A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

Hdl Handle:
http://hdl.handle.net/10147/221851
Title:
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
Authors:
McKay, James D; Truong, Therese; Gaborieau, Valerie; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, Graham; Zaridze, David; Shangina, Oxana; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Bucur, Alexandru; Bencko, Vladimir; Holcatova, Ivana; Janout, Vladimir; Foretova, Lenka; Lagiou, Pagona; Trichopoulos, Dimitrios; Benhamou, Simone; Bouchardy, Christine; Ahrens, Wolfgang; Merletti, Franco; Richiardi, Lorenzo; Talamini, Renato; Barzan, Luigi; Kjaerheim, Kristina; Macfarlane, Gary J; Macfarlane, Tatiana V; Simonato, Lorenzo; Canova, Cristina; Agudo, Antonio; Castellsagué, Xavier; Lowry, Ray; Conway, David I; McKinney, Patricia A; Healy, Claire M; Toner, Mary E; Znaor, Ariana; Curado, Maria Paula; Koifman, Sergio; Menezes, Ana; Wünsch-Filho, Victor; Neto, José Eluf; Garrote, Leticia Fernández; Boccia, Stefania; Cadoni, Gabriella; Arzani, Dario; Olshan, Andrew F; Weissler, Mark C; Funkhouser, William K; Luo, Jingchun; Lubiński, Jan; Trubicka, Joanna; Lener, Marcin; Oszutowska, Dorota; Schwartz, Stephen M; Chen, Chu; Fish, Sherianne; Doody, David R; Muscat, Joshua E; Lazarus, Philip; Gallagher, Carla J; Chang, Shen-Chih; Zhang, Zuo-Feng; Wei, Qingyi; Sturgis, Erich M; Wang, Li-E; Franceschi, Silvia; Herrero, Rolando; Kelsey, Karl T; McClean, Michael D; Marsit, Carmen J; Nelson, Heather H; Romkes, Marjorie; Buch, Shama; Nukui, Tomoko; Zhong, Shilong; Lacko, Martin; Manni, Johannes J; Peters, Wilbert H M; Hung, Rayjean J; McLaughlin, John; Vatten, Lars; Njølstad, Inger; Goodman, Gary E; Field, John K; Liloglou, Triantafillos; Vineis, Paolo; Clavel-Chapelon, Francoise; Palli, Domenico; Tumino, Rosario; Krogh, Vittorio; Panico, Salvatore; González, Carlos A; Quirós, J Ramón; Martínez, Carmen; Navarro, Carmen; Ardanaz, Eva; Larrañaga, Nerea; Khaw, Kay-Tee; Key, Timothy; Bueno-de-Mesquita, H Bas; Peeters, Petra H M; Trichopoulou, Antonia; Linseisen, Jakob; Boeing, Heiner; Hallmans, Göran; Overvad, Kim; Tjønneland, Anne; Kumle, Merethe; Riboli, Elio; Välk, Kristjan; Vooder, Tõnu; Metspalu, Andres; Zelenika, Diana; Boland, Anne; Delepine, Marc; Foglio, Mario; Lechner, Doris; Blanché, Hélène; Gut, Ivo G; Galan, Pilar; Heath, Simon; Hashibe, Mia; Hayes, Richard B; Boffetta, Paolo; Lathrop, Mark; Brennan, Paul
Affiliation:
International Agency for Research on Cancer (IARC), Lyon, France.
Citation:
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. 2011, 7 (3):e1001333 PLoS Genet.
