Review article: loss of the calcium-sensing receptor in colonic epithelium is a key event in the pathogenesis of colon cancer.

Hdl Handle:
http://hdl.handle.net/10147/228071
Title:
Review article: loss of the calcium-sensing receptor in colonic epithelium is a key event in the pathogenesis of colon cancer.
Authors:
Rogers, Ailín C; Hanly, Ann M; Collins, Danielle; Baird, Alan W; Winter, Desmond C
Affiliation:
Institute for Clinical Outcomes, Research and Education (iCORE), St. Vincents University Hospital, Dublin, Ireland. ailinrogers@gmail.com
Citation:
Review article: loss of the calcium-sensing receptor in colonic epithelium is a key event in the pathogenesis of colon cancer. 2012, 11 (1):24-30 Clin Colorectal Cancer
Journal:
Clinical colorectal cancer
Issue Date:
Mar-2012
URI:
http://hdl.handle.net/10147/228071
DOI:
10.1016/j.clcc.2011.04.003
PubMed ID:
21723793
Abstract:
The calcium-sensing receptor (CaSR) is expressed abundantly in normal colonic epithelium and lost in colon cancer, but its exact role on a molecular level and within the carcinogenesis pathway is yet to be described. Epidemiologic studies show that inadequate dietary calcium predisposes to colon cancer; this may be due to the ability of calcium to bind and upregulate the CaSR. Loss of CaSR expression does not seem to be an early event in carcinogenesis; indeed it is associated with late stage, poorly differentiated, chemo-resistant tumors. Induction of CaSR expression in neoplastic colonocytes arrests tumor progression and deems tumors more sensitive to chemotherapy; hence CaSR may be an important target in colon cancer treatment. The CaSR has a complex role in colon cancer; however, more investigation is required on a molecular level to clarify its exact function in carcinogenesis. This review describes the mechanisms by which the CaSR is currently implicated in colon cancer and identifies areas where further study is needed.
Item Type:
Article
Language:
en
MeSH:
Colonic Neoplasms; Disease Progression; Humans; Receptors, Calcium-Sensing
ISSN:
1938-0674

Full metadata record

DC FieldValue Language
dc.contributor.authorRogers, Ailín Cen_GB
dc.contributor.authorHanly, Ann Men_GB
dc.contributor.authorCollins, Danielleen_GB
dc.contributor.authorBaird, Alan Wen_GB
dc.contributor.authorWinter, Desmond Cen_GB
dc.date.accessioned2012-06-08T14:53:41Z-
dc.date.available2012-06-08T14:53:41Z-
dc.date.issued2012-03-
dc.identifier.citationReview article: loss of the calcium-sensing receptor in colonic epithelium is a key event in the pathogenesis of colon cancer. 2012, 11 (1):24-30 Clin Colorectal Canceren_GB
dc.identifier.issn1938-0674-
dc.identifier.pmid21723793-
dc.identifier.doi10.1016/j.clcc.2011.04.003-
dc.identifier.urihttp://hdl.handle.net/10147/228071-
dc.description.abstractThe calcium-sensing receptor (CaSR) is expressed abundantly in normal colonic epithelium and lost in colon cancer, but its exact role on a molecular level and within the carcinogenesis pathway is yet to be described. Epidemiologic studies show that inadequate dietary calcium predisposes to colon cancer; this may be due to the ability of calcium to bind and upregulate the CaSR. Loss of CaSR expression does not seem to be an early event in carcinogenesis; indeed it is associated with late stage, poorly differentiated, chemo-resistant tumors. Induction of CaSR expression in neoplastic colonocytes arrests tumor progression and deems tumors more sensitive to chemotherapy; hence CaSR may be an important target in colon cancer treatment. The CaSR has a complex role in colon cancer; however, more investigation is required on a molecular level to clarify its exact function in carcinogenesis. This review describes the mechanisms by which the CaSR is currently implicated in colon cancer and identifies areas where further study is needed.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Clinical colorectal canceren_GB
dc.subject.meshColonic Neoplasms-
dc.subject.meshDisease Progression-
dc.subject.meshHumans-
dc.subject.meshReceptors, Calcium-Sensing-
dc.titleReview article: loss of the calcium-sensing receptor in colonic epithelium is a key event in the pathogenesis of colon cancer.en_GB
dc.typeArticleen
dc.contributor.departmentInstitute for Clinical Outcomes, Research and Education (iCORE), St. Vincents University Hospital, Dublin, Ireland. ailinrogers@gmail.comen_GB
dc.identifier.journalClinical colorectal canceren_GB
dc.description.provinceLeinsteren

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