Randomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFα therapy medication.

2.50
Hdl Handle:
http://hdl.handle.net/10147/221212
Title:
Randomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFα therapy medication.
Authors:
Reid, Angela; Brady, Audrey; Blake, Catherine; Mongey, Anne-Barbara; Veale, Douglas J; FitzGerald, Oliver; Cusack, Tara
Affiliation:
Physiotherapy Department, Our Lady's Hospice and Care Services, Harold's Cross, Dublin, Ireland. angelatreid@hotmail.com
Citation:
Randomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFα therapy medication. 2011, 12:11 BMC Musculoskelet Disord
Journal:
BMC musculoskeletal disorders
Issue Date:
2011
URI:
http://hdl.handle.net/10147/221212
DOI:
10.1186/1471-2474-12-11
PubMed ID:
21232112
Abstract:
Substantial progress has been made in the medical management of rheumatoid arthritis (RA) over the past decade with the introduction of biologic therapies, including anti-tumour necrosis factor alpha (anti-TNFα) therapy medications. However, individuals with RA taking anti-TNFα medication continue to experience physical, psychological and functional consequences, which could potentially benefit from rehabilitation. There is evidence that therapeutic exercise should be included as an intervention for people with RA, but to date there is little evidence of the benefits of therapeutic exercise for people with RA on anti-TNFα therapy medication. A protocol for a multicentre randomised controlled three-armed study which aims to examine the effect of dynamic group exercise therapy on land or in water for people with RA taking anti-TNFα therapy medication is described.; Six hundred and eighteen individuals with RA, on anti-TNFα therapy medication, will be randomised into one of 3 groups: a land-based exercise group; a water-based exercise group or a control group. The land and water-based groups will exercise for one hour, twice a week for eight weeks. The control group will receive no intervention and will be asked not to alter their exercise habits for the duration of the study. The primary outcome measure, the Stanford Health Assessment Questionnaire Disability Index (HAQ-DI) which measures functional ability, and secondary measures of pain, fatigue and quality of life, will be assessed at baseline, eight and 24 weeks by an independent assessor unaware of group allocation. Changes in outcome from 0 to 8 weeks and 0 to 24 weeks in the 'land-based exercise group versus control group' and the 'water-based exercise group versus control group' will be examined. Analysis will be conducted on an intention to treat basis.; This trial will evaluate the effectiveness of group exercise therapy on land or in water, for people with RA taking anti-TNFα therapy medication. If these exercise groups are found to be beneficial, they could be conducted in local community facilities thus making these forms of exercise more easily accessible for individuals and potentially reduce the burden on health services.; This trial is registered with ClinicalTrials.gov (a service of the United States National Institutes of Health) identifier: NCT00855322.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Exercise Therapy; Female; Humans; Male; Middle Aged; Physical Fitness; Tumor Necrosis Factor-alpha; Young Adult
ISSN:
1471-2474

Full metadata record

DC FieldValue Language
dc.contributor.authorReid, Angelaen_GB
dc.contributor.authorBrady, Audreyen_GB
dc.contributor.authorBlake, Catherineen_GB
dc.contributor.authorMongey, Anne-Barbaraen_GB
dc.contributor.authorVeale, Douglas Jen_GB
dc.contributor.authorFitzGerald, Oliveren_GB
dc.contributor.authorCusack, Taraen_GB
dc.date.accessioned2012-04-30T15:42:22Z-
dc.date.available2012-04-30T15:42:22Z-
dc.date.issued2011-
dc.identifier.citationRandomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFα therapy medication. 2011, 12:11 BMC Musculoskelet Disorden_GB
dc.identifier.issn1471-2474-
dc.identifier.pmid21232112-
dc.identifier.doi10.1186/1471-2474-12-11-
dc.identifier.urihttp://hdl.handle.net/10147/221212-
dc.description.abstractSubstantial progress has been made in the medical management of rheumatoid arthritis (RA) over the past decade with the introduction of biologic therapies, including anti-tumour necrosis factor alpha (anti-TNFα) therapy medications. However, individuals with RA taking anti-TNFα medication continue to experience physical, psychological and functional consequences, which could potentially benefit from rehabilitation. There is evidence that therapeutic exercise should be included as an intervention for people with RA, but to date there is little evidence of the benefits of therapeutic exercise for people with RA on anti-TNFα therapy medication. A protocol for a multicentre randomised controlled three-armed study which aims to examine the effect of dynamic group exercise therapy on land or in water for people with RA taking anti-TNFα therapy medication is described.-
dc.description.abstractSix hundred and eighteen individuals with RA, on anti-TNFα therapy medication, will be randomised into one of 3 groups: a land-based exercise group; a water-based exercise group or a control group. The land and water-based groups will exercise for one hour, twice a week for eight weeks. The control group will receive no intervention and will be asked not to alter their exercise habits for the duration of the study. The primary outcome measure, the Stanford Health Assessment Questionnaire Disability Index (HAQ-DI) which measures functional ability, and secondary measures of pain, fatigue and quality of life, will be assessed at baseline, eight and 24 weeks by an independent assessor unaware of group allocation. Changes in outcome from 0 to 8 weeks and 0 to 24 weeks in the 'land-based exercise group versus control group' and the 'water-based exercise group versus control group' will be examined. Analysis will be conducted on an intention to treat basis.-
dc.description.abstractThis trial will evaluate the effectiveness of group exercise therapy on land or in water, for people with RA taking anti-TNFα therapy medication. If these exercise groups are found to be beneficial, they could be conducted in local community facilities thus making these forms of exercise more easily accessible for individuals and potentially reduce the burden on health services.-
dc.description.abstractThis trial is registered with ClinicalTrials.gov (a service of the United States National Institutes of Health) identifier: NCT00855322.-
dc.language.isoenen
dc.rightsArchived with thanks to BMC musculoskeletal disordersen_GB
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntirheumatic Agents-
dc.subject.meshArthritis, Rheumatoid-
dc.subject.meshExercise Therapy-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPhysical Fitness-
dc.subject.meshTumor Necrosis Factor-alpha-
dc.subject.meshYoung Adult-
dc.titleRandomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFα therapy medication.en_GB
dc.typeArticleen
dc.contributor.departmentPhysiotherapy Department, Our Lady's Hospice and Care Services, Harold's Cross, Dublin, Ireland. angelatreid@hotmail.comen_GB
dc.identifier.journalBMC musculoskeletal disordersen_GB
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