Journal:
PLoS genetics
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/221851
DOI:
10.1371/journal.pgen.1001333
PubMed ID:
21437268
Abstract:
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p ≤ 5 × 10⁻⁷). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10⁻⁸) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p =2 × 10⁻⁸) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 × 10⁻⁸); rs1229984-ADH1B, p = 7 × 10⁻⁹; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Aldehyde Dehydrogenase; Continental Population Groups; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Head and Neck Neoplasms; Humans; Male; Middle Aged; Risk Factors; Tumor Markers, Biological
ISSN:
1553-7404

Full metadata record

DC FieldValue Language
dc.contributor.authorMcKay, James Den_GB
dc.contributor.authorTruong, Thereseen_GB
dc.contributor.authorGaborieau, Valerieen_GB
dc.contributor.authorChabrier, Amelieen_GB
dc.contributor.authorChuang, Shu-Chunen_GB
dc.contributor.authorByrnes, Grahamen_GB
dc.contributor.authorZaridze, Daviden_GB
dc.contributor.authorShangina, Oxanaen_GB
dc.contributor.authorSzeszenia-Dabrowska, Neonilaen_GB
dc.contributor.authorLissowska, Jolantaen_GB
dc.contributor.authorRudnai, Peteren_GB
dc.contributor.authorFabianova, Eleonoraen_GB
dc.contributor.authorBucur, Alexandruen_GB
dc.contributor.authorBencko, Vladimiren_GB
dc.contributor.authorHolcatova, Ivanaen_GB
dc.contributor.authorJanout, Vladimiren_GB
dc.contributor.authorForetova, Lenkaen_GB
dc.contributor.authorLagiou, Pagonaen_GB
dc.contributor.authorTrichopoulos, Dimitriosen_GB
dc.contributor.authorBenhamou, Simoneen_GB
dc.contributor.authorBouchardy, Christineen_GB
dc.contributor.authorAhrens, Wolfgangen_GB
dc.contributor.authorMerletti, Francoen_GB
dc.contributor.authorRichiardi, Lorenzoen_GB
dc.contributor.authorTalamini, Renatoen_GB
dc.contributor.authorBarzan, Luigien_GB
dc.contributor.authorKjaerheim, Kristinaen_GB
dc.contributor.authorMacfarlane, Gary Jen_GB
dc.contributor.authorMacfarlane, Tatiana Ven_GB
dc.contributor.authorSimonato, Lorenzoen_GB
dc.contributor.authorCanova, Cristinaen_GB
dc.contributor.authorAgudo, Antonioen_GB
dc.contributor.authorCastellsagué, Xavieren_GB
dc.contributor.authorLowry, Rayen_GB
dc.contributor.authorConway, David Ien_GB
dc.contributor.authorMcKinney, Patricia Aen_GB
dc.contributor.authorHealy, Claire Men_GB
dc.contributor.authorToner, Mary Een_GB
dc.contributor.authorZnaor, Arianaen_GB
dc.contributor.authorCurado, Maria Paulaen_GB
dc.contributor.authorKoifman, Sergioen_GB
dc.contributor.authorMenezes, Anaen_GB
dc.contributor.authorWünsch-Filho, Victoren_GB
dc.contributor.authorNeto, José Elufen_GB
dc.contributor.authorGarrote, Leticia Fernándezen_GB
dc.contributor.authorBoccia, Stefaniaen_GB
dc.contributor.authorCadoni, Gabriellaen_GB
dc.contributor.authorArzani, Darioen_GB
dc.contributor.authorOlshan, Andrew Fen_GB
dc.contributor.authorWeissler, Mark Cen_GB
dc.contributor.authorFunkhouser, William Ken_GB
dc.contributor.authorLuo, Jingchunen_GB
dc.contributor.authorLubiński, Janen_GB
dc.contributor.authorTrubicka, Joannaen_GB
dc.contributor.authorLener, Marcinen_GB
dc.contributor.authorOszutowska, Dorotaen_GB
dc.contributor.authorSchwartz, Stephen Men_GB
dc.contributor.authorChen, Chuen_GB
dc.contributor.authorFish, Sherianneen_GB
dc.contributor.authorDoody, David Ren_GB
dc.contributor.authorMuscat, Joshua Een_GB
dc.contributor.authorLazarus, Philipen_GB
dc.contributor.authorGallagher, Carla Jen_GB
dc.contributor.authorChang, Shen-Chihen_GB
dc.contributor.authorZhang, Zuo-Fengen_GB
dc.contributor.authorWei, Qingyien_GB
dc.contributor.authorSturgis, Erich Men_GB
dc.contributor.authorWang, Li-Een_GB
dc.contributor.authorFranceschi, Silviaen_GB
dc.contributor.authorHerrero, Rolandoen_GB
dc.contributor.authorKelsey, Karl Ten_GB
dc.contributor.authorMcClean, Michael Den_GB
