.pmid1799870-
dc.identifier.urihttp://hdl.handle.net/10147/230659-
dc.description.abstractThe effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment continued for the first 10 days of kindling. MK-801 depressed the growth of the afterdischarge duration and suppressed development of behavioral seizures. MK-801 did not block kindling-induced potentiation of either the perforant path-dentate granule cell population spike or excitatory postsynaptic potential. Random impulse train stimulation and non-linear systems analytic techniques were used to examine kindling-induced potentiation of presumed GABAergic recurrent inhibitory circuits. Both the magnitude and duration of kindling-induced response inhibition, to the second of each pair of impulses within the train, were reduced in rabbits pretreated with MK-801. These results suggest that MK-801 differentially affects kindling-induced potentiation of excitatory and inhibitory circuits within the rabbit hippocampal dentate gyrus.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142158/pdf/pone.0022489.pdfen_GB
dc.relation.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022489en_GB
dc.rightsArchived with thanks to Brain researchen_GB
dc.subject.meshAnalysis of Variance-
dc.subject.meshAnimals-
dc.subject.meshDizocilpine Maleate-
dc.subject.meshElectric Stimulation-
dc.subject.meshEvoked Potentials-
dc.subject.meshHippocampus-
dc.subject.meshKindling, Neurologic-
dc.subject.meshMale-
dc.subject.meshN-Methylaspartate-
dc.subject.meshRabbits-
dc.subject.meshSeizures-
dc.titleKindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Psychology, University of New Brunswick, Fredericton, Canada.en_GB
dc.identifier.journalBrain researchen_GB
dc.description.provinceLeinsteren
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