HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
Authors
McCormack, MarkAlfirevic, Ana
Bourgeois, Stephane
Farrell, John J
Kasperavičiūtė, Dalia
Carrington, Mary
Sills, Graeme J
Marson, Tony
Jia, Xiaoming
de Bakker, Paul I W
Chinthapalli, Krishna
Molokhia, Mariam
Johnson, Michael R
O'Connor, Gerard D
Chaila, Elijah
Alhusaini, Saud
Shianna, Kevin V
Radtke, Rodney A
Heinzen, Erin L
Walley, Nicole
Pandolfo, Massimo
Pichler, Werner
Park, B Kevin
Depondt, Chantal
Sisodiya, Sanjay M
Goldstein, David B
Deloukas, Panos
Delanty, Norman
Cavalleri, Gianpiero L
Pirmohamed, Munir
Affiliation
Molecular and Cellular Therapeutics, the Royal College of Surgeons in Ireland, Dublin, Ireland.Issue Date
2011-03-24MeSH
AnticonvulsantsCarbamazepine
Drug Hypersensitivity
European Continental Ancestry Group
Exanthema
Genome-Wide Association Study
Genotype
HLA-A Antigens
Histocompatibility Testing
Humans
Polymorphism, Single Nucleotide
Stevens-Johnson Syndrome
Metadata
Show full item recordCitation
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. 2011, 364 (12):1134-43 N. Engl. J. Med.Journal
The New England journal of medicineDOI
10.1056/NEJMoa1013297PubMed ID
21428769Abstract
Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.Item Type
ArticleLanguage
enISSN
1533-4406ae974a485f413a2113503eed53cd6c53
10.1056/NEJMoa1013297
Scopus Count
Collections
Related articles
- Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations.
- Authors: Hsiao YH, Hui RC, Wu T, Chang WC, Hsih MS, Yang CH, Ho HC, Chang YG, Chen MJ, Lin JY, Chen DP, Chang PY, Wu TL, Hung SI, Chung WH
- Issue date: 2014 Feb
- Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
- Authors: Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT
- Issue date: 2006 Apr
- Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients.
- Authors: Sukasem C, Chaichan C, Nakkrut T, Satapornpong P, Jaruthamsophon K, Jantararoungtong T, Koomdee N, Sririttha S, Medhasi S, Oo-Puthinan S, Rerkpattanapipat T, Klaewsongkram J, Rerknimitr P, Tuchinda P, Chularojanamontri L, Tovanabutra N, Puangpetch A, Aekplakorn W
- Issue date: 2018
- Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.
- Authors: Amstutz U, Shear NH, Rieder MJ, Hwang S, Fung V, Nakamura H, Connolly MB, Ito S, Carleton BC, CPNDS clinical recommendation group
- Issue date: 2014 Apr
- HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis.
- Authors: Grover S, Kukreti R
- Issue date: 2014 Feb