14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.

Hdl Handle:
http://hdl.handle.net/10147/229038
Title:
14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.
Authors:
Ravi, Dashnamoorthy; Chen, Yidong; Karia, Bijal; Brown, Adam; Gu, Ting Ting; Li, Jie; Carey, Mark S; Hennessy, Bryan T; Bishop, Alexander J R
Affiliation:
Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America.
Citation:
14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. 2011, 6 (1):e15864 PLoS ONE
Journal:
PloS one
Issue Date:
2011
URI:
http://hdl.handle.net/10147/229038
DOI:
10.1371/journal.pone.0015864
PubMed ID:
21249227
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018427/pdf/pone.0015864.pdf
Abstract:
In vitro cell culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O₂ levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O₂ may be undesirable. To understand better the impact of O₂ on the propagation of cancer cells in vitro, we compared the growth potential of a panel of ovarian cancer cell lines under ambient (21%) or physiological (3%) O₂.
Item Type:
Article
Language:
en
MeSH:
14-3-3 Proteins; Cell Division; Cell Proliferation; Dose-Response Relationship, Drug; Female; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Ovarian Neoplasms; Oxygen; Tumor Cells, Cultured
ISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorRavi, Dashnamoorthyen_GB
dc.contributor.authorChen, Yidongen_GB
dc.contributor.authorKaria, Bijalen_GB
dc.contributor.authorBrown, Adamen_GB
dc.contributor.authorGu, Ting Tingen_GB
dc.contributor.authorLi, Jieen_GB
dc.contributor.authorCarey, Mark Sen_GB
dc.contributor.authorHennessy, Bryan Ten_GB
dc.contributor.authorBishop, Alexander J Ren_GB
dc.date.accessioned2012-06-15T10:13:37Z-
dc.date.available2012-06-15T10:13:37Z-
dc.date.issued2011-
dc.identifier.citation14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. 2011, 6 (1):e15864 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid21249227-
dc.identifier.doi10.1371/journal.pone.0015864-
dc.identifier.urihttp://hdl.handle.net/10147/229038-
dc.description.abstractIn vitro cell culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O₂ levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O₂ may be undesirable. To understand better the impact of O₂ on the propagation of cancer cells in vitro, we compared the growth potential of a panel of ovarian cancer cell lines under ambient (21%) or physiological (3%) O₂.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018427/pdf/pone.0015864.pdfen_GB
dc.rightsArchived with thanks to PloS oneen_GB
dc.subject.mesh14-3-3 Proteins-
dc.subject.meshCell Division-
dc.subject.meshCell Proliferation-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshFemale-
dc.subject.meshG2 Phase-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshHumans-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshOxygen-
dc.subject.meshTumor Cells, Cultured-
dc.title14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.en_GB
dc.typeArticleen
dc.contributor.departmentGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America.en_GB
dc.identifier.journalPloS oneen_GB
dc.description.provinceLeinsteren

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