The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.

Hdl Handle:
http://hdl.handle.net/10147/221857
Title:
The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.
Authors:
Park, Sungshim Lani; Lee, Yuan-Chin Amy; Marron, Manuela; Agudo, Antonio; Ahrens, Wolfgang; Barzan, Luigi; Bencko, Vladimir; Benhamou, Simone; Bouchardy, Christine; Canova, Cristina; Castellsague, Xavier; Conway, David I; Healy, Claire M; Holcátová, Ivana; Kjaerheim, Kristina; Lagiou, Pagona; Lowry, Raymond J; Macfarlane, Tatiana V; Macfarlane, Gary J; McCartan, Bernard E; McKinney, Patricia A; Merletti, Franco; Pohlabeln, Hermann; Richiardi, Lorenzo; Simonato, Lorenzo; Sneddon, Linda; Talamini, Renato; Trichopoulos, Dimitrios; Znaor, Ariana; Brennan, Paul; Hashibe, Mia
Affiliation:
Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA.
Citation:
The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study. 2011, 128 (6):1449-61 Int. J. Cancer
Journal:
International journal of cancer. Journal international du cancer
Issue Date:
15-Mar-2011
URI:
http://hdl.handle.net/10147/221857
DOI:
10.1002/ijc.25468
PubMed ID:
20506380
Abstract:
Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-related cancers and genetic susceptibility in Europe study) to investigate the relationship with BMI and adult change in BMI on UADT cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between BMI at three time intervals and BMI change on UADT cancer development, adjusting for center, age, sex, education, fruit and vegetable intake, smoking and alcohol consumption. We found an inverse relationship between UADT cancers and BMI at time of interview and 2 years before interview. No association was found with BMI at 30 years of age. Regarding BMI change between age 30 and 2 years before interview, BMI decrease (BMI change <-5%) vs. BMI stability (-5% ≤ BMI change <5%) showed no overall association with UADT cancers (OR = 1.15; 95% CI = 0.89, 1.49). An increase in BMI (BMI change ≥+5%) was inversely associated with UADT cancers (OR = 0.74; 95% CI = 0.62, 0.89). BMI gain remained inversely associated across all subsites except for esophageal cancer. When stratified by smoking or by drinking, association with BMI gain was detected only in drinkers and smokers. In conclusion, BMI gain is inversely associated with UADT cancers. These findings may be influenced by smoking and/or drinking behaviors and/or the development of preclinical UADT cancers and should be corroborated in studies of a prospective nature.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Alcohol Drinking; Body Mass Index; Case-Control Studies; Esophageal Neoplasms; Europe; Female; Fruit; Humans; Laryngeal Neoplasms; Male; Middle Aged; Mouth Neoplasms; Prognosis; Risk Factors; Smoking
ISSN:
1097-0215

Full metadata record

DC FieldValue Language
dc.contributor.authorPark, Sungshim Lanien_GB
dc.contributor.authorLee, Yuan-Chin Amyen_GB
dc.contributor.authorMarron, Manuelaen_GB
dc.contributor.authorAgudo, Antonioen_GB
dc.contributor.authorAhrens, Wolfgangen_GB
dc.contributor.authorBarzan, Luigien_GB
dc.contributor.authorBencko, Vladimiren_GB
dc.contributor.authorBenhamou, Simoneen_GB
dc.contributor.authorBouchardy, Christineen_GB
dc.contributor.authorCanova, Cristinaen_GB
dc.contributor.authorCastellsague, Xavieren_GB
dc.contributor.authorConway, David Ien_GB
dc.contributor.authorHealy, Claire Men_GB
dc.contributor.authorHolcátová, Ivanaen_GB
dc.contributor.authorKjaerheim, Kristinaen_GB
dc.contributor.authorLagiou, Pagonaen_GB
dc.contributor.authorLowry, Raymond Jen_GB
dc.contributor.authorMacfarlane, Tatiana Ven_GB
dc.contributor.authorMacfarlane, Gary Jen_GB
dc.contributor.authorMcCartan, Bernard Een_GB
dc.contributor.authorMcKinney, Patricia Aen_GB
dc.contributor.authorMerletti, Francoen_GB
dc.contributor.authorPohlabeln, Hermannen_GB
dc.contributor.authorRichiardi, Lorenzoen_GB
dc.contributor.authorSimonato, Lorenzoen_GB
dc.contributor.authorSneddon, Lindaen_GB
dc.contributor.authorTalamini, Renatoen_GB
dc.contributor.authorTrichopoulos, Dimitriosen_GB
dc.contributor.authorZnaor, Arianaen_GB
dc.contributor.authorBrennan, Paulen_GB
dc.contributor.authorHashibe, Miaen_GB
dc.date.accessioned2012-05-03T14:02:40Z-
dc.date.available2012-05-03T14:02:40Z-
dc.date.issued2011-03-15-
dc.identifier.citationThe association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study. 2011, 128 (6):1449-61 Int. J. Canceren_GB
dc.identifier.issn1097-0215-
dc.identifier.pmid20506380-
dc.identifier.doi10.1002/ijc.25468-
dc.identifier.urihttp://hdl.handle.net/10147/221857-
dc.description.abstractPrevious studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-related cancers and genetic susceptibility in Europe study) to investigate the relationship with BMI and adult change in BMI on UADT cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between BMI at three time intervals and BMI change on UADT cancer development, adjusting for center, age, sex, education, fruit and vegetable intake, smoking and alcohol consumption. We found an inverse relationship between UADT cancers and BMI at time of interview and 2 years before interview. No association was found with BMI at 30 years of age. Regarding BMI change between age 30 and 2 years before interview, BMI decrease (BMI change <-5%) vs. BMI stability (-5% ≤ BMI change <5%) showed no overall association with UADT cancers (OR = 1.15; 95% CI = 0.89, 1.49). An increase in BMI (BMI change ≥+5%) was inversely associated with UADT cancers (OR = 0.74; 95% CI = 0.62, 0.89). BMI gain remained inversely associated across all subsites except for esophageal cancer. When stratified by smoking or by drinking, association with BMI gain was detected only in drinkers and smokers. In conclusion, BMI gain is inversely associated with UADT cancers. These findings may be influenced by smoking and/or drinking behaviors and/or the development of preclinical UADT cancers and should be corroborated in studies of a prospective nature.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to International journal of cancer. Journal international du canceren_GB
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAlcohol Drinking-
dc.subject.meshBody Mass Index-
dc.subject.meshCase-Control Studies-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshFruit-
dc.subject.meshHumans-
dc.subject.meshLaryngeal Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMouth Neoplasms-
dc.subject.meshPrognosis-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.titleThe association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA.en_GB
dc.identifier.journalInternational journal of cancer. Journal international du canceren_GB
dc.description.provinceLeinsteren

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