Nonadherence to medication four years after a first episode of psychosis and associated risk factors.

Hdl Handle:
http://hdl.handle.net/10147/221216
Title:
Nonadherence to medication four years after a first episode of psychosis and associated risk factors.
Authors:
Hill, Michele; Crumlish, Niall; Whitty, Petter; Clarke, Mary; Browne, Stephen; Kamali, Moayyad; Kinsella, Anthony; Waddington, John L; Larkin, Conall; O'Callaghan, Eadbhard
Affiliation:
St. John of God Adult Psychiatric Service, Cluain Mhuire Family Centre, Dublin, Ireland.
Citation:
Nonadherence to medication four years after a first episode of psychosis and associated risk factors. 2010, 61 (2):189-92 Psychiatr Serv
Journal:
Psychiatric services (Washington, D.C.)
Issue Date:
Feb-2010
URI:
http://hdl.handle.net/10147/221216
DOI:
10.1176/appi.ps.61.2.189
PubMed ID:
20123826
Abstract:
This study examined concurrent associations and predictors at first indication of nonadherence to antipsychotic medication four years after a first episode of psychosis.; A prospective cohort of 171 patients in urban Ireland with a first episode of psychosis was followed up four years after inception (follow-up primary analysis, N=84; secondary analysis, N=104).; At the four-year follow-up 76% were adherent and 24% were not. Nonadherence was concurrently associated with substance misuse (p<.01), increased symptomatology (p<.01), less insight (p=.01), lower global functioning (p<.01), and negative attitudes toward medication (p<.01). Compared with other patients, those who were nonadherent had more readmissions (p=.01). Predictors of future nonadherence were substance misuse (p=.02) and duration of untreated psychosis (p=.04).; This prospective investigation confirms previous cross-sectional studies. The association between longer duration of untreated psychosis and nonadherence warrants further research because it could be interpreted as further evidence of the importance of early intervention.
Item Type:
Article
Language:
en
MeSH:
Adult; Antipsychotic Agents; Cohort Studies; Comorbidity; Female; Follow-Up Studies; Humans; Ireland; Male; Medication Adherence; Middle Aged; Outcome Assessment (Health Care); Patient Readmission; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Social Adjustment; Substance-Related Disorders; Urban Population; Young Adult
ISSN:
1557-9700

Full metadata record

DC FieldValue Language
dc.contributor.authorHill, Micheleen_GB
dc.contributor.authorCrumlish, Niallen_GB
dc.contributor.authorWhitty, Petteren_GB
dc.contributor.authorClarke, Maryen_GB
dc.contributor.authorBrowne, Stephenen_GB
dc.contributor.authorKamali, Moayyaden_GB
dc.contributor.authorKinsella, Anthonyen_GB
dc.contributor.authorWaddington, John Len_GB
dc.contributor.authorLarkin, Conallen_GB
dc.contributor.authorO'Callaghan, Eadbharden_GB
dc.date.accessioned2012-04-30T15:43:01Z-
dc.date.available2012-04-30T15:43:01Z-
dc.date.issued2010-02-
dc.identifier.citationNonadherence to medication four years after a first episode of psychosis and associated risk factors. 2010, 61 (2):189-92 Psychiatr Serven_GB
dc.identifier.issn1557-9700-
dc.identifier.pmid20123826-
dc.identifier.doi10.1176/appi.ps.61.2.189-
dc.identifier.urihttp://hdl.handle.net/10147/221216-
dc.description.abstractThis study examined concurrent associations and predictors at first indication of nonadherence to antipsychotic medication four years after a first episode of psychosis.-
dc.description.abstractA prospective cohort of 171 patients in urban Ireland with a first episode of psychosis was followed up four years after inception (follow-up primary analysis, N=84; secondary analysis, N=104).-
dc.description.abstractAt the four-year follow-up 76% were adherent and 24% were not. Nonadherence was concurrently associated with substance misuse (p<.01), increased symptomatology (p<.01), less insight (p=.01), lower global functioning (p<.01), and negative attitudes toward medication (p<.01). Compared with other patients, those who were nonadherent had more readmissions (p=.01). Predictors of future nonadherence were substance misuse (p=.02) and duration of untreated psychosis (p=.04).-
dc.description.abstractThis prospective investigation confirms previous cross-sectional studies. The association between longer duration of untreated psychosis and nonadherence warrants further research because it could be interpreted as further evidence of the importance of early intervention.-
dc.language.isoenen
dc.rightsArchived with thanks to Psychiatric services (Washington, D.C.)en_GB
dc.subject.meshAdult-
dc.subject.meshAntipsychotic Agents-
dc.subject.meshCohort Studies-
dc.subject.meshComorbidity-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshMedication Adherence-
dc.subject.meshMiddle Aged-
dc.subject.meshOutcome Assessment (Health Care)-
dc.subject.meshPatient Readmission-
dc.subject.meshProspective Studies-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshPsychotic Disorders-
dc.subject.meshSocial Adjustment-
dc.subject.meshSubstance-Related Disorders-
dc.subject.meshUrban Population-
dc.subject.meshYoung Adult-
dc.titleNonadherence to medication four years after a first episode of psychosis and associated risk factors.en_GB
dc.typeArticleen
dc.contributor.departmentSt. John of God Adult Psychiatric Service, Cluain Mhuire Family Centre, Dublin, Ireland.en_GB
dc.identifier.journalPsychiatric services (Washington, D.C.)en_GB

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