Pharmacological modulation of arterial stiffness.

Hdl Handle:
http://hdl.handle.net/10147/230655
Title:
Pharmacological modulation of arterial stiffness.
Authors:
Boutouyrie, Pierre; Lacolley, Patrick; Briet, Marie; Regnault, Véronique; Stanton, Alice; Laurent, Stéphane; Mahmud, Azra
Affiliation:
HEGP, Assistance-publique Hpitaux de Paris, INSERM U970, Universit Paris Descartes, France. Pierre.boutouyrie@egp.aphp.fr
Citation:
Pharmacological modulation of arterial stiffness. 2011, 71 (13):1689-701 Drugs
Journal:
Drugs
Issue Date:
10-Sep-2011
URI:
http://hdl.handle.net/10147/230655
DOI:
10.2165/11593790-000000000-00000
PubMed ID:
21902292
Abstract:
Arterial stiffness has emerged as an important marker of cardiovascular risk in various populations and reflects the cumulative effect of cardiovascular risk factors on large arteries, which in turn is modulated by genetic background. Arterial stiffness is determined by the composition of the arterial wall and the arrangement of these components, and can be studied in humans non-invasively. Age and distending pressure are two major factors influencing large artery stiffness. Change in arterial stiffness with drugs is an important endpoint in clinical trials, although evidence for arterial stiffness as a therapeutic target still needs to be confirmed. Drugs that independently affect arterial stiffness include antihypertensive drugs, mostly blockers of the renin-angiotensin-aldosterone system, hormone replacement therapy and some antidiabetic drugs such as glitazones. While the quest continues for 'de-stiffening drugs', so far only advanced glycation endproduct cross-link breakers have shown promise.
Item Type:
Article
Language:
en
MeSH:
Animals; Antihypertensive Agents; Arteries; Humans; Vascular Diseases; Vascular Stiffness
ISSN:
0012-6667

Full metadata record

DC FieldValue Language
dc.contributor.authorBoutouyrie, Pierreen_GB
dc.contributor.authorLacolley, Patricken_GB
dc.contributor.authorBriet, Marieen_GB
dc.contributor.authorRegnault, Véroniqueen_GB
dc.contributor.authorStanton, Aliceen_GB
dc.contributor.authorLaurent, Stéphaneen_GB
dc.contributor.authorMahmud, Azraen_GB
dc.date.accessioned2012-06-25T16:07:09Z-
dc.date.available2012-06-25T16:07:09Z-
dc.date.issued2011-09-10-
dc.identifier.citationPharmacological modulation of arterial stiffness. 2011, 71 (13):1689-701 Drugsen_GB
dc.identifier.issn0012-6667-
dc.identifier.pmid21902292-
dc.identifier.doi10.2165/11593790-000000000-00000-
dc.identifier.urihttp://hdl.handle.net/10147/230655-
dc.description.abstractArterial stiffness has emerged as an important marker of cardiovascular risk in various populations and reflects the cumulative effect of cardiovascular risk factors on large arteries, which in turn is modulated by genetic background. Arterial stiffness is determined by the composition of the arterial wall and the arrangement of these components, and can be studied in humans non-invasively. Age and distending pressure are two major factors influencing large artery stiffness. Change in arterial stiffness with drugs is an important endpoint in clinical trials, although evidence for arterial stiffness as a therapeutic target still needs to be confirmed. Drugs that independently affect arterial stiffness include antihypertensive drugs, mostly blockers of the renin-angiotensin-aldosterone system, hormone replacement therapy and some antidiabetic drugs such as glitazones. While the quest continues for 'de-stiffening drugs', so far only advanced glycation endproduct cross-link breakers have shown promise.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Drugsen_GB
dc.subject.meshAnimals-
dc.subject.meshAntihypertensive Agents-
dc.subject.meshArteries-
dc.subject.meshHumans-
dc.subject.meshVascular Diseases-
dc.subject.meshVascular Stiffness-
dc.titlePharmacological modulation of arterial stiffness.en_GB
dc.typeArticleen
dc.contributor.departmentHEGP, Assistance-publique Hpitaux de Paris, INSERM U970, Universit Paris Descartes, France. Pierre.boutouyrie@egp.aphp.fren_GB
dc.identifier.journalDrugsen_GB
dc.description.provinceLeinsteren

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