HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

Hdl Handle:
http://hdl.handle.net/10147/229952
Title:
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
Authors:
McCormack, Mark; Alfirevic, Ana; Bourgeois, Stephane; Farrell, John J; Kasperavičiūtė, Dalia; Carrington, Mary; Sills, Graeme J; Marson, Tony; Jia, Xiaoming; de Bakker, Paul I W; Chinthapalli, Krishna; Molokhia, Mariam; Johnson, Michael R; O'Connor, Gerard D; Chaila, Elijah; Alhusaini, Saud; Shianna, Kevin V; Radtke, Rodney A; Heinzen, Erin L; Walley, Nicole; Pandolfo, Massimo; Pichler, Werner; Park, B Kevin; Depondt, Chantal; Sisodiya, Sanjay M; Goldstein, David B; Deloukas, Panos; Delanty, Norman; Cavalleri, Gianpiero L; Pirmohamed, Munir
Affiliation:
Molecular and Cellular Therapeutics, the Royal College of Surgeons in Ireland, Dublin, Ireland.
Citation:
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. 2011, 364 (12):1134-43 N. Engl. J. Med.
Journal:
The New England journal of medicine
Issue Date:
24-Mar-2011
URI:
http://hdl.handle.net/10147/229952
DOI:
10.1056/NEJMoa1013297
PubMed ID:
21428769
Abstract:
Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.
Item Type:
Article
Language:
en
MeSH:
Anticonvulsants; Carbamazepine; Drug Hypersensitivity; European Continental Ancestry Group; Exanthema; Genome-Wide Association Study; Genotype; HLA-A Antigens; Histocompatibility Testing; Humans; Polymorphism, Single Nucleotide; Stevens-Johnson Syndrome
ISSN:
1533-4406

Full metadata record

DC FieldValue Language
dc.contributor.authorMcCormack, Marken_GB
dc.contributor.authorAlfirevic, Anaen_GB
dc.contributor.authorBourgeois, Stephaneen_GB
dc.contributor.authorFarrell, John Jen_GB
dc.contributor.authorKasperavičiūtė, Daliaen_GB
dc.contributor.authorCarrington, Maryen_GB
dc.contributor.authorSills, Graeme Jen_GB
dc.contributor.authorMarson, Tonyen_GB
dc.contributor.authorJia, Xiaomingen_GB
dc.contributor.authorde Bakker, Paul I Wen_GB
dc.contributor.authorChinthapalli, Krishnaen_GB
dc.contributor.authorMolokhia, Mariamen_GB
dc.contributor.authorJohnson, Michael Ren_GB
dc.contributor.authorO'Connor, Gerard Den_GB
dc.contributor.authorChaila, Elijahen_GB
dc.contributor.authorAlhusaini, Sauden_GB
dc.contributor.authorShianna, Kevin Ven_GB
dc.contributor.authorRadtke, Rodney Aen_GB
dc.contributor.authorHeinzen, Erin Len_GB
dc.contributor.authorWalley, Nicoleen_GB
dc.contributor.authorPandolfo, Massimoen_GB
dc.contributor.authorPichler, Werneren_GB
dc.contributor.authorPark, B Kevinen_GB
dc.contributor.authorDepondt, Chantalen_GB
dc.contributor.authorSisodiya, Sanjay Men_GB
dc.contributor.authorGoldstein, David Ben_GB
dc.contributor.authorDeloukas, Panosen_GB
dc.contributor.authorDelanty, Normanen_GB
dc.contributor.authorCavalleri, Gianpiero Len_GB
dc.contributor.authorPirmohamed, Muniren_GB
dc.date.accessioned2012-06-20T14:18:07Z-
dc.date.available2012-06-20T14:18:07Z-
dc.date.issued2011-03-24-
dc.identifier.citationHLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. 2011, 364 (12):1134-43 N. Engl. J. Med.en_GB
dc.identifier.issn1533-4406-
dc.identifier.pmid21428769-
dc.identifier.doi10.1056/NEJMoa1013297-
dc.identifier.urihttp://hdl.handle.net/10147/229952-
dc.description.abstractCarbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to The New England journal of medicineen_GB
dc.subject.meshAnticonvulsants-
dc.subject.meshCarbamazepine-
dc.subject.meshDrug Hypersensitivity-
dc.subject.meshEuropean Continental Ancestry Group-
dc.subject.meshExanthema-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshGenotype-
dc.subject.meshHLA-A Antigens-
dc.subject.meshHistocompatibility Testing-
dc.subject.meshHumans-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshStevens-Johnson Syndrome-
dc.titleHLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.en_GB
dc.typeArticleen
dc.contributor.departmentMolecular and Cellular Therapeutics, the Royal College of Surgeons in Ireland, Dublin, Ireland.en_GB
dc.identifier.journalThe New England journal of medicineen_GB
dc.description.provinceLeinsteren

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