Fatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis.

2.50
Hdl Handle:
http://hdl.handle.net/10147/221214
Title:
Fatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis.
Authors:
Minnock, Patricia; Kirwan, John; Veale, Douglas; Fitzgerald, Oliver; Bresnihan, Barry
Affiliation:
Rheumatology Rehabilitation, Our Lady's Hospice, Dublin, and School of Nursing and Midwifery, Trinity College, Dublin, Ireland. pminnock@olh.ie
Citation:
Fatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis., 28 (3):401-4 Clin. Exp. Rheumatol.
Journal:
Clinical and experimental rheumatology
Issue Date:
2010
URI:
http://hdl.handle.net/10147/221214
PubMed ID:
20525443
Abstract:
This pilot study examined sensitivity to change and relative independence of fatigue as an outcome measure in patients with psoriatic arthritis (PsA) following anti-TNF therapy.; Patients with PsA commencing anti-TNF therapy were evaluated at baseline and at 3 months. Fatigue was measured using a 0-10 numeric rating scale (NRS). This was a one-dimensional 11-point NRS with anchors of 0 (none) and 10 (a great deal). The words 'none' and 'a great deal' were placed under the NRS corresponding to the anchors 0 and 10, respectively. Sensitivity to change of fatigue was compared with recognised core outcomes and determined by calculating the standardised response means. Multiple regression analysis was employed to determine predictors of fatigue and their independent variance.; Forty-one patients were evaluated. Mean (SD) fatigue levels were 5.6 (2.3) and 3.6 (2.2) (p=0.001) at baseline and at 3-months, respectively. Using the SRM, fatigue ranked sixth relative to the other measures demonstrating a moderate sensitivity to change. Noteworthy was the observation that fatigue was ranked higher than CRP. The relative independent variance in fatigue of 27% was greater than that of the core clinical measures: HAQ 21%, TJC 14%, Pain 4%, SJC 0.4%, GH 0.4%, and less than that of the laboratory measure CRP 33%.; This study demonstrated that fatigue is an independent outcome measure and is sensitive to change in patients with PsA.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Fatigue; Female; Humans; Linear Models; Male; Middle Aged; Outcome Assessment (Health Care); Pain; Pilot Projects; Sensitivity and Specificity; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult
ISSN:
0392-856X

Full metadata record

DC FieldValue Language
dc.contributor.authorMinnock, Patriciaen_GB
dc.contributor.authorKirwan, Johnen_GB
dc.contributor.authorVeale, Douglasen_GB
dc.contributor.authorFitzgerald, Oliveren_GB
dc.contributor.authorBresnihan, Barryen_GB
dc.date.accessioned2012-04-30T15:42:48Z-
dc.date.available2012-04-30T15:42:48Z-
dc.date.issued2010-
dc.identifier.citationFatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis., 28 (3):401-4 Clin. Exp. Rheumatol.en_GB
dc.identifier.issn0392-856X-
dc.identifier.pmid20525443-
dc.identifier.urihttp://hdl.handle.net/10147/221214-
dc.description.abstractThis pilot study examined sensitivity to change and relative independence of fatigue as an outcome measure in patients with psoriatic arthritis (PsA) following anti-TNF therapy.-
dc.description.abstractPatients with PsA commencing anti-TNF therapy were evaluated at baseline and at 3 months. Fatigue was measured using a 0-10 numeric rating scale (NRS). This was a one-dimensional 11-point NRS with anchors of 0 (none) and 10 (a great deal). The words 'none' and 'a great deal' were placed under the NRS corresponding to the anchors 0 and 10, respectively. Sensitivity to change of fatigue was compared with recognised core outcomes and determined by calculating the standardised response means. Multiple regression analysis was employed to determine predictors of fatigue and their independent variance.-
dc.description.abstractForty-one patients were evaluated. Mean (SD) fatigue levels were 5.6 (2.3) and 3.6 (2.2) (p=0.001) at baseline and at 3-months, respectively. Using the SRM, fatigue ranked sixth relative to the other measures demonstrating a moderate sensitivity to change. Noteworthy was the observation that fatigue was ranked higher than CRP. The relative independent variance in fatigue of 27% was greater than that of the core clinical measures: HAQ 21%, TJC 14%, Pain 4%, SJC 0.4%, GH 0.4%, and less than that of the laboratory measure CRP 33%.-
dc.description.abstractThis study demonstrated that fatigue is an independent outcome measure and is sensitive to change in patients with PsA.-
dc.language.isoenen
dc.rightsArchived with thanks to Clinical and experimental rheumatologyen_GB
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntirheumatic Agents-
dc.subject.meshArthritis, Psoriatic-
dc.subject.meshFatigue-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLinear Models-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOutcome Assessment (Health Care)-
dc.subject.meshPain-
dc.subject.meshPilot Projects-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshTreatment Outcome-
dc.subject.meshTumor Necrosis Factor-alpha-
dc.subject.meshYoung Adult-
dc.titleFatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis.en_GB
dc.typeArticleen
dc.contributor.departmentRheumatology Rehabilitation, Our Lady's Hospice, Dublin, and School of Nursing and Midwifery, Trinity College, Dublin, Ireland. pminnock@olh.ieen_GB
dc.identifier.journalClinical and experimental rheumatologyen_GB

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