Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells.

Hdl Handle:
http://hdl.handle.net/10147/222694
Title:
Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells.
Authors:
Duncan, Henry F; Smith, Anthony J; Fleming, Garry J P; Cooper, Paul R
Affiliation:
Division of Restorative Dentistry and Periodontology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland. Hal.Duncan@dental.tcd.ie
Citation:
Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. 2012, 38 (3):339-45 J Endod
Journal:
Journal of endodontics
Issue Date:
Mar-2012
URI:
http://hdl.handle.net/10147/222694
DOI:
10.1016/j.joen.2011.12.014
PubMed ID:
22341071
Abstract:
Histone deacetylase inhibitors (HDACis) alter the homeostatic balance between 2 groups of cellular enzymes, histone deacetylases (HDACs) and histone acetyltransferases (HATs), increasing transcription and influencing cell behavior. This study investigated the potential of 2 HDACis, valproic acid (VPA) and trichostatin A (TSA), to promote reparative processes in pulp cells as assayed by viability, cell cycle, and mineralization analyses.
Item Type:
Article
Language:
en
ISSN:
1878-3554

Full metadata record

DC FieldValue Language
dc.contributor.authorDuncan, Henry Fen_GB
dc.contributor.authorSmith, Anthony Jen_GB
dc.contributor.authorFleming, Garry J Pen_GB
dc.contributor.authorCooper, Paul Ren_GB
dc.date.accessioned2012-05-09T09:41:54Z-
dc.date.available2012-05-09T09:41:54Z-
dc.date.issued2012-03-
dc.identifier.citationHistone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. 2012, 38 (3):339-45 J Endoden_GB
dc.identifier.issn1878-3554-
dc.identifier.pmid22341071-
dc.identifier.doi10.1016/j.joen.2011.12.014-
dc.identifier.urihttp://hdl.handle.net/10147/222694-
dc.description.abstractHistone deacetylase inhibitors (HDACis) alter the homeostatic balance between 2 groups of cellular enzymes, histone deacetylases (HDACs) and histone acetyltransferases (HATs), increasing transcription and influencing cell behavior. This study investigated the potential of 2 HDACis, valproic acid (VPA) and trichostatin A (TSA), to promote reparative processes in pulp cells as assayed by viability, cell cycle, and mineralization analyses.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Journal of endodonticsen_GB
dc.titleHistone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells.en_GB
dc.typeArticleen
dc.contributor.departmentDivision of Restorative Dentistry and Periodontology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland. Hal.Duncan@dental.tcd.ieen_GB
dc.identifier.journalJournal of endodonticsen_GB
dc.description.provinceLeinsteren

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