dc.contributor.authorMarsit, Carmen Jen_GB
dc.contributor.authorNelson, Heather Hen_GB
dc.contributor.authorRomkes, Marjorieen_GB
dc.contributor.authorBuch, Shamaen_GB
dc.contributor.authorNukui, Tomokoen_GB
dc.contributor.authorZhong, Shilongen_GB
dc.contributor.authorLacko, Martinen_GB
dc.contributor.authorManni, Johannes Jen_GB
dc.contributor.authorPeters, Wilbert H Men_GB
dc.contributor.authorHung, Rayjean Jen_GB
dc.contributor.authorMcLaughlin, Johnen_GB
dc.contributor.authorVatten, Larsen_GB
dc.contributor.authorNjølstad, Ingeren_GB
dc.contributor.authorGoodman, Gary Een_GB
dc.contributor.authorField, John Ken_GB
dc.contributor.authorLiloglou, Triantafillosen_GB
dc.contributor.authorVineis, Paoloen_GB
dc.contributor.authorClavel-Chapelon, Francoiseen_GB
dc.contributor.authorPalli, Domenicoen_GB
dc.contributor.authorTumino, Rosarioen_GB
dc.contributor.authorKrogh, Vittorioen_GB
dc.contributor.authorPanico, Salvatoreen_GB
dc.contributor.authorGonzález, Carlos Aen_GB
dc.contributor.authorQuirós, J Ramónen_GB
dc.contributor.authorMartínez, Carmenen_GB
dc.contributor.authorNavarro, Carmenen_GB
dc.contributor.authorArdanaz, Evaen_GB
dc.contributor.authorLarrañaga, Nereaen_GB
dc.contributor.authorKhaw, Kay-Teeen_GB
dc.contributor.authorKey, Timothyen_GB
dc.contributor.authorBueno-de-Mesquita, H Basen_GB
dc.contributor.authorPeeters, Petra H Men_GB
dc.contributor.authorTrichopoulou, Antoniaen_GB
dc.contributor.authorLinseisen, Jakoben_GB
dc.contributor.authorBoeing, Heineren_GB
dc.contributor.authorHallmans, Göranen_GB
dc.contributor.authorOvervad, Kimen_GB
dc.contributor.authorTjønneland, Anneen_GB
dc.contributor.authorKumle, Meretheen_GB
dc.contributor.authorRiboli, Elioen_GB
dc.contributor.authorVälk, Kristjanen_GB
dc.contributor.authorVooder, Tõnuen_GB
dc.contributor.authorMetspalu, Andresen_GB
dc.contributor.authorZelenika, Dianaen_GB
dc.contributor.authorBoland, Anneen_GB
dc.contributor.authorDelepine, Marcen_GB
dc.contributor.authorFoglio, Marioen_GB
dc.contributor.authorLechner, Dorisen_GB
dc.contributor.authorBlanché, Hélèneen_GB
dc.contributor.authorGut, Ivo Gen_GB
dc.contributor.authorGalan, Pilaren_GB
dc.contributor.authorHeath, Simonen_GB
dc.contributor.authorHashibe, Miaen_GB
dc.contributor.authorHayes, Richard Ben_GB
dc.contributor.authorBoffetta, Paoloen_GB
dc.contributor.authorLathrop, Marken_GB
dc.contributor.authorBrennan, Paulen_GB
dc.date.accessioned2012-05-03T12:55:25Z-
dc.date.available2012-05-03T12:55:25Z-
dc.date.issued2011-03-
dc.identifier.citationA genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. 2011, 7 (3):e1001333 PLoS Genet.en_GB
dc.identifier.issn1553-7404-
dc.identifier.pmid21437268-
dc.identifier.doi10.1371/journal.pgen.1001333-
dc.identifier.urihttp://hdl.handle.net/10147/221851-
dc.description.abstractGenome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p ≤ 5 × 10⁻⁷). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10⁻⁸) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p =2 × 10⁻⁸) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 × 10⁻⁸); rs1229984-ADH1B, p = 7 × 10⁻⁹; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PLoS geneticsen_GB
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAldehyde Dehydrogenase-
dc.subject.meshContinental Population Groups-
dc.subject.meshFemale-
dc.subject.meshGene Frequency-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenetic Variation-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRisk Factors-
dc.subject.meshTumor Markers, Biological-
dc.titleA genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.en_GB
dc.typeArticleen
dc.contributor.departmentInternational Agency for Research on Cancer (IARC), Lyon, France.en_GB
dc.identifier.journalPLoS geneticsen_GB
dc.description.provinceLeinsteren

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