Innate immunity in the pathogenesis of psoriasis.

Hdl Handle:
http://hdl.handle.net/10147/218994
Title:
Innate immunity in the pathogenesis of psoriasis.
Authors:
Sweeney, Cheryl M; Tobin, Ann-Marie; Kirby, Brian
Affiliation:
Department of Dermatology, Education and Research Centre, St Vincent's University Hospital, Elm Park, Dublin, Ireland. chsweene@tcd.ie
Citation:
Innate immunity in the pathogenesis of psoriasis. 2011, 303 (10):691-705 Arch. Dermatol. Res.
Journal:
Archives of dermatological research
Issue Date:
Dec-2011
URI:
http://hdl.handle.net/10147/218994
DOI:
10.1007/s00403-011-1169-1
PubMed ID:
21863252
Abstract:
Psoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.
Language:
en
MeSH:
Adaptive Immunity; Animals; Cytokines; Humans; Immunity, Innate; Psoriasis; Signal Transduction; Skin; Th1 Cells; Th17 Cells
ISSN:
1432-069X
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorSweeney, Cheryl M-
dc.contributor.authorTobin, Ann-Marie-
dc.contributor.authorKirby, Brian-
dc.date.accessioned2012-04-18T11:52:36Z-
dc.date.available2012-04-18T11:52:36Z-
dc.date.issued2011-12-
dc.identifier.citationInnate immunity in the pathogenesis of psoriasis. 2011, 303 (10):691-705 Arch. Dermatol. Res.-
dc.identifier.issn1432-069X-
dc.identifier.pmid21863252-
dc.identifier.doi10.1007/s00403-011-1169-1-
dc.identifier.urihttp://hdl.handle.net/10147/218994-
dc.description.abstractPsoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.-
dc.language.isoen-
dc.rightsArchived with thanks to Archives of dermatological researchen_GB
dc.subject.meshAdaptive Immunity-
dc.subject.meshAnimals-
dc.subject.meshCytokines-
dc.subject.meshHumans-
dc.subject.meshImmunity, Innate-
dc.subject.meshPsoriasis-
dc.subject.meshSignal Transduction-
dc.subject.meshSkin-
dc.subject.meshTh1 Cells-
dc.subject.meshTh17 Cells-
dc.titleInnate immunity in the pathogenesis of psoriasis.en_GB
dc.contributor.departmentDepartment of Dermatology, Education and Research Centre, St Vincent's University Hospital, Elm Park, Dublin, Ireland. chsweene@tcd.ie-
dc.identifier.journalArchives of dermatological research-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinsteren

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