COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome.

Hdl Handle:
http://hdl.handle.net/10147/229140
Title:
COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome.
Authors:
Boot, Erik; Booij, Jan; Zinkstok, Janneke R; Baas, Frank; Swillen, Ann; Owen, Michael J; Murphy, Declan G; Murphy, Kieran C; Linszen, Don H; Van Amelsvoort, Thérèse A
Affiliation:
Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. h.j.boot@amc.uva.nl
Citation:
COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome. 2011, 65 (9):967-70 Synapse
Journal:
Synapse (New York, N.Y.)
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10147/229140
DOI:
10.1002/syn.20932
PubMed ID:
21465565
Abstract:
Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.
Item Type:
Article
Language:
en
MeSH:
22q11 Deletion Syndrome; Adolescent; Adult; Catechol O-Methyltransferase; Corpus Striatum; Female; Genotype; Humans; Male; Methionine; Protein Binding; Receptors, Dopamine D2; Receptors, Dopamine D3; Tomography, Emission-Computed, Single-Photon; Valine; Young Adult
ISSN:
1098-2396

Full metadata record

DC FieldValue Language
dc.contributor.authorBoot, Eriken_GB
dc.contributor.authorBooij, Janen_GB
dc.contributor.authorZinkstok, Janneke Ren_GB
dc.contributor.authorBaas, Franken_GB
dc.contributor.authorSwillen, Annen_GB
dc.contributor.authorOwen, Michael Jen_GB
dc.contributor.authorMurphy, Declan Gen_GB
dc.contributor.authorMurphy, Kieran Cen_GB
dc.contributor.authorLinszen, Don Hen_GB
dc.contributor.authorVan Amelsvoort, Thérèse Aen_GB
dc.date.accessioned2012-06-15T13:44:59Z-
dc.date.available2012-06-15T13:44:59Z-
dc.date.issued2011-09-
dc.identifier.citationCOMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome. 2011, 65 (9):967-70 Synapseen_GB
dc.identifier.issn1098-2396-
dc.identifier.pmid21465565-
dc.identifier.doi10.1002/syn.20932-
dc.identifier.urihttp://hdl.handle.net/10147/229140-
dc.description.abstractAlthough catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Synapse (New York, N.Y.)en_GB
dc.subject.mesh22q11 Deletion Syndrome-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshCatechol O-Methyltransferase-
dc.subject.meshCorpus Striatum-
dc.subject.meshFemale-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMethionine-
dc.subject.meshProtein Binding-
dc.subject.meshReceptors, Dopamine D2-
dc.subject.meshReceptors, Dopamine D3-
dc.subject.meshTomography, Emission-Computed, Single-Photon-
dc.subject.meshValine-
dc.subject.meshYoung Adult-
dc.titleCOMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. h.j.boot@amc.uva.nlen_GB
dc.identifier.journalSynapse (New York, N.Y.)en_GB
dc.description.provinceLeinsteren

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