PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma

Hdl Handle:
http://hdl.handle.net/10147/230656
Title:
PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma
Authors:
Keld, R; Guo, B; Downey, P; Cummins, R; Gulmann, C; Ang, Y S; Sharrocks, A D
Citation:
PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma 2011, 105 (1):124 British Journal of Cancer
Journal:
British Journal of Cancer
Issue Date:
28-Jun-2011
URI:
http://hdl.handle.net/10147/230656
DOI:
10.1038/bjc.2011.187
Additional Links:
http://www.nature.com/doifinder/10.1038/bjc.2011.187; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137405/pdf/bjc2011187a.pdf
Abstract:
Background: Transcription factors often play important roles in tumourigenesis. Members of the PEA3 subfamily of ETS-domain transcription factors fulfil such a role and have been associated with tumour metastasis in several different cancers. Moreover, the activity of the PEA3 subfamily transcription factors is potentiated by Ras-ERK pathway signalling, which is itself often deregulated in tumour cells. Methods: Immunohistochemical patterns of PEA3 expression and active ERK signalling were analysed and mRNA expression levels of PEA3, ER81, MMP-1 and MMP-7 were determined in gastric adenocarcinoma samples. Results: Here, we have studied the expression of the PEA3 subfamily members PEA3/ETV4 and ER81/ETV1 in gastric adenocarcinomas. PEA3 is upregulated at the protein level in gastric adenocarcinomas and both PEA3/ETV4 and ER81/ETV1 are upregulated at the mRNA level in gastric adenocarcinoma tissues. This increased expression correlates with the expression of a target gene associated with metastasis, MMP-1. Enhanced ERK signalling is also more prevalent in late-stage gastric adenocarcinomas, and the co-association of ERK signalling and PEA3 expression also occurs in late-stage gastric adenocarcinomas. Furthermore, the co-association of ERK signalling and PEA3 expression correlates with decreased survival rates. Conclusions: This study shows that members of the PEA3 subfamily of transcription factors are upregulated in gastric adenocarcinomas and that the simultaneous upregulation of PEA3 expression and ERK pathway signalling is indicative of late-stage disease and a poor survival prognosis.
Item Type:
Article
Language:
en
ISSN:
0007-0920; 1532-1827

Full metadata record

DC FieldValue Language
dc.contributor.authorKeld, Ren_GB
dc.contributor.authorGuo, Ben_GB
dc.contributor.authorDowney, Pen_GB
dc.contributor.authorCummins, Ren_GB
dc.contributor.authorGulmann, Cen_GB
dc.contributor.authorAng, Y Sen_GB
dc.contributor.authorSharrocks, A Den_GB
dc.date.accessioned2012-06-25T16:08:51Z-
dc.date.available2012-06-25T16:08:51Z-
dc.date.issued2011-06-28-
dc.identifier.citationPEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma 2011, 105 (1):124 British Journal of Canceren_GB
dc.identifier.issn0007-0920-
dc.identifier.issn1532-1827-
dc.identifier.doi10.1038/bjc.2011.187-
dc.identifier.urihttp://hdl.handle.net/10147/230656-
dc.description.abstractBackground: Transcription factors often play important roles in tumourigenesis. Members of the PEA3 subfamily of ETS-domain transcription factors fulfil such a role and have been associated with tumour metastasis in several different cancers. Moreover, the activity of the PEA3 subfamily transcription factors is potentiated by Ras-ERK pathway signalling, which is itself often deregulated in tumour cells. Methods: Immunohistochemical patterns of PEA3 expression and active ERK signalling were analysed and mRNA expression levels of PEA3, ER81, MMP-1 and MMP-7 were determined in gastric adenocarcinoma samples. Results: Here, we have studied the expression of the PEA3 subfamily members PEA3/ETV4 and ER81/ETV1 in gastric adenocarcinomas. PEA3 is upregulated at the protein level in gastric adenocarcinomas and both PEA3/ETV4 and ER81/ETV1 are upregulated at the mRNA level in gastric adenocarcinoma tissues. This increased expression correlates with the expression of a target gene associated with metastasis, MMP-1. Enhanced ERK signalling is also more prevalent in late-stage gastric adenocarcinomas, and the co-association of ERK signalling and PEA3 expression also occurs in late-stage gastric adenocarcinomas. Furthermore, the co-association of ERK signalling and PEA3 expression correlates with decreased survival rates. Conclusions: This study shows that members of the PEA3 subfamily of transcription factors are upregulated in gastric adenocarcinomas and that the simultaneous upregulation of PEA3 expression and ERK pathway signalling is indicative of late-stage disease and a poor survival prognosis.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/bjc.2011.187en_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137405/pdf/bjc2011187a.pdfen_GB
dc.rightsArchived with thanks to British Journal of Canceren_GB
dc.titlePEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinomaen_GB
dc.typeArticleen
dc.identifier.journalBritish Journal of Canceren_GB
dc.description.provinceLeinsteren
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