The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension.

Hdl Handle:
http://hdl.handle.net/10147/221960
Title:
The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension.
Authors:
Martin, Ronny; Moran, Gary P; Jacobsen, Ilse D; Heyken, Antje; Domey, Jenny; Sullivan, Derek J; Kurzai, Oliver; Hube, Bernhard
Affiliation:
Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Citation:
The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. 2011, 6 (4):e18394 PLoS ONE
Journal:
PloS one
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10147/221960
DOI:
10.1371/journal.pone.0018394
PubMed ID:
21512583
Abstract:
The extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. eed1Δ cells failed to extend germ tubes into long filaments and switched back to yeast growth after 3 h of incubation during growth on plastic surfaces. Expression of EED1 is regulated by the transcription factor Efg1 and ectopic overexpression of EED1 restored filamentation in efg1Δ. Transcriptional profiling of eed1Δ during infection of oral tissue revealed down-regulation of hyphal associated genes including UME6, encoding another key transcriptional factor. Ectopic overexpression of EED1 or UME6 rescued filamentation and damage potential in eed1Δ. Transcriptional profiling during overexpression of UME6 identified subsets of genes regulated by Eed1 or Ume6. These data suggest that Eed1 and Ume6 act in a pathway regulating maintenance of hyphal growth thereby repressing hyphal-to-yeast transition and permitting dissemination of C. albicans within epithelial tissues.
Item Type:
Article
Language:
en
MeSH:
Candida albicans; Fungal Proteins; Gene Expression Regulation, Fungal; Hyphae
ISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorMartin, Ronnyen_GB
dc.contributor.authorMoran, Gary Pen_GB
dc.contributor.authorJacobsen, Ilse Den_GB
dc.contributor.authorHeyken, Antjeen_GB
dc.contributor.authorDomey, Jennyen_GB
dc.contributor.authorSullivan, Derek Jen_GB
dc.contributor.authorKurzai, Oliveren_GB
dc.contributor.authorHube, Bernharden_GB
dc.date.accessioned2012-05-04T10:44:23Z-
dc.date.available2012-05-04T10:44:23Z-
dc.date.issued2011-04-
dc.identifier.citationThe Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. 2011, 6 (4):e18394 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid21512583-
dc.identifier.doi10.1371/journal.pone.0018394-
dc.identifier.urihttp://hdl.handle.net/10147/221960-
dc.description.abstractThe extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. eed1Δ cells failed to extend germ tubes into long filaments and switched back to yeast growth after 3 h of incubation during growth on plastic surfaces. Expression of EED1 is regulated by the transcription factor Efg1 and ectopic overexpression of EED1 restored filamentation in efg1Δ. Transcriptional profiling of eed1Δ during infection of oral tissue revealed down-regulation of hyphal associated genes including UME6, encoding another key transcriptional factor. Ectopic overexpression of EED1 or UME6 rescued filamentation and damage potential in eed1Δ. Transcriptional profiling during overexpression of UME6 identified subsets of genes regulated by Eed1 or Ume6. These data suggest that Eed1 and Ume6 act in a pathway regulating maintenance of hyphal growth thereby repressing hyphal-to-yeast transition and permitting dissemination of C. albicans within epithelial tissues.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.subject.meshCandida albicans-
dc.subject.meshFungal Proteins-
dc.subject.meshGene Expression Regulation, Fungal-
dc.subject.meshHyphae-
dc.titleThe Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.en_GB
dc.identifier.journalPloS oneen_GB
dc.description.provinceLeinsteren
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