Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent.

Hdl Handle:
http://hdl.handle.net/10147/229094
Title:
Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent.
Authors:
Bergin, David A; Hurley, Killian; McElvaney, Noel G; Reeves, Emer P
Affiliation:
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Citation:
Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent. 2012, 60 (2):81-97 Arch. Immunol. Ther. Exp. (Warsz.)
Journal:
Archivum immunologiae et therapiae experimentalis
Issue Date:
Apr-2012
URI:
http://hdl.handle.net/10147/229094
DOI:
10.1007/s00005-012-0162-5
PubMed ID:
22349104
Abstract:
Alpha-1 antitrypsin (AAT) has long been thought of as an important anti-protease in the lung where it is known to decrease the destructive effects of major proteases such as neutrophil elastase. In recent years, the perception of this protein in this simple one dimensional capacity as an anti-protease has evolved and it is now recognised that AAT has significant anti-inflammatory properties affecting a wide range of inflammatory cells, leading to its potential therapeutic use in a number of important diseases. This present review aims to discuss the described anti-inflammatory actions of AAT in modulating key immune cell functions, delineate known signalling pathways and specifically to identify the models of disease in which AAT has been shown to be effective as a therapy.
Item Type:
Article
Language:
en
ISSN:
1661-4917

Full metadata record

DC FieldValue Language
dc.contributor.authorBergin, David Aen_GB
dc.contributor.authorHurley, Killianen_GB
dc.contributor.authorMcElvaney, Noel Gen_GB
dc.contributor.authorReeves, Emer Pen_GB
dc.date.accessioned2012-06-15T11:53:09Z-
dc.date.available2012-06-15T11:53:09Z-
dc.date.issued2012-04-
dc.identifier.citationAlpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent. 2012, 60 (2):81-97 Arch. Immunol. Ther. Exp. (Warsz.)en_GB
dc.identifier.issn1661-4917-
dc.identifier.pmid22349104-
dc.identifier.doi10.1007/s00005-012-0162-5-
dc.identifier.urihttp://hdl.handle.net/10147/229094-
dc.description.abstractAlpha-1 antitrypsin (AAT) has long been thought of as an important anti-protease in the lung where it is known to decrease the destructive effects of major proteases such as neutrophil elastase. In recent years, the perception of this protein in this simple one dimensional capacity as an anti-protease has evolved and it is now recognised that AAT has significant anti-inflammatory properties affecting a wide range of inflammatory cells, leading to its potential therapeutic use in a number of important diseases. This present review aims to discuss the described anti-inflammatory actions of AAT in modulating key immune cell functions, delineate known signalling pathways and specifically to identify the models of disease in which AAT has been shown to be effective as a therapy.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Archivum immunologiae et therapiae experimentalisen_GB
dc.titleAlpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent.en_GB
dc.typeArticleen
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.en_GB
dc.identifier.journalArchivum immunologiae et therapiae experimentalisen_GB
dc.description.provinceLeinsteren

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