From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase.

Hdl Handle:
http://hdl.handle.net/10147/221817
Title:
From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase.
Authors:
Olivieri, Aldo; Rico, Daniel; Khiari, Zhied; Henehan, Gary; O'Sullivan, Jeff; Tipton, Keith
Affiliation:
School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. oliviera@tcd.ie
Citation:
From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase. 2011, 118 (7):1079-89 J Neural Transm
Journal:
Journal of neural transmission (Vienna, Austria : 1996)
Issue Date:
Jul-2011
URI:
http://hdl.handle.net/10147/221817
DOI:
10.1007/s00702-011-0611-z
PubMed ID:
21373760
Abstract:
Tissue bound primary amine oxidase (PrAO) and its circulating plasma-soluble form are involved, through their catalytic activity, in important cellular roles, including the adhesion of lymphocytes to endothelial cells during various inflammatory conditions, the regulation of cell growth and maturation, extracellular matrix deposition and maturation and glucose transport. PrAO catalyses the oxidative deamination of several xenobiotics and has been linked to vascular toxicity, due to the generation of cytotoxic aldehydes. In this study, a series of amines and aldehydes contained in food and drugs were tested via a high-throughput assay as potential substrates or inhibitors of bovine plasma PrAO. Although none of the compounds analyzed were found to be substrates for the enzyme, a series of molecules, including caffeine, the antidiabetics phenformin and tolbutamide and the antimicrobial pentamidine, were identified as PrAO inhibitors. Although the inhibition observed was in the millimolar and micromolar range, these data show that further work will be necessary to elucidate whether the interaction of ingested biogenic or xenobiotic amines with PrAO might adversely affect its biological roles.
Item Type:
Article
Language:
en
ISSN:
1435-1463

Full metadata record

DC FieldValue Language
dc.contributor.authorOlivieri, Aldoen_GB
dc.contributor.authorRico, Danielen_GB
dc.contributor.authorKhiari, Zhieden_GB
dc.contributor.authorHenehan, Garyen_GB
dc.contributor.authorO'Sullivan, Jeffen_GB
dc.contributor.authorTipton, Keithen_GB
dc.date.accessioned2012-05-03T09:56:19Z-
dc.date.available2012-05-03T09:56:19Z-
dc.date.issued2011-07-
dc.identifier.citationFrom caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase. 2011, 118 (7):1079-89 J Neural Transmen_GB
dc.identifier.issn1435-1463-
dc.identifier.pmid21373760-
dc.identifier.doi10.1007/s00702-011-0611-z-
dc.identifier.urihttp://hdl.handle.net/10147/221817-
dc.description.abstractTissue bound primary amine oxidase (PrAO) and its circulating plasma-soluble form are involved, through their catalytic activity, in important cellular roles, including the adhesion of lymphocytes to endothelial cells during various inflammatory conditions, the regulation of cell growth and maturation, extracellular matrix deposition and maturation and glucose transport. PrAO catalyses the oxidative deamination of several xenobiotics and has been linked to vascular toxicity, due to the generation of cytotoxic aldehydes. In this study, a series of amines and aldehydes contained in food and drugs were tested via a high-throughput assay as potential substrates or inhibitors of bovine plasma PrAO. Although none of the compounds analyzed were found to be substrates for the enzyme, a series of molecules, including caffeine, the antidiabetics phenformin and tolbutamide and the antimicrobial pentamidine, were identified as PrAO inhibitors. Although the inhibition observed was in the millimolar and micromolar range, these data show that further work will be necessary to elucidate whether the interaction of ingested biogenic or xenobiotic amines with PrAO might adversely affect its biological roles.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Journal of neural transmission (Vienna, Austria : 1996)en_GB
dc.titleFrom caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase.en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. oliviera@tcd.ieen_GB
dc.identifier.journalJournal of neural transmission (Vienna, Austria : 1996)en_GB
dc.description.provinceLeinsteren
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