Differential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?

Hdl Handle:
http://hdl.handle.net/10147/221977
Title:
Differential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?
Authors:
Sullivan, Derek J; Moran, Gary P
Affiliation:
Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, University of Dublin, Ireland.
Citation:
Differential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?, 2 (1):77-81 Virulence
Journal:
Virulence
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/221977
PubMed ID:
21289475
Abstract:
Candida albicans and Candida dubliniensis are two very closely related species of pathogenic yeast. C. albicans is the most prevalent species in the human gastrointestinal tract and is responsible for far more opportunistic infections in comparison with C. dubliniensis. This disparity is likely to be due to the reduced ability of C. dubliniensis to undergo the yeast to hypha transition, a change in morphology that plays an important role in C. albicans virulence. We have recently shown that hypha formation by C. dubliniensis is specifically repressed by nutrients at alkaline pH. In this article, we present new data showing that this can be partly reversed by treatment with rapamycin, an inhibitor of the nutrient sensing kinase Tor1 (Target Of Rapamycin). We also provide a speculative model to describe why C. albicans filaments more efficiently in nutrient rich environments, citing recently described data on Mds3, a pH responsive regulator of Tor1 kinase activity.
Item Type:
Article
Language:
en
MeSH:
Candida; Candida albicans; Candidiasis; Fungal Proteins; Humans; TOR Serine-Threonine Kinases; Virulence
ISSN:
2150-5608

Full metadata record

DC FieldValue Language
dc.contributor.authorSullivan, Derek Jen_GB
dc.contributor.authorMoran, Gary Pen_GB
dc.date.accessioned2012-05-04T11:22:36Z-
dc.date.available2012-05-04T11:22:36Z-
dc.date.issued2011-01-
dc.identifier.citationDifferential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?, 2 (1):77-81 Virulenceen_GB
dc.identifier.issn2150-5608-
dc.identifier.pmid21289475-
dc.identifier.urihttp://hdl.handle.net/10147/221977-
dc.description.abstractCandida albicans and Candida dubliniensis are two very closely related species of pathogenic yeast. C. albicans is the most prevalent species in the human gastrointestinal tract and is responsible for far more opportunistic infections in comparison with C. dubliniensis. This disparity is likely to be due to the reduced ability of C. dubliniensis to undergo the yeast to hypha transition, a change in morphology that plays an important role in C. albicans virulence. We have recently shown that hypha formation by C. dubliniensis is specifically repressed by nutrients at alkaline pH. In this article, we present new data showing that this can be partly reversed by treatment with rapamycin, an inhibitor of the nutrient sensing kinase Tor1 (Target Of Rapamycin). We also provide a speculative model to describe why C. albicans filaments more efficiently in nutrient rich environments, citing recently described data on Mds3, a pH responsive regulator of Tor1 kinase activity.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Virulenceen_GB
dc.subject.meshCandida-
dc.subject.meshCandida albicans-
dc.subject.meshCandidiasis-
dc.subject.meshFungal Proteins-
dc.subject.meshHumans-
dc.subject.meshTOR Serine-Threonine Kinases-
dc.subject.meshVirulence-
dc.titleDifferential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?en_GB
dc.typeArticleen
dc.contributor.departmentMicrobiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, University of Dublin, Ireland.en_GB
dc.identifier.journalVirulenceen_GB
dc.description.provinceLeinsteren

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