Trimester-specific reference intervals for haemoglobin A(1c) (HbA(1c)) in pregnancy.

Hdl Handle:
http://hdl.handle.net/10147/220231
Title:
Trimester-specific reference intervals for haemoglobin A(1c) (HbA(1c)) in pregnancy.
Authors:
O'Connor, Catherine; O'Shea, Paula Mary; Owens, Lisa Ann; Carmody, Louise; Avalos, Gloria; Nestor, Laura; Lydon, Katherine; Dunne, Fidelma
Affiliation:
Department of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.
Citation:
Trimester-specific reference intervals for haemoglobin A(1c) (HbA(1c)) in pregnancy. 2011: Clin. Chem. Lab. Med.
Journal:
Clinical chemistry and laboratory medicine : CCLM / FESCC
Issue Date:
26-Nov-2011
URI:
http://hdl.handle.net/10147/220231
DOI:
10.1515/CCLM.2011.397
PubMed ID:
22117781
Abstract:
Abstract Background: Diabetes in pregnancy imposes additional risks to both mother and infant. These increased risks are considered to be primarily related to glycaemic control which is monitored by means of glycated haemoglobin (HbA(1c)). The correlation of HbA(1c) with clinical outcomes emphasises the need to measure HbA(1c) accurately, precisely and for correct interpretation, comparison to appropriately defined reference intervals. Since July 2010, the HbA(1c) assay in Irish laboratories is fully metrologically traceable to the IFCC standard. The objective was to establish trimester-specific reference intervals in pregnancy for IFCC standardised HbA(1c) in non-diabetic Caucasian women. Methods: The authors recruited 311 non-diabetic Caucasian pregnant (n=246) and non-pregnant women (n=65). A selective screening based on risk factors for gestational diabetes was employed. All subjects had a random plasma glucose <7.7 mmol/L and normal haemoglobin level. Pregnancy trimester was defined as trimester 1 (T1, n=40) up to 12 weeks +6 days, trimester 2 (T2, n=106) 13-27 weeks +6 days, trimester 3 (T3, n=100) >28 weeks to term. Results: The normal HbA(1c) reference interval for Caucasian non-pregnant women was 29-37 mmol/mol (Diabetes Control and Complications Trial; DCCT: 4.8%-5.5%), T1: 24-36 mmol/mol (DCCT: 4.3%-5.4%), T2: 25-35 mmol/mol (DCCT: 4.4%-5.4%) and T3: 28-39 mmol/mol (DCCT: 4.7%-5.7%). HbA(1c) was significantly decreased in trimesters 1 and 2 compared to non-pregnant women. Conclusions: HbA(1c) trimester-specific reference intervals are required to better inform the management of pregnancies complicated by diabetes.
Item Type:
Article
Language:
en
ISSN:
1434-6621

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connor, Catherineen_GB
dc.contributor.authorO'Shea, Paula Maryen_GB
dc.contributor.authorOwens, Lisa Annen_GB
dc.contributor.authorCarmody, Louiseen_GB
dc.contributor.authorAvalos, Gloriaen_GB
dc.contributor.authorNestor, Lauraen_GB
dc.contributor.authorLydon, Katherineen_GB
dc.contributor.authorDunne, Fidelmaen_GB
dc.date.accessioned2012-04-24T11:10:33Z-
dc.date.available2012-04-24T11:10:33Z-
dc.date.issued2011-11-26-
dc.identifier.citationTrimester-specific reference intervals for haemoglobin A(1c) (HbA(1c)) in pregnancy. 2011: Clin. Chem. Lab. Med.en_GB
dc.identifier.issn1434-6621-
dc.identifier.pmid22117781-
dc.identifier.doi10.1515/CCLM.2011.397-
dc.identifier.urihttp://hdl.handle.net/10147/220231-
dc.description.abstractAbstract Background: Diabetes in pregnancy imposes additional risks to both mother and infant. These increased risks are considered to be primarily related to glycaemic control which is monitored by means of glycated haemoglobin (HbA(1c)). The correlation of HbA(1c) with clinical outcomes emphasises the need to measure HbA(1c) accurately, precisely and for correct interpretation, comparison to appropriately defined reference intervals. Since July 2010, the HbA(1c) assay in Irish laboratories is fully metrologically traceable to the IFCC standard. The objective was to establish trimester-specific reference intervals in pregnancy for IFCC standardised HbA(1c) in non-diabetic Caucasian women. Methods: The authors recruited 311 non-diabetic Caucasian pregnant (n=246) and non-pregnant women (n=65). A selective screening based on risk factors for gestational diabetes was employed. All subjects had a random plasma glucose <7.7 mmol/L and normal haemoglobin level. Pregnancy trimester was defined as trimester 1 (T1, n=40) up to 12 weeks +6 days, trimester 2 (T2, n=106) 13-27 weeks +6 days, trimester 3 (T3, n=100) >28 weeks to term. Results: The normal HbA(1c) reference interval for Caucasian non-pregnant women was 29-37 mmol/mol (Diabetes Control and Complications Trial; DCCT: 4.8%-5.5%), T1: 24-36 mmol/mol (DCCT: 4.3%-5.4%), T2: 25-35 mmol/mol (DCCT: 4.4%-5.4%) and T3: 28-39 mmol/mol (DCCT: 4.7%-5.7%). HbA(1c) was significantly decreased in trimesters 1 and 2 compared to non-pregnant women. Conclusions: HbA(1c) trimester-specific reference intervals are required to better inform the management of pregnancies complicated by diabetes.-
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to Clinical chemistry and laboratory medicine : CCLM / FESCCen_GB
dc.titleTrimester-specific reference intervals for haemoglobin A(1c) (HbA(1c)) in pregnancy.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.en_GB
dc.identifier.journalClinical chemistry and laboratory medicine : CCLM / FESCCen_GB
dc.description.provinceConnachten

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