Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer.

Hdl Handle:
http://hdl.handle.net/10147/221826
Title:
Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer.
Authors:
Anantharaman, Devasena; Marron, Manuela; Lagiou, Pagona; Samoli, Evangelia; Ahrens, Wolfgang; Pohlabeln, Hermann; Slamova, Alena; Schejbalova, Miriam; Merletti, Franco; Richiardi, Lorenzo; Kjaerheim, Kristina; Castellsague, Xavier; Agudo, Antonio; Talamini, Renato; Barzan, Luigi; Macfarlane, Tatiana V; Tickle, Martin; Simonato, Lorenzo; Canova, Cristina; Conway, David I; McKinney, Patricia A; Thomson, Peter; Znaor, Ariana; Healy, Claire M; McCartan, Bernard E; Hashibe, Mia; Brennan, Paul; Macfarlane, Gary J
Affiliation:
International Agency for Research on Cancer, Lyon, France.
Citation:
Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. 2011, 47 (8):725-31 Oral Oncol.
Journal:
Oral oncology
Issue Date:
Aug-2011
URI:
http://hdl.handle.net/10147/221826
DOI:
10.1016/j.oraloncology.2011.05.004
PubMed ID:
21684805
Abstract:
Tobacco and alcohol are major risk factors for upper aerodigestive tract (UADT) cancer and significant variation is observed in UADT cancer rates across Europe. We have estimated the proportion of UADT cancer burden explained by tobacco and alcohol and how this varies with the incidence rates across Europe, cancer sub-site, gender and age. This should help estimate the minimum residual burden of other risk factors to UADT cancer, including human papillomavirus. We analysed 1981 UADT cancer cases and 1993 controls from the ARCAGE multicentre study. We estimated the population attributable risk (PAR) of tobacco alone, alcohol alone and their joint effect. Tobacco and alcohol together explained 73% of UADT cancer burden of which nearly 29% was explained by smoking alone, less than 1% due to alcohol on its own and 44% by the joint effect of tobacco and alcohol. Tobacco and alcohol together explained a larger proportion of hypopharyngeal/laryngeal cancer (PAR=85%) than oropharyngeal (PAR=74%), esophageal (PAR=67%) and oral cancer (PAR=61%). Tobacco and alcohol together explain only about half of the total UADT cancer burden among women. Geographically, tobacco and alcohol explained a larger proportion of UADT cancer in central (PAR=84%) than southern (PAR=72%) and western Europe (PAR=67%). While the majority of the UADT cancers in Europe are due to tobacco or the joint effect of tobacco and alcohol, our results support a significant role for other risk factors in particular, for oral and oropharyngeal cancers and also for UADT cancers in southern and western Europe.
Item Type:
Article
Language:
en
MeSH:
Adult; Alcohol Drinking; Case-Control Studies; Esophageal Neoplasms; Europe; Female; Humans; Incidence; Male; Middle Aged; Mouth Neoplasms; Otorhinolaryngologic Neoplasms; Risk Factors; Smoking
ISSN:
1368-8375

Full metadata record

DC FieldValue Language
dc.contributor.authorAnantharaman, Devasenaen_GB
dc.contributor.authorMarron, Manuelaen_GB
dc.contributor.authorLagiou, Pagonaen_GB
dc.contributor.authorSamoli, Evangeliaen_GB
dc.contributor.authorAhrens, Wolfgangen_GB
dc.contributor.authorPohlabeln, Hermannen_GB
dc.contributor.authorSlamova, Alenaen_GB
dc.contributor.authorSchejbalova, Miriamen_GB
dc.contributor.authorMerletti, Francoen_GB
dc.contributor.authorRichiardi, Lorenzoen_GB
dc.contributor.authorKjaerheim, Kristinaen_GB
dc.contributor.authorCastellsague, Xavieren_GB
dc.contributor.authorAgudo, Antonioen_GB
dc.contributor.authorTalamini, Renatoen_GB
dc.contributor.authorBarzan, Luigien_GB
dc.contributor.authorMacfarlane, Tatiana Ven_GB
dc.contributor.authorTickle, Martinen_GB
dc.contributor.authorSimonato, Lorenzoen_GB
dc.contributor.authorCanova, Cristinaen_GB
dc.contributor.authorConway, David Ien_GB
dc.contributor.authorMcKinney, Patricia Aen_GB
dc.contributor.authorThomson, Peteren_GB
dc.contributor.authorZnaor, Arianaen_GB
dc.contributor.authorHealy, Claire Men_GB
dc.contributor.authorMcCartan, Bernard Een_GB
dc.contributor.authorHashibe, Miaen_GB
dc.contributor.authorBrennan, Paulen_GB
dc.contributor.authorMacfarlane, Gary Jen_GB
dc.date.accessioned2012-05-03T12:38:17Z-
dc.date.available2012-05-03T12:38:17Z-
dc.date.issued2011-08-
dc.identifier.citationPopulation attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. 2011, 47 (8):725-31 Oral Oncol.en_GB
dc.identifier.issn1368-8375-
dc.identifier.pmid21684805-
dc.identifier.doi10.1016/j.oraloncology.2011.05.004-
dc.identifier.urihttp://hdl.handle.net/10147/221826-
dc.description.abstractTobacco and alcohol are major risk factors for upper aerodigestive tract (UADT) cancer and significant variation is observed in UADT cancer rates across Europe. We have estimated the proportion of UADT cancer burden explained by tobacco and alcohol and how this varies with the incidence rates across Europe, cancer sub-site, gender and age. This should help estimate the minimum residual burden of other risk factors to UADT cancer, including human papillomavirus. We analysed 1981 UADT cancer cases and 1993 controls from the ARCAGE multicentre study. We estimated the population attributable risk (PAR) of tobacco alone, alcohol alone and their joint effect. Tobacco and alcohol together explained 73% of UADT cancer burden of which nearly 29% was explained by smoking alone, less than 1% due to alcohol on its own and 44% by the joint effect of tobacco and alcohol. Tobacco and alcohol together explained a larger proportion of hypopharyngeal/laryngeal cancer (PAR=85%) than oropharyngeal (PAR=74%), esophageal (PAR=67%) and oral cancer (PAR=61%). Tobacco and alcohol together explain only about half of the total UADT cancer burden among women. Geographically, tobacco and alcohol explained a larger proportion of UADT cancer in central (PAR=84%) than southern (PAR=72%) and western Europe (PAR=67%). While the majority of the UADT cancers in Europe are due to tobacco or the joint effect of tobacco and alcohol, our results support a significant role for other risk factors in particular, for oral and oropharyngeal cancers and also for UADT cancers in southern and western Europe.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Oral oncologyen_GB
dc.subject.meshAdult-
dc.subject.meshAlcohol Drinking-
dc.subject.meshCase-Control Studies-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMouth Neoplasms-
dc.subject.meshOtorhinolaryngologic Neoplasms-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.titlePopulation attributable risk of tobacco and alcohol for upper aerodigestive tract cancer.en_GB
dc.typeArticleen
dc.contributor.departmentInternational Agency for Research on Cancer, Lyon, France.en_GB
dc.identifier.journalOral oncologyen_GB
dc.description.provinceLeinsteren

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