A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.

Hdl Handle:
http://hdl.handle.net/10147/229081
Title:
A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.
Authors:
Ramsey, Bonnie W; Davies, Jane; McElvaney, N Gerard; Tullis, Elizabeth; Bell, Scott C; Dřevínek, Pavel; Griese, Matthias; McKone, Edward F; Wainwright, Claire E; Konstan, Michael W; Moss, Richard; Ratjen, Felix; Sermet-Gaudelus, Isabelle; Rowe, Steven M; Dong, Qunming; Rodriguez, Sally; Yen, Karl; Ordoñez, Claudia; Elborn, J Stuart
Affiliation:
Seattle Children's Hospital and University of Washington School of Medicine, Seattle WA 98105-0371, USA. bonnie.ramsey@seattlechildrens.org
Citation:
A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. 2011, 365 (18):1663-72 N. Engl. J. Med.
Journal:
The New England journal of medicine
Issue Date:
3-Nov-2011
URI:
http://hdl.handle.net/10147/229081
DOI:
10.1056/NEJMoa1105185
PubMed ID:
22047557
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230303/pdf/nihms338788.pdf; http://www.nejm.org/doi/pdf/10.1056/NEJMoa1105185
Abstract:
Increasing the activity of defective cystic fibrosis transmembrane conductance regulator (CFTR) protein is a potential treatment for cystic fibrosis.
Item Type:
Article
Language:
en
MeSH:
Administration, Oral; Adolescent; Adult; Aminophenols; Child; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Synergism; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Mutation; Quinolones; Young Adult
ISSN:
1533-4406

Full metadata record

DC FieldValue Language
dc.contributor.authorRamsey, Bonnie Wen_GB
dc.contributor.authorDavies, Janeen_GB
dc.contributor.authorMcElvaney, N Gerarden_GB
dc.contributor.authorTullis, Elizabethen_GB
dc.contributor.authorBell, Scott Cen_GB
dc.contributor.authorDřevínek, Pavelen_GB
dc.contributor.authorGriese, Matthiasen_GB
dc.contributor.authorMcKone, Edward Fen_GB
dc.contributor.authorWainwright, Claire Een_GB
dc.contributor.authorKonstan, Michael Wen_GB
dc.contributor.authorMoss, Richarden_GB
dc.contributor.authorRatjen, Felixen_GB
dc.contributor.authorSermet-Gaudelus, Isabelleen_GB
dc.contributor.authorRowe, Steven Men_GB
dc.contributor.authorDong, Qunmingen_GB
dc.contributor.authorRodriguez, Sallyen_GB
dc.contributor.authorYen, Karlen_GB
dc.contributor.authorOrdoñez, Claudiaen_GB
dc.contributor.authorElborn, J Stuarten_GB
dc.date.accessioned2012-06-15T10:14:40Z-
dc.date.available2012-06-15T10:14:40Z-
dc.date.issued2011-11-03-
dc.identifier.citationA CFTR potentiator in patients with cystic fibrosis and the G551D mutation. 2011, 365 (18):1663-72 N. Engl. J. Med.en_GB
dc.identifier.issn1533-4406-
dc.identifier.pmid22047557-
dc.identifier.doi10.1056/NEJMoa1105185-
dc.identifier.urihttp://hdl.handle.net/10147/229081-
dc.description.abstractIncreasing the activity of defective cystic fibrosis transmembrane conductance regulator (CFTR) protein is a potential treatment for cystic fibrosis.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230303/pdf/nihms338788.pdfen_GB
dc.relation.urlhttp://www.nejm.org/doi/pdf/10.1056/NEJMoa1105185en_GB
dc.rightsArchived with thanks to The New England journal of medicineen_GB
dc.subject.meshAdministration, Oral-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAminophenols-
dc.subject.meshChild-
dc.subject.meshCystic Fibrosis-
dc.subject.meshCystic Fibrosis Transmembrane Conductance Regulator-
dc.subject.meshDrug Synergism-
dc.subject.meshFemale-
dc.subject.meshForced Expiratory Volume-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMutation-
dc.subject.meshQuinolones-
dc.subject.meshYoung Adult-
dc.titleA CFTR potentiator in patients with cystic fibrosis and the G551D mutation.en_GB
dc.typeArticleen
dc.contributor.departmentSeattle Children's Hospital and University of Washington School of Medicine, Seattle WA 98105-0371, USA. bonnie.ramsey@seattlechildrens.orgen_GB
dc.identifier.journalThe New England journal of medicineen_GB
dc.description.provinceLeinsteren

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