Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.

Hdl Handle:
http://hdl.handle.net/10147/223835
Title:
Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.
Authors:
Walsh, Ceara E; Ryan, Elizabeth J; O'Farrelly, Cliona; Golden-Mason, Lucy; FitzGerald, Oliver; Veale, Douglas J; Bresnihan, Barry; Fearon, Ursula
Affiliation:
Translation Rheumatology Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin, Ireland. cearaesmondewalsh@physicians.ie
Citation:
Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease. 2011, 6 (11):e27182 PLoS ONE
Journal:
PloS one
Issue Date:
2011
URI:
http://hdl.handle.net/10147/223835
DOI:
10.1371/journal.pone.0027182
PubMed ID:
22102879
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216944/?tool=pubmed
Abstract:
TNF inhibitors (TNFi) have revolutionised the treatment of rheumatoid arthritis (RA). Natural killer (NK) cells and Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose activity is tightly regulated through surface NK receptors (NKRs). Dysregulation of NKRs in patients with autoimmune diseases has been shown, however little is known regarding NKRs expression in patients with TNFi-induced remission and in those who maintain remission vs disease flare following TNFi withdrawal.
Item Type:
Article
Language:
en
MeSH:
Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Remission Induction; T-Lymphocytes; Tumor Necrosis Factor-alpha
ISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorWalsh, Ceara Een_GB
dc.contributor.authorRyan, Elizabeth Jen_GB
dc.contributor.authorO'Farrelly, Clionaen_GB
dc.contributor.authorGolden-Mason, Lucyen_GB
dc.contributor.authorFitzGerald, Oliveren_GB
dc.contributor.authorVeale, Douglas Jen_GB
dc.contributor.authorBresnihan, Barryen_GB
dc.contributor.authorFearon, Ursulaen_GB
dc.date.accessioned2012-05-15T15:03:17Z-
dc.date.available2012-05-15T15:03:17Z-
dc.date.issued2011-
dc.identifier.citationDifferential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease. 2011, 6 (11):e27182 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid22102879-
dc.identifier.doi10.1371/journal.pone.0027182-
dc.identifier.urihttp://hdl.handle.net/10147/223835-
dc.description.abstractTNF inhibitors (TNFi) have revolutionised the treatment of rheumatoid arthritis (RA). Natural killer (NK) cells and Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose activity is tightly regulated through surface NK receptors (NKRs). Dysregulation of NKRs in patients with autoimmune diseases has been shown, however little is known regarding NKRs expression in patients with TNFi-induced remission and in those who maintain remission vs disease flare following TNFi withdrawal.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216944/?tool=pubmeden_GB
dc.rightsArchived with thanks to PloS oneen_GB
dc.subject.meshArthritis, Rheumatoid-
dc.subject.meshCase-Control Studies-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshKiller Cells, Natural-
dc.subject.meshLeukocytes, Mononuclear-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNK Cell Lectin-Like Receptor Subfamily C-
dc.subject.meshNK Cell Lectin-Like Receptor Subfamily D-
dc.subject.meshRemission Induction-
dc.subject.meshT-Lymphocytes-
dc.subject.meshTumor Necrosis Factor-alpha-
dc.titleDifferential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.en_GB
dc.typeArticleen
dc.contributor.departmentTranslation Rheumatology Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin, Ireland. cearaesmondewalsh@physicians.ieen_GB
dc.identifier.journalPloS oneen_GB
dc.description.provinceLeinsteren

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