Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)

Hdl Handle:
http://hdl.handle.net/10147/223255
Title:
Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)
Authors:
Stamuli, Eugena; Cockayne, Sarah; Hewitt, Catherine; Hicks, Kate; Jayakody, Shalmini; Ricky Kang'ombe, Arthur; Turner, Gwen; Thomas, Kim; Curran, Mike; Hashmi, Farina; McIntosh, Caroline; McLarnon, Nichola; Torgerson, David J; Watt, Ian
Citation:
Journal of Foot and Ankle Research. 2012 Feb 27;5(1):4
Issue Date:
27-Feb-2012
URI:
http://dx.doi.org/10.1186/1757-1146-5-4; http://hdl.handle.net/10147/223255
Abstract:
Abstract Background Plantar warts (verrucae) are extremely common. Although many will spontaneously disappear without treatment, treatment may be sought for a variety of reasons such as discomfort. There are a number of different treatments for cutaneous warts, with salicylic acid and cryotherapy using liquid nitrogen being two of the most common forms of treatment. To date, no full economic evaluation of either salicylic acid or cryotherapy has been conducted based on the use of primary data in a pragmatic setting. This paper describes the cost-effectiveness analysis which was conducted alongside a pragmatic multicentre, randomised trial evaluating the clinical effectiveness of cryotherapy versus 50% salicylic acid of the treatment of plantar warts. Methods A cost-effectiveness analysis was undertaken alongside a pragmatic multicentre, randomised controlled trial assessing the clinical effectiveness of 50% salicylic acid and cryotherapy using liquid nitrogen at 12 weeks after randomisation of patients. Cost-effectiveness outcomes were expressed as the additional cost required to completely cure the plantar warts of one additional patient. A NHS perspective was taken for the analysis. Results Cryotherapy costs on average £101.17 (bias corrected and accelerated (BCA) 95% CI: 85.09-117.26) more per participant over the 12 week time-frame, while there is no additional benefit, in terms of proportion of patients healed compared with salicylic acid. Conclusions Cryotherapy is more costly and no more effective than salicylic acid. Trial registration Current Controlled Trials ISRCTN18994246 [controlled-trials.com] and National Research Register N0484189151.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorStamuli, Eugena-
dc.contributor.authorCockayne, Sarah-
dc.contributor.authorHewitt, Catherine-
dc.contributor.authorHicks, Kate-
dc.contributor.authorJayakody, Shalmini-
dc.contributor.authorRicky Kang'ombe, Arthur-
dc.contributor.authorTurner, Gwen-
dc.contributor.authorThomas, Kim-
dc.contributor.authorCurran, Mike-
dc.contributor.authorHashmi, Farina-
dc.contributor.authorMcIntosh, Caroline-
dc.contributor.authorMcLarnon, Nichola-
dc.contributor.authorTorgerson, David J-
dc.contributor.authorWatt, Ian-
dc.date.accessioned2012-05-11T13:15:16Z-
dc.date.available2012-05-11T13:15:16Z-
dc.date.issued2012-02-27-
dc.identifier.citationJournal of Foot and Ankle Research. 2012 Feb 27;5(1):4-
dc.identifier.urihttp://dx.doi.org/10.1186/1757-1146-5-4-
dc.identifier.urihttp://hdl.handle.net/10147/223255-
dc.description.abstractAbstract Background Plantar warts (verrucae) are extremely common. Although many will spontaneously disappear without treatment, treatment may be sought for a variety of reasons such as discomfort. There are a number of different treatments for cutaneous warts, with salicylic acid and cryotherapy using liquid nitrogen being two of the most common forms of treatment. To date, no full economic evaluation of either salicylic acid or cryotherapy has been conducted based on the use of primary data in a pragmatic setting. This paper describes the cost-effectiveness analysis which was conducted alongside a pragmatic multicentre, randomised trial evaluating the clinical effectiveness of cryotherapy versus 50% salicylic acid of the treatment of plantar warts. Methods A cost-effectiveness analysis was undertaken alongside a pragmatic multicentre, randomised controlled trial assessing the clinical effectiveness of 50% salicylic acid and cryotherapy using liquid nitrogen at 12 weeks after randomisation of patients. Cost-effectiveness outcomes were expressed as the additional cost required to completely cure the plantar warts of one additional patient. A NHS perspective was taken for the analysis. Results Cryotherapy costs on average £101.17 (bias corrected and accelerated (BCA) 95% CI: 85.09-117.26) more per participant over the 12 week time-frame, while there is no additional benefit, in terms of proportion of patients healed compared with salicylic acid. Conclusions Cryotherapy is more costly and no more effective than salicylic acid. Trial registration Current Controlled Trials ISRCTN18994246 [controlled-trials.com] and National Research Register N0484189151.-
dc.titleCost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderStamuli et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2012-05-08T15:09:39Z-
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